Fanapt

Schizophrenia
Treatment
1 FDA approval
20 Active Studies for Fanapt

What is Fanapt

IloperidoneThe Generic name of this drug
Treatment SummaryIloperidone is a medication used to treat schizophrenia symptoms. It was first researched by Hoechst Marion Roussel Inc. and went through several development phases before being approved by the FDA in 2009. Iloperidone is an atypical antipsychotic and has been marketed and distributed by Novartis since 1998.
Fanaptis the brand name
image of different drug pills on a surface
Fanapt Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fanapt
Iloperidone
2009
37

Approved as Treatment by the FDA

Iloperidone, commonly known as Fanapt, is approved by the FDA for 1 uses including Schizophrenia .
Schizophrenia
Helps manage Schizophrenia

Effectiveness

How Fanapt Affects PatientsIloperidone is used to treat schizophrenia and improve cognition. It works by binding to receptors in the brain, including dopamine D2, α adrenergic, serotonin 5-HT2a and dopamine 3 receptors. It also has moderate affinity for dopamine D4, serotonin 5-HT6 and 5-HT7, and norepinephrine NEα1 receptors, and weak affinity for serotonin 5-HT1A, dopamine D1, and histamine H1 receptors.
How Fanapt works in the bodyIloperidone is a medication that works on two types of brain receptors. It blocks dopamine and serotonin receptors, which helps reduce symptoms of certain mental health conditions.

When to interrupt dosage

The suggested measure of Fanapt is contingent upon the recognized condition. The amount of dosage fluctuates, as per the method of delivery (e.g. Kit or Tablet - Oral) featured in the table beneath.
Condition
Dosage
Administration
Schizophrenia
1.0 mg, 2.0 mg, 4.0 mg, 6.0 mg, 8.0 mg, 10.0 mg, 12.0 mg, , 13.0 mg
, Oral, Tablet, Tablet - Oral, Kit - Oral, Kit

Warnings

There are 20 known major drug interactions with Fanapt.
Common Fanapt Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Iloperidone may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Iloperidone may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Iloperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Iloperidone is combined with Artemether.
Asenapine
Major
Iloperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine.
Fanapt Toxicity & Overdose RiskTaking this drug may cause side effects such as dizziness, dry mouth, tiredness, blocked nose, low blood pressure when standing, drowsiness, fast heart rate, and weight gain (in 5% or more of patients).

Fanapt Novel Uses: Which Conditions Have a Clinical Trial Featuring Fanapt?

170 active trials are currently evaluating the potential of Fanapt to manage Schizophrenia.
Condition
Clinical Trials
Trial Phases
Schizophrenia
97 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2

Fanapt Reviews: What are patients saying about Fanapt?

5Patient Review
4/4/2016
Fanapt for Schizophrenia
Fanapt at a dosage of 6mg has been effective in treating my OCD.
4Patient Review
8/11/2014
Fanapt for Schizophrenia
I'm noticing a definite improvement in my mood, but there's an unfortunate side effect of retrograde ejaculation. I really hope this isn't permanent!
3.7Patient Review
10/20/2012
Fanapt for Schizophrenia
I switched to Fanapt to try and mitigate the issues of TD I was having with Latuda. It did stop that, but introduced some other problems like lightheadedness and sedation which are on-par with Geodon. This is my fifth medication change; at this point, I don't know how many more options I have.
2.7Patient Review
9/17/2013
Fanapt for Schizophrenia
I took 12mg and found it hard to concentrate or feel motivated. My libido also tanked, which was really frustrating.
2.3Patient Review
1/4/2016
Fanapt for Schizophrenia
My blood pressure drops to a dangerously low level with this treatment.
2Patient Review
11/19/2012
Fanapt for Schizophrenia
This medicine made me very tired and I had no desire for sex. Additionally, I started to grow man boobs and gained a lot of weight in a short period of time. The price is also quite high given that it's been on the market for awhile now.
1.7Patient Review
5/1/2012
Fanapt for Additional Medications to Treat Depression
I have been taking Fanapt for a few months now, and I am not seeing any benefits for my depression. In fact, the medication has given me urinary incontinence (an issue not listed in the side effects) which apparently affects 10% of users. Additionally, I've noticed moderate memory loss. This may work well for other people, but it has not helped me at all.
1Patient Review
1/16/2013
Fanapt for Additional Medications to Treat Depression
I experienced a lot of serious side effects while taking this medication, including extreme fatigue, difficulty swallowing, heart palpitations, dizziness, and lightheadedness. Towards the end, I also suddenly developed hypotension which made me faint and unable to walk.
1Patient Review
11/8/2012
Fanapt for Schizophrenia
I've been taking this medication for over a week now and it's not doing anything to help. If anything, the side effects are worse than before.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about fanapt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Fanapt an antipsychotic?

"Fanapt (iloperidone) is an antipsychotic medication that is taken to treat schizophrenia."

Answered by AI

What is the drug Fanapt used for?

"This medication is used to treat certain mental/mood disorders (such as schizophrenia). Iloperidone helps you to think more clearly, feel less nervous, and take part in everyday life. It may also help to decrease hallucinations (hearing/seeing things that are not there)."

Answered by AI

Is Fanapt used for bipolar?

"Iloperidone (Fanapt®) is FDA-approved for the treatment of schizophrenia in adults. It has shown clinical efficacy in four- and six-week trials. Iloperidone is not FDA approved for treatment of bipolar disorder or major depressive disorder."

Answered by AI

How effective is Fanapt?

"Fanapt has an average rating of 6.3 out of 10 from a total of 25 ratings on Drugs.com. More than half of reviewers had a positive experience, while 24% reported a negative experience. Reviews may be edited for grammar/spelling or to remove inappropriate language and content."

Answered by AI

Clinical Trials for Fanapt

Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Image of Vanderbilt Psychiatric Hospital in Nashville, United States.

Repetitive Transcranial Magnetic Stimulation for Schizophrenia

18 - 65
All Sexes
Nashville, TN
The central hypothesis is this: DMN connectivity can be modulated with inhibitory cTBS when delivered on an accelerated treatment schedule. This study seeks to provide evidence that accelerated, network-targeted inhibitory stimulation of the DMN leads to both altered network activity and a concomitant behavioral change in cognitive performance in individuals with schizophrenia and schizoaffective disorder. This study will also compare the effect of inhibitory cTBS in healthy individuals, as it may also lead to both altered network activity and a behavioral change in cognitive performance in individuals without schizophrenia or schizoaffective disorder. If successful, this study will have identified a safe, effective, and broadly applicable treatment for cognitive impairment in schizophrenia that has potential for translation into many other psychiatric and neurodevelopmental disorders, such as autism.
Waitlist Available
Has No Placebo
Vanderbilt Psychiatric HospitalHeather Ward, MD
Image of Woodland International Research Group /ID# 275747 in Little Rock, United States.

Emraclidine for Schizophrenia

18 - 65
All Sexes
Little Rock, AR
Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, perception and sense of self. This study will assess adverse events, change in disease activity, and how oral emraclidine moves through the body in adult participants with schizophrenia Emraclidine is an investigational drug being developed for the treatment of schizophrenia. Participants are placed in one of two parts, Part A or Part B, where each group will receive a different treatment. Participants will receive either oral emraclidine or placebo. Approximately 258 participants will be enrolled across roughly 32 sites in the United States. Participants in Part A will be assigned to one of multiple ascending doses of emraclidine or placebo administered orally for 14 days or up to 21 days. Participants in Part B will receive Emraclidine or placebo administered orally for up to 42 days. Participants will be followed for 30 days after the last dose of the study drug. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Woodland International Research Group /ID# 275747 (+4 Sites)ABBVIE INC.AbbVie
Have you considered Fanapt clinical trials? We made a collection of clinical trials featuring Fanapt, we think they might fit your search criteria.Go to Trials
Have you considered Fanapt clinical trials? We made a collection of clinical trials featuring Fanapt, we think they might fit your search criteria.Go to Trials
Image of Clinical Site in Richmond, United States.

Xanomeline/Trospium for Schizophrenia

18 - 40
All Sexes
Richmond, TX
This is an open label study of the treatment satisfaction, efficacy and tolerability of xanomeline/ trospium in a population of 172 participants diagnosed with schizophrenia in the early phase of illness. Participants will be followed for 24 weeks with scheduled assessments conducted by centralized raters, local mental health professionals and self-assessments completed by patients. Recruitment will be based on insufficient efficacy of previous antipsychotic or due to dissatisfaction with treatment as a result of unacceptable side effects on previous antipsychotic/patient choice, with approximately 50% for each enrollment criteria. Participants who present with both insufficient efficacy and unacceptable side effects will be considered as belonging to the insufficient efficacy subgroup. Treatment and assessments will be identical for the 2 groups. Primary outcome for participants enrolled will be improvement in overall treatment satisfaction as measured by the MSQ.
Phase 4
Waitlist Available
Clinical SiteBristol-Myers Squibb
Have you considered Fanapt clinical trials? We made a collection of clinical trials featuring Fanapt, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security