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What is Dexlansoprazole
DexlansoprazoleThe Generic name of this drug
Treatment SummaryDexlansoprazole is a medication used to reduce stomach acid and treat symptoms related to gastroesophageal reflux disease (GERD). It is a newer generation proton pump inhibitor (PPI), meaning it works by blocking the final step in gastric acid production. Dexlansoprazole has a unique pharmacokinetic profile compared to other PPIs due to its delayed-release and dual-delivery release system, resulting in two peak concentrations of the drug in the blood. It is generally well-tolerated, but long-term use of PPIs can lead to adverse effects such as an increased
Kapidexis the brand name
Dexlansoprazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kapidex
Dexlansoprazole
2009
21
Approved as Treatment by the FDA
Dexlansoprazole, also called Kapidex, is approved by the FDA for 3 uses including Heartburn and healed erosive esophagitis .Heartburn
Helps manage Heartburn
healed erosive esophagitis
Helps manage healed erosive esophagitis
Erosive Esophagitis
Effectiveness
How Dexlansoprazole Affects PatientsDexlansoprazole is a type of drug that reduces stomach acid production. It works by blocking the enzyme (H+, K+)-ATPase which is found on the surface of the stomach cells that produce acid.
How Dexlansoprazole works in the bodyDexlansoprazole works by blocking an enzyme called H/K ATPase. This enzyme is responsible for releasing hydrochloric acid into the stomach. It does this by exchanging hydrogen ions for potassium ions in the stomach. Dexlansoprazole works by attaching to the enzyme and blocking it from working. This prevents the release of hydrochloric acid, reducing both normal and stimulated acid secretion. The delivery of dexlansoprazole is designed to release the drug in two parts - one in the proximal duodenum and one in the small intestine.
When to interrupt dosage
The recommended dose of Dexlansoprazole is contingent upon the indicated condition, for example healed erosive esophagitis, symptomatic non-erosive gastroesphageal reflux disease and Heartburn. The amount of dosage fluctuates as per the technique of delivery (e.g. Capsule, delayed release or Tablet, orally disintegrating, delayed release) featured in the table beneath.Condition
Dosage
Administration
Heartburn
, 30.0 mg, 60.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Nasogastric; Oral, Capsule, delayed release - Nasogastric; Oral
healed erosive esophagitis
, 30.0 mg, 60.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Nasogastric; Oral, Capsule, delayed release - Nasogastric; Oral
Erosive Esophagitis
, 30.0 mg, 60.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Nasogastric; Oral, Capsule, delayed release - Nasogastric; Oral
Warnings
There are 20 known major drug interactions with Dexlansoprazole.Common Dexlansoprazole Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Dexlansoprazole.
Atazanavir
Major
Dexlansoprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Dexlansoprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Dexlansoprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Dexlansoprazole.
Dexlansoprazole Toxicity & Overdose RiskThe highest non-toxic dose of Dexlansoprazole in mice, rats, and dogs is greater than 5,000mg/kg. Common side effects include diarrhea, abdominal pain, nausea, upper respiratory infections, vomiting, and gas. Serious cases of high blood pressure have been reported when taking twice daily doses of 60mg. Long-term toxicity studies of Dexlansoprazole using lansoprazole have shown that it can cause gastric cell hyperplasia and carcinoids, as well as increased instances of intestinal metaplasia in rats. It is not expected to have any effect on fertility or the
Dexlansoprazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Dexlansoprazole?
Seven active trials are evaluating the potential of Dexlansoprazole to provide therapeutic benefit for patients suffering from Erosive Esophagitis, healed erosive esophagitis and symptomatic non-erosive gastroesphageal reflux disease.Condition
Clinical Trials
Trial Phases
healed erosive esophagitis
0 Actively Recruiting
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
Dexlansoprazole Reviews: What are patients saying about Dexlansoprazole?
5Patient Review
8/2/2011 I've had GERD for eight years, and this is the first treatment that's really helped me. It's not perfect, but it's a marked improvement from where I was before. The cost is unfortunately prohibitive, but I'm hopeful that I can find a way to keep taking it.
5Patient Review
1/7/2011 I have a stomach ulcer and this medication has been really helpful. It coated the ulcer and lowered the amount of acid building up, which resulted in less pain each day. I'm grateful to be on this drug as it's worked better than anything else I've tried for my ulcer.
5Patient Review
8/20/2010 This medication has been working to reduce my acid reflux. I have had trouble with my tongue, though.
5Patient Review
12/11/2009 I was very pleased that this worked the first time I tried it.
5Patient Review
7/12/2009 This is the only medication I've tried that has worked. No more vomiting, nausea, throat pain, or acid. I've been using it for 8 weeks now and couldn't be happier.
5Patient Review
10/6/2009 I had been taking omeprazole for years and it was no longer taking care of my reflux disease. My doctor gave me some samples of the dexlansoprazole and it took care of my problem with 1 dose.
4Patient Review
2/22/2013 I'm pretty disappointed with my insurance company. I have to pay 10x as much for my medication now. Not sure what to do about it.
3Patient Review
9/6/2012 I've had a cough for the past two years, and was recently diagnosed with having two ulcers through my vocal cord lining. The medication has helped somewhat, but I find myself more forgetful now. Not sure if that's related to the meds or not.
3Patient Review
7/25/2010 This medicationdid a decent job of controlling my acid reflux, but after about three weeks I started feeling really depressed. That was a new side effect for me, and it went away as soon as I stopped taking the pill.
2.3Patient Review
12/26/2012 This medication gave me some very unwelcome side effects. I started having horrible nightmares and became depressed. It was really strange because that's not usually how I am at all. But as soon as I stopped taking the medication, those symptoms went away completely.
Patient Q&A Section about dexlansoprazole
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking Dexilant?
"The following are some common reasons for belly pain: diarrhea, flatulence (gas), nausea and vomiting, upper respiratory infections, such as the common cold."
Answered by AI
Is omeprazole and dexlansoprazole same?
"Prilosec (omeprazole) is effective in treating heartburn. Dexilant (dexlansoprazole), while also effective, can be quite expensive as it is only available in its brand name form."
Answered by AI
What is dexlansoprazole used for?
"Dexlansoprazole is a medication used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus. Dexlansoprazole is a proton pump inhibitor (PPI) that works by decreasing the amount of acid produced by the stomach."
Answered by AI
When is the best time to take dexlansoprazole?
"In general, the amount of medication that you take depends on the strength of the medicine.
This medication should be taken orally according to your doctor's directions, typically once a day. If your symptoms tend to happen after you eat, your doctor may tell you to take your dose before the same meal each day, in order to achieve the best results. The amount of medication you take generally depends on the strength of the drug."
Answered by AI