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What is Drixoral
OxymetazolineThe Generic name of this drug
Treatment SummaryOxymetazoline is a medication used to treat facial redness, nasal and sinus congestion, and ptosis (drooping eyelids). It is available in various forms, such as over-the-counter nasal sprays, intranasal sprays for regional anesthesia during dental procedures, and ophthalmic sprays approved in July 2020 to treat ptosis. Oxymetazoline is a direct-acting alpha-adrenergic agonist, meaning it stimulates the alpha-adrenergic receptors in the body.
Afrin Original Pump Mistis the brand name
Drixoral Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Afrin Original Pump Mist
Oxymetazoline
1975
7
Approved as Treatment by the FDA
Oxymetazoline, commonly known as Afrin Original Pump Mist, is approved by the FDA for 3 uses including Anesthesia, Conduction and weight 40 kg or more .Anesthesia, Conduction
Used to treat induction of Regional Anesthesia in combination with Tetracaine
weight 40 kg or more
Used to treat weight 40 kg or more in combination with Tetracaine
Anesthesia, Conduction
Used to treat Regional Anesthesia therapy in combination with Tetracaine
Effectiveness
How Drixoral Affects PatientsOxymetazoline is a medication that helps to narrow the blood vessels and reduce blood flow. It can also reduce nasal congestion and improve breathing in patients with a cold. In addition, studies have shown that oxymetazoline has antioxidant properties, meaning it can protect cells from damage caused by inflammation.
How Drixoral works in the bodyOxymetazoline is used to treat a variety of conditions, including rosacea, blepharoptosis, and nasal congestion. It works by binding to special receptors in the body that cause blood vessels to constrict, which reduces blood flow and swelling. This can help reduce the redness of rosacea, elevate the eyelid in blepharoptosis, and reduce nasal congestion. It is also used in combination with other medications for local anesthetic in dentistry to counteract the vasodilatory effects.
When to interrupt dosage
The measure of Drixoral is contingent upon the diagnosed affliction, including Regional Anesthesia, weight 40 kg or more and Hay Fever. The amount of dosage can be found in the table below, depending on the technique of application (e.g. Solution - Nasal or Solution).Condition
Dosage
Administration
Sinus Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Acquired Blepharoptosis
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
persistent facial erythema
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Nasal Intubation
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Rhinorrhea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Rosacea
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Postoperative Hemorrhages
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Nasal Congestion
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Anesthesia, Conduction
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
weight 40 kg or more
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
acute Rhinitis
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Airway visualization
, 0.5 mg/mL, 50.0 mg/mL, 0.75 mg/mL, 0.0005 mg/mL, 0.512 mg/mL, 0.5095 mg/mL, 0.5055 mg/mL, 0.000005 mL/mL, 2.0 mg/mL, 0.05 mg/mL, 0.05 %, 0.025 %, 0.05 mg, 0.5 %, 0.25 mg/mL, 0.0005 mg/mg, 0.01 mg/mg, 500.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 1.5 mg/mL
, Nasal, Spray, Spray - Nasal, Spray, metered, Spray, metered - Nasal, Liquid, Liquid - Nasal, Oral, Spray - Oral, Topical, Liquid - Topical, Solution - Nasal, Solution, Solution / drops; Spray, Solution / drops; Spray - Nasal, Ophthalmic, Liquid - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Cream, Cream - Topical, Solution - Ophthalmic, Spray - Topical, Solution / drops - Nasal, Kit, Nasal; Oral, Kit - Topical, Jelly, Jelly - Nasal
Warnings
Drixoral has one contraindication and should not be consumed when experiencing the conditions detailed in the following table.Drixoral ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Oxymetazoline may interact with Pulse Frequency
Common Drixoral Drug Interactions
Drug Name
Risk Level
Description
Antazoline
Major
The absorption of Antazoline can be decreased when combined with Oxymetazoline.
Azelastine
Major
The absorption of Azelastine can be decreased when combined with Oxymetazoline.
Beclomethasone dipropionate
Major
The absorption of Beclomethasone dipropionate can be decreased when combined with Oxymetazoline.
Betamethasone
Major
The absorption of Betamethasone can be decreased when combined with Oxymetazoline.
Budesonide
Major
The absorption of Budesonide can be decreased when combined with Oxymetazoline.
Drixoral Toxicity & Overdose RiskThe toxic dose of oxymetazoline in rats is 680 micrograms per kilogram when taken orally and 1630 micrograms per kilogram when taken subcutaneously. In mice, the toxic dose is 4700 micrograms per kilogram when taken orally, 48 milligrams per kilogram when taken intraperitoneally, and 34 milligrams per kilogram when taken subcutaneously. Accidental overdose in both children and adults has caused dizziness, chest pain, headaches, heart attack, stroke, vision problems, irregular heartbeat, high or low blood pressure, sleepiness, and even coma. Rebound congestion
Drixoral Novel Uses: Which Conditions Have a Clinical Trial Featuring Drixoral?
Thirteen active studies are examining the potential of Drixoral to provide Nasal Congestion relief, Ear Conduction Anesthesia and other benefits.Condition
Clinical Trials
Trial Phases
Rhinorrhea
0 Actively Recruiting
persistent facial erythema
0 Actively Recruiting
Rosacea
0 Actively Recruiting
Nasal Intubation
0 Actively Recruiting
weight 40 kg or more
0 Actively Recruiting
Nasal Congestion
1 Actively Recruiting
Not Applicable
Anesthesia, Conduction
0 Actively Recruiting
Sinus Congestion
0 Actively Recruiting
Anesthesia, Conduction
0 Actively Recruiting
acute Rhinitis
0 Actively Recruiting
Airway visualization
0 Actively Recruiting
Postoperative Hemorrhages
3 Actively Recruiting
Not Applicable, Phase 1
Acquired Blepharoptosis
0 Actively Recruiting
Drixoral Reviews: What are patients saying about Drixoral?
5Patient Review
10/12/2009 This medication has been a life-saver for me. It quickly and effectively clears up my symptoms, which is more than I can say for other medications I've tried. Unfortunately, it seems like Walmart no longer carries it and that it's no longer being made. Are there any other places where I can get this medication?
5Patient Review
9/24/2010 I've used this for over 15 years, and I need it now! It's really effective, but I can't seem to find it anywhere. Why has it been discontinued?
5Patient Review
8/12/2012 This is the only thing that has worked on my non-allergic rhinitis. I bought it from a Canadian pharmacy a few years ago, but they don't carry it anymore.
5Patient Review
9/2/20085Patient Review
3/25/2011 We need to know if this drug is available under another name.
5Patient Review
10/3/2011 This decongestant is amazing! It quickly dried up my sinuses and the effects lasted for at least 12 hours, if not more.
3.3Patient Review
11/15/2011 I'm glad this medication is available in Canada now. It's been effective for me with no negative consequences that I've noticed.
Patient Q&A Section about drixoral
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was Drixoral taken off the market?
"At present, Drixoral is not available on the US market due to manufacturing changes by the company Merck. According to Merck's updated website, they do not expect the product to be available in 2010."
Answered by AI
What is Drixoral used for?
"Decongestants help to reduce swelling in the nose.
This medication is used to temporarily relieve symptoms caused by the common cold, flu, allergies, or other breathing illnesses. Antihistamines help relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Decongestants help reduce swelling in the nose."
Answered by AI
What are the side effects of Drixoral?
"Some common side effects of Adderall include blurred vision, dizziness, lightheadedness, drowsiness, high blood pressure, nervousness, and palpitations."
Answered by AI
Can you still get Drixoral?
"Drixoral is unavailable at the moment but it hasn't been permanently taken off the market, according to Schering-Plough. "We are currently in the process of changing manufacturing locations," says Julie Lux, a company spokesperson."
Answered by AI