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What is Exjade
DeferasiroxThe Generic name of this drug
Treatment SummaryDeferasirox is a medication that binds to iron in the body and helps remove it. It is the first oral medication approved by the FDA for chronic iron overload in patients who have received blood transfusions over a long period of time.
Exjadeis the brand name
Exjade Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Exjade
Deferasirox
2005
112
Effectiveness
How Exjade Affects PatientsDeferasirox is a medication taken by mouth to remove iron from the body. It binds to iron molecules and helps the body get rid of them. It does not have much of an effect on zinc and copper, but it can lower their levels in the blood. It is unknown if this lowering of zinc and copper levels has any real significance.
How Exjade works in the bodyDeferasirox works by binding to iron molecules in the body, forming a stable complex. This complex is then eliminated from the body through urine. Deferasirox has a strong affinity for trivalent iron, so it can bind to one iron atom with two molecules of deferasirox.
When to interrupt dosage
The measure of Exjade relies upon the recognized condition, including Iron Overload, Blood Transfusions and Non-transfusion Dependent Thalassemia. The quantity of dosage varies according to the method of delivery (e.g. Granule or Tablet, film coated) outlined in the table beneath.Condition
Dosage
Administration
Blood Transfusions
125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg
, Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated - Oral, Tablet, coated
Non-transfusion Dependent Thalassemia
125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg
, Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated - Oral, Tablet, coated
Iron Overload
125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg
, Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated - Oral, Tablet, coated
Warnings
Exjade has four contraindications and therefore should not be taken if you are enduring any of the conditions in the following table.Exjade ContraindicationsCondition
Risk Level
Notes
Advanced Malignancies
Do Not Combine
High-risk Myelodysplastic Syndrome (MDS)
Do Not Combine
Poor Performance Status
Do Not Combine
Pulse Frequency
Do Not Combine
Common Exjade Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Deferasirox.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Deferasirox.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Deferasirox.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Deferasirox.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Deferasirox.
Exjade Novel Uses: Which Conditions Have a Clinical Trial Featuring Exjade?
Currently, there are zero active studies investigating the potential of Exjade to ameliorate Blood Transfusions, Non-transfusion Dependent Thalassemia and Iron Overload.Condition
Clinical Trials
Trial Phases
Blood Transfusions
0 Actively Recruiting
Iron Overload
0 Actively Recruiting
Non-transfusion Dependent Thalassemia
0 Actively Recruiting
Exjade Reviews: What are patients saying about Exjade?
5Patient Review
10/5/20074.7Patient Review
10/26/2007 Worked very well to bring my ferritin levels down. Easy to use, just have to remember to take it with you and use on an empty stomach. I used it before dinner, so had to make sure to take before going out to dinner or for day long outings. The only downside is the high cost.
4.7Patient Review
5/2/2013 This medication really helped with my constipation.
4.3Patient Review
12/17/2010 I developed a severe rash after a few weeks, so I had to restart the treatment on a low dose with steroids. In addition, I take flaxseed oil and eat a higher dairy diet. My skin gets very dry, so moisturizing often is key.
4.3Patient Review
1/22/2014 I developed a rash and itchiness after using this treatment.
4Patient Review
6/28/2009 I have Sidroblastic anemia, which means I have too much iron in my blood. Defeoxamine worked well for me, but it was tough on my body. Injection site, etc. Exjade is a good alternative and doesn't require injections, which is great. However, it upsets my stomach pretty badly. I am currently taking it right before bed.
3.7Patient Review
2/27/2012 I've been taking this medication for six years as a result of my transfusion-dependent anemia. Zantac has helped me immensely with the stomach problems I experience as a side effect. Additionally, I find that it works better if I take it at night rather than in the morning.
3.3Patient Review
6/8/2010 After using this medication for an extended period of time, I found it to be very harsh on my stomach.
3Patient Review
2/22/2018 I'm hopeful that this will work long-term, but I don't like having to mix it with juice. It's a bit of an unpleasant experience, especially since the flavor of the juice doesn't seem to change. After the first dose, I was in the bathroom for two hours. Here's hoping that my stomach can adjust.
3Patient Review
12/20/2013 I have too much iron in my blood according to this treatment. I'm a MDS patient.
3Patient Review
5/2/2009 While this treatment may work for some, I unfortunately have not seen much of a change in my condition.
2.7Patient Review
10/31/2016 I've only been taking exjade for a month now, and it's tough on my stomach and heart.
2.3Patient Review
2/14/2008 I'm currently using Defeoxamine, which involves a lot of equipment and can be quite cumbersome. I was hoping Exjade would be a simpler solution.
2Patient Review
6/28/2014 I have MDS and severe stomach/intestinal problems that made this medication intolerable for me due to the extreme diarrhea it caused.
1Patient Review
3/18/2010 I've had to get a lot of blood transfusions for leukemia, and as a result I now have iron overload with a ferritin level of 2300. I've been taking Exjade for almost a year, but my ferritin levels keep fluctuating. They got as low as 981 but then went up again. Not only is the medication EXPENSIVE, it also gives me stomach problems. I don't know where to go from here. Are there foods that can help? I've limited my meat consumption but then I'm anemic. Help!!
Patient Q&A Section about exjade
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for Exjade to work?
"Deferasirox is a bivalent iron chelator that is taken orally as a tablet, once a day. It is readily absorbed and reaches peak concentration in blood after 1 to 2 hours. The half-life is 12 to 17 hours, and effective levels of active chelator are maintained in the blood for more than 24 hours."
Answered by AI
When should I take Exjade?
"You should take EXJADE once a day at around the same time. You can take it with or without food, but it might be easier on your stomach if you take it with a light meal. Taking it at the same time each day will help you remember to take your tablets."
Answered by AI
What is the difference between Exjade and Jadenu?
"There are two forms of the medication - Exjade and Jadenu. Exjade must be mixed in liquid and taken on an empty stomach, whereas Jadenu can be taken without food. Jadenu is therefore simpler to administer for those with chronic iron overload."
Answered by AI
What is Exjade used for?
"This medication is used to treat high levels of iron in the body. It is used to treat high levels of iron in people with a certain blood disorder who do not require blood transfusions."
Answered by AI