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What is Emtricitabine And Tenofovir Disoproxil Fumarate
EmtricitabineThe Generic name of this drug
Treatment SummaryTenofovir disoproxil fumarate, sold under the brand name Viread, is a medication used to treat HIV and hepatitis B infections. It belongs to a class of drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs) and must usually be taken in conjunction with other antiretroviral drugs. Tenofovir disoproxil was first approved by the FDA in 2001.
Emtrivais the brand name
Emtricitabine And Tenofovir Disoproxil Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Emtriva
Emtricitabine
2003
131
Approved as Treatment by the FDA
Emtricitabine, also called Emtriva, is approved by the FDA for 2 uses including HIV and adults and pediatric patients weighing at least 17 kg .HIV
Helps manage Human Immunodeficiency Virus Type 1 (HIV-1) Infection
adults and pediatric patients weighing at least 17 kg
Effectiveness
How Emtricitabine And Tenofovir Disoproxil Fumarate Affects PatientsTenofovir is a drug used to treat HIV-1 and Hepatitis B infections. In lab studies, it has been found to be effective against HIV-1 virus, with an EC50 (50% effective concentration) between 0.04 μM to 8.5 μM. When taken in combination with other drugs (nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors), it has been seen to have additive and synergistic effects against HIV-1.
How Emtricitabine And Tenofovir Disoproxil Fumarate works in the bodyTenofovir is a medicine used to treat HIV. It belongs to a group of drugs called nucleotide analog reverse transcriptase inhibitors, which work by blocking a virus-making enzyme in the body. Tenofovir is changed by the body into an active form which stops the virus from making more copies of itself. In rare cases, the virus can become resistant to this medication. This happens when a virus mutation changes how it interacts with the drug.
When to interrupt dosage
The advised dosage of Emtricitabine And Tenofovir Disoproxil Fumarate is contingent upon the perceived condition, including Anti-Retroviral Agents, High Risk Patients and Chronic Hepatitis B. The measure of dosage shifts, in light of the delivery approach (e.g. Tablet or Tablet, film coated) noted in the table underneath.Condition
Dosage
Administration
HIV Transmission
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV test negative
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Anti-Retroviral Agents
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight more than 35 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight at least 14 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV Infections
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight at least 35 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Antiretroviral Therapy
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
treatment failure
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
adults and pediatric patients weighing at least 17 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Sexual Behaviour
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
not requiring CYP3A inhibitors
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Warnings
Emtricitabine And Tenofovir Disoproxil Fumarate ContraindicationsCondition
Risk Level
Notes
HIV
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Emtricitabine may interact with Pulse Frequency
Common Emtricitabine And Tenofovir Disoproxil Fumarate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Emtricitabine.
Procainamide
Major
The excretion of Procainamide can be decreased when combined with Emtricitabine.
Topotecan
Major
The excretion of Topotecan can be decreased when combined with Emtricitabine.
Cefradine
Minor
The excretion of Cefradine can be decreased when combined with Emtricitabine.
Estrone sulfate
Minor
The excretion of Estrone sulfate can be decreased when combined with Emtricitabine.
Emtricitabine And Tenofovir Disoproxil Fumarate Toxicity & Overdose RiskIt is not recommended for breastfeeding mothers to take tenofovir disoproxil due to the risk of postnatal transmission of HIV-1. Tenofovir disoproxil has been tested for carcinogenic effects in mice and rats and showed an increased risk of liver adenomas in female mice at higher doses. Pregnancy is categorized as a B drug, and animal studies have revealed no evidence of harm to the fetus, although human studies are limited. There is evidence that tenofovir disoproxil is mutagenic in mouse lymphoma assays and an in vivo mouse micronucleus
Emtricitabine And Tenofovir Disoproxil Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Emtricitabine And Tenofovir Disoproxil Fumarate?
46 active trials are being conducted to assess the potential of a combination of Emtricitabine and Tenofovir Disoproxil Fumarate to replace the existing antiretroviral therapies for virologically suppressed (HIV1 RNA <50 copies/mL) adult patients, Chronic Hepatitis B and HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
HIV Transmission
0 Actively Recruiting
HIV
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
HIV Infections
0 Actively Recruiting
HIV test negative
0 Actively Recruiting
adults and pediatric patients weighing at least 17 kg
0 Actively Recruiting
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
not requiring CYP3A inhibitors
0 Actively Recruiting
weight more than 35 kg
0 Actively Recruiting
weight at least 35 kg
0 Actively Recruiting
weight at least 14 kg
0 Actively Recruiting
Sexual Behaviour
17 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Emtricitabine And Tenofovir Disoproxil Fumarate Reviews: What are patients saying about Emtricitabine And Tenofovir Disoproxil Fumarate?
5Patient Review
10/24/2010 I was already using 3TC and another drug, Tenofovir, so adding Truvada or Emitricitabine/tenofovir 200mg/300 mg had no trouble taking it. I use it in combination with Raltegravir Potassium 400 mg/Isentress 400 mg. However, I started having severe itching all over my body that the antihistamines didn't help relieve. My allergist isn't sure what to do other than stop the HIV drug, but there's nothing to replace it with without causing a reaction.
Patient Q&A Section about emtricitabine and tenofovir disoproxil fumarate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug emtricitabine used for?
"Emtricitabine is used with other medications to treat human immunodeficiency virus (HIV) infection. Emtricitabine belongs to a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood."
Answered by AI
What is emtricitabine and tenofovir disoproxil fumarate used for?
"This medication is used to treat HIV in adults and children who weigh at least 37 pounds. It is a combination of emtricitabine and tenofovir."
Answered by AI
Is emtricitabine tenofovir used for PrEP?
"Prep drugs can help prevent HIV infection in people who are at risk of becoming infected and don't have HIV. PrEP involves taking a combination drug of emtricitabine-tenofovir (Truvada) or emtricitabine plus tenofovir alafenamide (Descovy) every day."
Answered by AI
What are the side effects of tenofovir and emtricitabine?
"The possible side effects of the medication include nausea, vomiting, stomach pain, diarrhea, headache, dizziness, depression, and joint pain."
Answered by AI