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What is Feraheme
FerumoxytolThe Generic name of this drug
Treatment SummaryFerumoxytol is an intravenous drug used to treat iron deficiency anemia in adults with chronic kidney disease. It is made up of tiny particles of iron oxide that are coated in a sugar shell and dissolved in a solution that can be injected quickly.
Feridexis the brand name
Feraheme Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Feridex
Ferumoxytol
2008
3
Approved as Treatment by the FDA
Ferumoxytol, otherwise known as Feridex, is approved by the FDA for 4 uses including Chronic Kidney Disease and Iron Deficiency Anemia (IDA) .Chronic Kidney Disease
Iron Deficiency Anemia (IDA)
Chronic Kidney Disease (CKD)
Iron Deficiency Anemia
Effectiveness
How Feraheme Affects PatientsFerumoxytol is a drug that helps increase the amount of iron in the body, which can help treat anemia. Studies have shown that Ferumoxytol is more effective than oral iron in helping to boost hemoglobin, serum ferritin, and transferrin saturation. It can also be used as a contrast agent for magnetic resonance imaging (MRI) studies. This drug helps increase the time frame to acquire data during MRI studies and it slowly crosses the blood-brain barrier. Iron is an important part of many enzymes and proteins in the body, and its deficiency can lead to anemia and decreased oxygen delivery
How Feraheme works in the bodyFeraheme is a drug made up of an iron core, coated in a carbohydrate shell. This shell allows it to move around the body without interacting with other molecules. When it reaches macrophages in the liver, spleen, and bone marrow, the shell is broken down and the iron is released. The iron can then be stored as ferritin or transported to the red blood cells to make hemoglobin. Iron is also important for many other body processes, such as mitochondrial activity and metabolic functions. Feraheme can replace iron stores without causing many side effects. Additionally, it can be used in MRI scans to dark
When to interrupt dosage
The proposed measure of Feraheme is contingent upon the diagnosed state. The quantity of dosage fluctuates, in line with the method of delivery (e.g. Injection - Intravenous or Solution) featured in the following table.Condition
Dosage
Administration
Chronic Kidney Disease
, 30.0 mg/mL, 0.051 mg/mL, 51.0 mg/mL, 11.2 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous
Iron Deficiency Anemia
, 30.0 mg/mL, 0.051 mg/mL, 51.0 mg/mL, 11.2 mg/mL
, Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous
Warnings
There are 20 known major drug interactions with Feraheme.Common Feraheme Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Ferumoxytol can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Minor
Ferumoxytol can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Phosphate
Minor
Ferumoxytol can cause a decrease in the absorption of Calcium Phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium phosphate dihydrate
Minor
Ferumoxytol can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dipotassium phosphate
Minor
Ferumoxytol can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Feraheme Toxicity & Overdose RiskFeraheme may cause serious allergic reactions, including anaphylaxis and anaphylactoid reactions. Symptoms of a mild allergic reaction, such as itching, rash, hives, or wheezing, have been reported in 3.7% of those who use the drug. No evidence of cancer or fertility problems have been linked to Feraheme. Taking Feraheme can also cause low blood pressure, iron overload, and changes to MRI imaging that may last for up to 12 weeks after the last dose. It is important to monitor patients for signs of allergic reaction and limit administration of the drug only when personnel
Feraheme Novel Uses: Which Conditions Have a Clinical Trial Featuring Feraheme?
118 active clinical trials are presently being conducted to assess the utility of Feraheme in the management of Iron deficiency anemia.Condition
Clinical Trials
Trial Phases
Iron Deficiency Anemia
7 Actively Recruiting
Phase 3, Phase 4, Phase 2
Chronic Kidney Disease
105 Actively Recruiting
Not Applicable, Phase 1, Phase 3, Phase 2, Phase 4, Early Phase 1
Feraheme Reviews: What are patients saying about Feraheme?
5Patient Review
1/10/2015 Feraheme has been an absolute lifesaver for me. I've been getting infusions weekly to monthly for the past seven years and it's kept my iron levels stable. I highly recommend this treatment to anyone who is struggling with iron deficiency.
5Patient Review
4/7/2015 I have severe anemia and my first infusion was with Dextran, where i had no side affects whatsoever, and it took about 1.5 weeks to feel the effects of energy; it lasted about 3.5 months. The second infusion was yesterday with Feraheme. Shorter infusion time, no side effects, hope it works the same. The second dose will be on Monday, but so far so good.
5Patient Review
5/21/2022 I had a great experience with this medication and saw results very quickly. I would highly recommend it to others who are struggling with similar issues.
5Patient Review
4/5/2015 I didn't have any bad reactions. If anything, I felt like I had more energy and generally felt good while taking this medication.
4.3Patient Review
1/5/2015 No adverse affects that I could tell; you go in, get an IV, sit for ten minutes, and then leave. I've been struggling to improve my anemia for years without any success, but this finally seems to be working.
Patient Q&A Section about feraheme
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Feraheme?
"You may experience dizziness, fainting, low blood pressure, injection site reactions, nausea, vomiting, stomach pain, and diarrhea."
Answered by AI
How long does Feraheme infusion last?
"Feraheme will be injected into your vein intravenously (IV) by your healthcare provider. The infusion will last for at least 15 minutes. You will receive two doses of Feraheme, 3 to 8 days apart. Your healthcare provider will monitor you during the infusion and for at least 30 minutes after you receive the medication."
Answered by AI
What is Feraheme infusion?
"Feraheme is a medicine that replaces iron in the body. It works by providing more iron so that the body can make more red blood cells. These blood cells carry oxygen throughout the body. Feraheme is given as an intravenous infusion by a health care professional."
Answered by AI
What happens after Feraheme infusion?
"If you experience any of the following adverse reactions after taking a medication from AMAG Pharmaceuticals, you should report it by calling 1-877-411-2510 or emailing medinfoUS@covispharma.com. The most common adverse reactions are diarrhea, headache, nausea, dizziness, hypotension, constipation, and peripheral edema."
Answered by AI
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