Dilt-Cd
Angina Pectoris, Variant, Atrial Fibrillation, Proteinuria + 11 more
Treatment
6 FDA approvals
20 Active Studies for Dilt-Cd
Treatment for
Angina Pectoris, Variant
What is Dilt-Cd
Diltiazem
The Generic name of this drug
Treatment Summary
Diltiazem is a medication used to treat high blood pressure, abnormal heart rhythms, and chest pain. It works by blocking the influx of calcium into the cells of the heart and blood vessels, causing them to relax and widen. Diltiazem is available in both oral and intravenous forms and is commonly sold under the brand names Cardizem and Tiazac. It has also been used off-label to treat anal fissures, migraine prevention, pulmonary hypertension, and night-time leg cramps.
Cardizem
is the brand name
Dilt-Cd Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardizem
Diltiazem
1982
656
Approved as Treatment by the FDA
Diltiazem, commonly known as Cardizem, is approved by the FDA for 6 uses which include Coronary Vasospasm and Coronary Artery Vasospasm .
Coronary Vasospasm
Helps manage Coronary Artery Vasospasm
Coronary Artery Vasospasm
Helps manage Coronary Artery Vasospasm
Anginal Pain
Helps manage Anginal Pain
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Angina Pectoris
Helps manage Anginal Pain
Effectiveness
How Dilt-Cd Affects Patients
Diltiazem is a drug used to treat high blood pressure. It works by relaxing the walls of the blood vessels, which lowers the pressure in the vessels, reducing the risk of strokes and heart attacks. It also reduces heart rate. The amount of blood pressure reduction depends on how high the blood pressure is. Studies on people with essential hypertension have shown that taking diltiazem can reduce diastolic blood pressure by a range of 1.9-8.6 mmHg, depending on the dose taken. People with chronic stable angina have been found to have increased exercise tolerance when taking diltiazem. In a
How Dilt-Cd works in the body
Diltiazem works by blocking calcium channels in the heart and blood vessels, which reduces the amount of calcium entering the cells. This lowers the amount of calcium in the cells, allowing them to relax and reducing tension in the muscle. This leads to dilation of the coronary and systemic arteries, increased oxygen delivery to the heart muscle, decreased total peripheral resistance, decreased blood pressure, and decreased afterload. Diltiazem also decreases heart rate and contractility, making it an effective treatment for chronic stable angina.
When to interrupt dosage
The advocated amount of Dilt-Cd is contingent upon the diagnosed state, including prophylaxis of migraine headaches, Fissure;Anal and Anginal Pain. The dosage is subject to the administration route specified in the table below.
Condition
Dosage
Administration
Atrial Fibrillation
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Angina Pectoris
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Coronary Vasospasm
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Angina Pectoris, Variant
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Proteinuria
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Hypertensive disease
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Angina, Stable
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Tachycardia, Supraventricular
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Cardiomyopathy, Dilated
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Migraine Disorders
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Diabetic Neuropathy
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Pulmonary Hypertension
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Fissure in Ano
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Muscle Cramp
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution - Intravenous, Injection - Intravenous
Warnings
Dilt-Cd Contraindications
Condition
Risk Level
Notes
Heart Attack
Do Not Combine
accessory bypass tract
Do Not Combine
accessory bypass tract
Do Not Combine
Bradycardia
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulmonary Congestion
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Hypotension
Do Not Combine
There are 20 known major drug interactions with Dilt-Cd.
Common Dilt-Cd Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Diltiazem.
Alfentanil
Major
The metabolism of Alfentanil can be decreased when combined with Diltiazem.
Amifostine
Major
Diltiazem may increase the hypotensive activities of Amifostine.
Dilt-Cd Toxicity & Overdose Risk
Diltiazem has an oral LD50 ranging from 415 to 740mg/kg in mice and 560 to 810 mg/kg in rats. In dogs, the oral LD50 is estimated to be over 50 mg/kg, and in monkeys it is 360 mg/kg. Reports of overdoses from doses as low as 1g up to 18g have been reported and can cause symptoms such as slow heartbeat, low blood pressure, heart block, or heart failure. Treating an overdose with diltiazem can involve supportive measures, gastric lavage, activated charcoal, and intravenous calcium. Long-term use in animals
Dilt-Cd Novel Uses: Which Conditions Have a Clinical Trial Featuring Dilt-Cd?
228 active trials are currently in progress to assess the potential of Dilt-Cd in alleviating Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
95 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Diabetic Neuropathy
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Pulmonary Hypertension
31 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Tachycardia, Supraventricular
2 Actively Recruiting
Phase 3, Phase 2
Angina, Stable
0 Actively Recruiting
Angina Pectoris, Variant
0 Actively Recruiting
Angina Pectoris
2 Actively Recruiting
Not Applicable, Phase 4
Cardiomyopathy, Dilated
1 Actively Recruiting
Not Applicable
Proteinuria
5 Actively Recruiting
Phase 2, Phase 3, Phase 4, Phase 1
Muscle Cramp
0 Actively Recruiting
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Vasospasm
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Fissure in Ano
0 Actively Recruiting
Dilt-Cd Reviews: What are patients saying about Dilt-Cd?
4.7
Patient Review
6/20/2008
Dilt-Cd for High Blood Pressure
4.3
Patient Review
6/15/2009
Dilt-Cd for Ventricular Rate Control in Atrial Fibrillation
4
Patient Review
5/28/2009
Dilt-Cd for High Blood Pressure
4
Patient Review
7/31/2009
Dilt-Cd for Ventricular Rate Control in Atrial Fibrillation
4
Patient Review
11/29/2009
Dilt-Cd for Hypertrophic Cardiomyopathy
3.7
Patient Review
9/22/2009
Dilt-Cd for Ventricular Rate Control in Atrial Fibrillation
3
Patient Review
3/15/2010
Dilt-Cd for Osteoporosis
2.3
Patient Review
6/5/2009
Dilt-Cd for High Blood Pressure
2
Patient Review
5/15/2009
Dilt-Cd for High Blood Pressure
2
Patient Review
7/7/2009
Dilt-Cd for High Blood Pressure
1.3
Patient Review
11/8/2007
Dilt-Cd for Ventricular Rate Control in Atrial Fibrillation
Patient Q&A Section about dilt-cd
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is diltiazem CD used for?
"Diltiazem is used to treat high blood pressure and chest pain by relaxing blood vessels and increasing blood and oxygen supply to the heart."
Answered by AI
Is diltiazem ER the same as diltiazem CD?
"Diltiazem is a medication used to treat high blood pressure and prevent chest pain. It works by relaxing blood vessels, which decreases the amount of work your heart has to do. Diltiazem belongs to a group of medications called calcium channel blockers."
Answered by AI
Is diltiazem CD long acting?
"Diltiazem Long-Acting Capsules are used to treat high blood pressure and a type of long-term chest pain known as stable angina."
Answered by AI
What are the side effects of diltiazem CD 120 mg?
"Lightheadedness, dizziness, weakness, nausea, flushing, headache, and constipation may occur. If any of these effects persist or get worse, tell your doctor or pharmacist right away. To lower the risk of dizziness and lightheadedness, get up slowly when going from a sitting or lying down position."
Answered by AI