Dexlansoprazole

Q: What are the side effects of taking Dexilant?

<p>The following are some common reasons for belly <a href="https://www.withpower.com/clinical-trials/pain">pain</a>: diarrhea, flatulence (gas), nausea and vomiting, upper respiratory infections, such as the common cold.</p>

Heartburn, Erosive Esophagitis, Esophagitis

Treatment

6 FDA approvals

3 Active Studies for Dexlansoprazole

Treatment for

Heartburn

What is Dexlansoprazole

Dexlansoprazole

The Generic name of this drug

Treatment Summary

Dexlansoprazole is a medication used to reduce stomach acid and treat symptoms related to gastroesophageal reflux disease (GERD). It is a newer generation proton pump inhibitor (PPI), meaning it works by blocking the final step in gastric acid production. Dexlansoprazole has a unique pharmacokinetic profile compared to other PPIs due to its delayed-release and dual-delivery release system, resulting in two peak concentrations of the drug in the blood. It is generally well-tolerated, but long-term use of PPIs can lead to adverse effects such as an increased

Kapidex

is the brand name

image of different drug pills on a surface

Dexlansoprazole Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Kapidex

Dexlansoprazole

2009

Approved as Treatment by the FDA

Dexlansoprazole, also called Kapidex, is approved by the FDA for 6 uses including Symptomatic Non-erosive Gastroesophageal Reflux Disease and healed erosive esophagitis .

Symptomatic Non-erosive Gastroesophageal Reflux Disease

healed erosive esophagitis

Helps manage healed erosive esophagitis

Heartburn

Helps manage Heartburn

Heartburn

Helps manage Heartburn

Esophagitis

Helps manage healed erosive esophagitis

Erosive Esophagitis

Effectiveness

How Dexlansoprazole Affects Patients

Dexlansoprazole is a type of drug that reduces stomach acid production. It works by blocking the enzyme (H+, K+)-ATPase which is found on the surface of the stomach cells that produce acid.

How Dexlansoprazole works in the body

Dexlansoprazole works by blocking an enzyme called H/K ATPase. This enzyme is responsible for releasing hydrochloric acid into the stomach. It does this by exchanging hydrogen ions for potassium ions in the stomach. Dexlansoprazole works by attaching to the enzyme and blocking it from working. This prevents the release of hydrochloric acid, reducing both normal and stimulated acid secretion. The delivery of dexlansoprazole is designed to release the drug in two parts - one in the proximal duodenum and one in the small intestine.

When to interrupt dosage

The recommended dose of Dexlansoprazole is contingent upon the indicated condition, for example healed erosive esophagitis, symptomatic non-erosive gastroesphageal reflux disease and Heartburn. The amount of dosage fluctuates as per the technique of delivery (e.g. Capsule, delayed release or Tablet, orally disintegrating, delayed release) featured in the table beneath.

Condition

Dosage

Administration

Heartburn

, 30.0 mg, 60.0 mg

Oral, , Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release - Nasogastric; Oral, Nasogastric; Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral

Erosive Esophagitis

, 30.0 mg, 60.0 mg

Esophagitis

, 30.0 mg, 60.0 mg

Warnings

There are 20 known major drug interactions with Dexlansoprazole.

Common Dexlansoprazole Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Dexlansoprazole.

Atazanavir

Major

Dexlansoprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Dexlansoprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Dexlansoprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Dexlansoprazole.

Dexlansoprazole Toxicity & Overdose Risk

The highest non-toxic dose of Dexlansoprazole in mice, rats, and dogs is greater than 5,000mg/kg. Common side effects include diarrhea, abdominal pain, nausea, upper respiratory infections, vomiting, and gas. Serious cases of high blood pressure have been reported when taking twice daily doses of 60mg. Long-term toxicity studies of Dexlansoprazole using lansoprazole have shown that it can cause gastric cell hyperplasia and carcinoids, as well as increased instances of intestinal metaplasia in rats. It is not expected to have any effect on fertility or the

image of a doctor in a lab doing drug, clinical research

Dexlansoprazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Dexlansoprazole?

Seven active trials are evaluating the potential of Dexlansoprazole to provide therapeutic benefit for patients suffering from Erosive Esophagitis, healed erosive esophagitis and symptomatic non-erosive gastroesphageal reflux disease.

Condition

Clinical Trials

Trial Phases

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Esophagitis

0 Actively Recruiting

Dexlansoprazole Reviews: What are patients saying about Dexlansoprazole?

Patient Review

8/2/2011

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I've had GERD for eight years, and this is the first treatment that's really helped me. It's not perfect, but it's a marked improvement from where I was before. The cost is unfortunately prohibitive, but I'm hopeful that I can find a way to keep taking it.

Patient Review

1/7/2011

Dexlansoprazole for Stomach Ulcer

I have a stomach ulcer and this medication has been really helpful. It coated the ulcer and lowered the amount of acid building up, which resulted in less pain each day. I'm grateful to be on this drug as it's worked better than anything else I've tried for my ulcer.

Patient Review

8/20/2010

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication has been working to reduce my acid reflux. I have had trouble with my tongue, though.

Patient Review

12/11/2009

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I was very pleased that this worked the first time I tried it.

Patient Review

7/12/2009

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

This is the only medication I've tried that has worked. No more vomiting, nausea, throat pain, or acid. I've been using it for 8 weeks now and couldn't be happier.

Patient Review

10/6/2009

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I had been taking omeprazole for years and it was no longer taking care of my reflux disease. My doctor gave me some samples of the dexlansoprazole and it took care of my problem with 1 dose.

Patient Review

2/22/2013

Dexlansoprazole for Heartburn

I'm pretty disappointed with my insurance company. I have to pay 10x as much for my medication now. Not sure what to do about it.

Patient Review

9/6/2012

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

I've had a cough for the past two years, and was recently diagnosed with having two ulcers through my vocal cord lining. The medication has helped somewhat, but I find myself more forgetful now. Not sure if that's related to the meds or not.

Patient Review

7/25/2010

Dexlansoprazole for Condition in which Stomach Acid is Pushed Into the Esophagus

This medicationdid a decent job of controlling my acid reflux, but after about three weeks I started feeling really depressed. That was a new side effect for me, and it went away as soon as I stopped taking the pill.

2.3

Patient Review

12/26/2012

Dexlansoprazole for Stomach Ulcer

This medication gave me some very unwelcome side effects. I started having horrible nightmares and became depressed. It was really strange because that's not usually how I am at all. But as soon as I stopped taking the medication, those symptoms went away completely.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dexlansoprazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of taking Dexilant?

"The following are some common reasons for belly pain: diarrhea, flatulence (gas), nausea and vomiting, upper respiratory infections, such as the common cold."

Answered by AI

Is omeprazole and dexlansoprazole same?

"Prilosec (omeprazole) is effective in treating heartburn. Dexilant (dexlansoprazole), while also effective, can be quite expensive as it is only available in its brand name form."

Answered by AI

What is dexlansoprazole used for?

"Dexlansoprazole is a medication used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus. Dexlansoprazole is a proton pump inhibitor (PPI) that works by decreasing the amount of acid produced by the stomach."

Answered by AI

When is the best time to take dexlansoprazole?

"In general, the amount of medication that you take depends on the strength of the medicine.

This medication should be taken orally according to your doctor's directions, typically once a day. If your symptoms tend to happen after you eat, your doctor may tell you to take your dose before the same meal each day, in order to achieve the best results. The amount of medication you take generally depends on the strength of the drug."

Answered by AI