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What is Everolimus
EverolimusThe Generic name of this drug
Treatment SummaryEverolimus is a drug that works like Rapamycin, an immunosuppressant used to help prevent organ transplant rejection. It stops the mTORC1 protein from working, but does not affect the mTORC2 protein.
Afinitoris the brand name
Everolimus Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Afinitor
Everolimus
2009
59
Approved as Treatment by the FDA
Everolimus, also known as Afinitor, is approved by the FDA for 12 uses including Tuberous Sclerosis and unresectable gastrointestinal origin Progressive Neuroendocrine Tumors .Tuberous Sclerosis
unresectable gastrointestinal origin Progressive Neuroendocrine Tumors
Lung
Advance Directives
Used to treat refractory, advanced Breast cancer in combination with Exemestane
refractory Advanced Renal Cell Carcinoma
Neoplasm Metastasis
Steroid therapy
Used to treat Steroid therapy in combination with Tacrolimus
Neuroendocrine Tumors
Tuberous Sclerosis
locally advanced lung origin Progressive Neuroendocrine Tumors
pancreatic origin Progressive Neuroendocrine Tumors
metastatic lung origin Progressive Neuroendocrine Tumors
Effectiveness
How Everolimus works in the bodyEverolimus is a drug that targets the mTOR protein, which helps control cell growth and division. By blocking the mTOR protein, Everolimus stops cells from dividing and growing, which can stop cancer cells from spreading. It also prevents new blood vessels from forming, which starves the cancer cells of oxygen and nutrients. Finally, it reduces the amount of glucose (sugar) that cancer cells can take in, further starving them of energy.
When to interrupt dosage
The proposed measure of Everolimus is contingent upon the marked condition, including metastatic lung origin Progressive Neuroendocrine Tumors, Heart and Advance Directives. The quantity likewise fluctuates as per the approach of delivery (e.g. Tablet or Oral) featured in the table beneath.Condition
Dosage
Administration
pancreatic origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Advance Directives
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Waldenstrom Macroglobulinemia
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
metastatic lung origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Tuberous Sclerosis
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Tuberous Sclerosis
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
unresectable gastrointestinal origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
refractory Advanced Renal Cell Carcinoma
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Steroid therapy
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
advanced Carcinoid tumor
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Lung
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Neoplasm Metastasis
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
locally advanced lung origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Everolimus.Common Everolimus Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Everolimus.
Abetimus
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with Acteoside.
Everolimus Toxicity & Overdose RiskThe drug is toxic at 0.63 nanomolar concentrations.
Everolimus Novel Uses: Which Conditions Have a Clinical Trial Featuring Everolimus?
16 active clinical trials are currently in progress to assess the potential of Everolimus in providing advanced treatment of locally advanced lung origin Progressive Neuroendocrine Tumors, advanced Carcinoid tumor and Heart ailments.Condition
Clinical Trials
Trial Phases
Steroid therapy
0 Actively Recruiting
Waldenstrom Macroglobulinemia
0 Actively Recruiting
advanced Carcinoid tumor
0 Actively Recruiting
metastatic lung origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Tuberous Sclerosis
0 Actively Recruiting
pancreatic origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Tuberous Sclerosis
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
unresectable gastrointestinal origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Neoplasm Metastasis
0 Actively Recruiting
Neuroendocrine Tumors
0 Actively Recruiting
refractory Advanced Renal Cell Carcinoma
0 Actively Recruiting
Lung
0 Actively Recruiting
locally advanced lung origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Everolimus Reviews: What are patients saying about Everolimus?
4Patient Review
12/22/2014 I was using this as an anti-rejection medication for my liver transplant, and it also worked well as a chemo drug against a tumor that developed in my old liver. The only issues I had were a canker sore (which was easily treated), some swelling in one lower leg (treated with lymphodema massage), and a few skin bumps/boils. I continued to use Prograf in addition to Zortress.
2Patient Review
1/27/2012 On the ninth day after starting this treatment, I developed severe mouth sores.
Patient Q&A Section about everolimus
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is everolimus a chemotherapy?
"Everolimus works by inhibiting the growth of cancer cells.
Everolimus is a chemotherapy drug that stops cancer cells from growing. It is a type of drug called an "mTOR kinase inhibitor.""
Answered by AI
How long can you take everolimus?
"You should take everolimus every day for as long as it keeps working or until you experience unacceptable side effects. It is a long-term treatment. In clinical trials, people took the average for 24.0 weeks (range one week to almost 200 weeks)."
Answered by AI
What is the drug everolimus used for?
"Everolimus is a medication that is used to treat late-stage cancers, noncancerous tumors, such as kidney and breast cancer, subependymal giant cell astrocytoma (SEGA, a brain tumor), renal angiomyolipoma (kidney tumor), partial-onset seizures (epilepsy) with tuberous sclerosis complex (TSC), and neuroendocrine tumors."
Answered by AI
What are the side effects of everolimus?
"The following are symptoms of something wrong: bloating or swelling of the face, arms, hands, lower legs, or feet; bloody nose; chest pain or tightness; decreased weight; difficult or labored breathing; difficulty with swallowing; sores, ulcers, or white spots on the lips, tongue, or inside the mouth; tingling of the hands or feet."
Answered by AI