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What is Dyrenium
TriamtereneThe Generic name of this drug
Treatment SummaryTriamterene is a medication used to treat high blood pressure. It helps the body excrete more sodium and water while preventing the loss of potassium in the kidneys. This drug can cause an increase in potassium levels, which can be dangerous, and it can also make the skin more sensitive to sunlight. Triamterene was first approved by the FDA in 1964. It is used on its own or combined with hydrochlorothiazide to treat edema or hypertension.
Maxzideis the brand name
Dyrenium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxzide
Triamterene
1988
188
Effectiveness
How Dyrenium Affects PatientsTriamterene is a medication used to lower blood pressure and reduce swelling caused by fluid build-up. It works mainly in the kidneys, blocking the reabsorption of sodium and reducing the excretion of potassium. Too much potassium in the body can cause heart problems, so it is important to monitor your potassium levels when taking triamterene. It may also increase the effectiveness of hydrochlorothiazide, another drug used to lower blood pressure. Triamterene does not impact calcium levels in the body.
How Dyrenium works in the bodyTriamterene blocks the channels in your kidneys that normally let sodium and other ions through. By doing this, it increases the amount of sodium leaving your body and brings down the amount of potassium and other ions lost during urination. Triamterene is similar to another drug called amiloride, but it also increases the amount of magnesium you excrete in your urine.
When to interrupt dosage
The measure of Dyrenium is reliant upon the diagnosed ailment, including Cirrhosis, Hypokalemia and Edema. The amount of dosage is contingent upon the technique of delivery (e.g. Capsule or Tablet - Oral) outlined in the table beneath.Condition
Dosage
Administration
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diuretics
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypokalemia
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Cirrhosis
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Swollen feet or ankles
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Nephrotic Syndrome
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Thiazides
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Congestive Heart Failure
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Warnings
Dyrenium ContraindicationsCondition
Risk Level
Notes
severe progressive kidney disease
Do Not Combine
elevated serum potassium levels
Do Not Combine
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Liver diseases
Do Not Combine
Common Dyrenium Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Neomycin.
Tacrolimus
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tacrolimus.
Tenofovir
Major
Triamterene may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Triamterene may increase the nephrotoxic activities of Tenofovir alafenamide.
Dyrenium Toxicity & Overdose RiskTaking too much triamterene can lead to nausea, vomiting, stomach cramps, weakness, and low blood pressure. This is because of electrolyte imbalances like high potassium levels. To treat an overdose, vomiting and stomach lavage should be done and the electrolyte and fluid balance should be monitored. Dialysis may also help remove the drug from the body. In mice, triamterene was linked to liver tumors, but this was not found to be dose-dependent. No mutagenic or chromosomal changes have been seen in studies. It is not recommended to take triamterene during pregnancy
Dyrenium Novel Uses: Which Conditions Have a Clinical Trial Featuring Dyrenium?
138 active studies are underway to assess the potential of Dyrenium in providing relief for Cirrhosis, Hypokalemia and Nephrotic Syndrome.Condition
Clinical Trials
Trial Phases
Nephrotic Syndrome
11 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Diuretics
0 Actively Recruiting
Edema
0 Actively Recruiting
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Thiazides
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypokalemia
0 Actively Recruiting
Dyrenium Reviews: What are patients saying about Dyrenium?
4Patient Review
7/1/2009 I've developed leg cramps, indigestion, and a raw stomach since using this medicine one week ago.
3.7Patient Review
2/13/2009 These cramps were really awful. I couldn't stand or walk without excruciating pain in my legs.
3Patient Review
2/3/2010 After taking just one pill of this medication, I started having cramps in my legs, calves, feet, and hands.
2Patient Review
6/22/2008 The side effects of this medication were so bad that I had to go to the ER, and no one even realized it was from the meds!
2Patient Review
5/2/2009 I experienced some side effects while taking this medication, such as dizziness and a rapid heart rate. However, it did successfully reduce fluid retention for me. I stopped taking it due to the intensity of the side effects.
Patient Q&A Section about dyrenium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking triamterene?
"Abdominal or stomach pain, feeling very agitated, black or tarry-looking stool, blood in the urine or stool, clay-colored stool, cloudy urine, seizures, less urine than usual."
Answered by AI
Does Dyrenium lower potassium?
"The medication Triamterene (Dyrenium) can increase the levels of potassium in your body."
Answered by AI
What is the purpose of triamterene?
"Triamterene is a diuretic that helps to treat edema by reducing the amount of fluid retained in the body. It is typically used in conjunction with other medications to treat conditions such as heart and liver disease."
Answered by AI
What is Dyrenium used for?
"This medication is used to decrease swelling that is caused by conditions such as cancer, congestive heart failure, liver disease, and kidney disease. This effect can help your kidneys work better and lessen symptoms such as trouble breathing and swelling in your ankles, feet, hands, or belly."
Answered by AI