Dexamethasone Intensol

Q: Does dexamethasone Intensol have alcohol?

<p>7</p> <p>This medication contains alcohol and dexamethasone. It is available in a 1mg/mL strength.</p>

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

106 FDA approvals

20 Active Studies for Dexamethasone Intensol

Treatment for

Pemphigus

What is Dexamethasone Intensol

Dexamethasone

The Generic name of this drug

Treatment Summary

Dexamethasone, also known by the brand name MK-125, is a steroid medication used to treat a wide variety of conditions, such as endocrine disorders, rheumatic diseases, allergic reactions, eye conditions, gastrointestinal issues, and breathing problems. This drug was developed in 1957 and was approved by the FDA in 1958. Recently, dexamethasone has been used to treat severe respiratory symptoms of COVID-19 and has been found to reduce deaths by approximately one-third in patients on ventilators and one-fifth in those requiring oxygen.

Decadron

is the brand name

image of different drug pills on a surface

Dexamethasone Intensol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 106 uses which include Adrenal cortical hypofunctions and severe Psoriasis .

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

severe Psoriasis

Helps manage severe Psoriasis

Acute Leukemia (Category)

Helps manage Acute Leukemia (Category)

Choroiditis

Helps manage Choroiditis

Drug Allergy

Helps manage Drug hypersensitivity reaction

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

Regional Enteritis

Helps manage Regional Enteritis

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Berylliosis

Helps manage Berylliosis

Seasonal Allergic Rhinitis

Helps manage Seasonal Allergic Rhinitis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Crohn Disease

Helps manage Regional Enteritis

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Cushing's Syndrome

Serum Sickness

Helps manage Serum Sickness

Mycosis Fungoides

Helps manage Mycosis Fungoides (MF)

Conjunctivitis

Helps manage anterior eye segment inflammation

Tennis Elbow

Helps manage Epicondylitis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Bursitis

Helps manage Bursitis

Cushing Syndrome

Anemia, Hemolytic

Helps manage acquired immune hemolytic anemia

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Multiple Myeloma (MM)

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Immune Thrombocytopenia (ITP)

Helps manage Immune Thrombocytopenia (ITP)

Iridocyclitis

Helps manage Iridocyclitis

Optic Neuritis

Helps manage Optic Neuritis

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Choroiditis

Helps manage Choroiditis

Tenosynovitis

Helps manage Tenosynovitis

Asthma

Helps manage Asthma

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Erythroblastopenia

Helps manage Erythroblastopenia

Hypercalcemia

Helps manage Hypercalcemia

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Keratitis

Helps manage Keratitis

Ulcerative Colitis

Helps manage Ulcerative Colitis

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Adrenal Gland Hyperfunction

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

Adrenocortical Hyperfunction

Inflammation

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Epicondylitis

Helps manage Epicondylitis

Cancer

Helps manage Cancer

Trichinosis

Helps manage Trichinosis

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Berylliosis

Helps manage Berylliosis

Synovitis

Helps manage Synovitis

Acute Coryza

Helps manage acute rheumatic carditis

Drug hypersensitivity reaction

Helps manage Drug hypersensitivity reaction

Edema of the cerebrum

Helps manage Edema of the cerebrum

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Atopic Dermatitis

Helps manage Atopic Dermatitis

Severe Seborrheic Dermatitis

Helps manage Severe Seborrheic Dermatitis

Malignant Lymphomas

Helps manage Malignant Lymphomas

exfoliative erythroderma

Helps manage exfoliative erythroderma

Systemic Lupus Erythematosus (SLE)

Helps manage Systemic Lupus Erythematosus (SLE)

Optic Neuritis

Helps manage Optic Neuritis

Synovitis

Helps manage Synovitis

Congenital Adrenal Hyperplasia (CAH)

Helps manage Congenital Adrenal Hyperplasia (CAH)

Bursitis

Helps manage Bursitis

Ankylosing Spondylitis (AS)

Helps manage Ankylosing Spondylitis (AS)

Sarcoidosis

Helps manage Sarcoidosis

Uveitis

Helps manage Uveitis

Chorioretinitis

Helps manage Chorioretinitis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

non-suppurative Thyroiditis

Helps manage non-suppurative Thyroiditis

Contact Dermatitis

Helps manage Contact Dermatitis

Tuberculosis

Helps manage Tuberculosis (TB)

Loeffler's syndrome

Helps manage Loeffler's syndrome

Pemphigus

Helps manage Pemphigus

Uveitis

Helps manage Uveitis

Iritis

Helps manage Iritis

Acute Gouty Arthritis

Helps manage Acute Gouty Arthritis

Hypercalcemia

Helps manage Hypercalcemia

Asthma

Helps manage Asthma

Rosacea

Helps manage Rosacea

Posttraumatic Osteoarthritis

Helps manage Posttraumatic Osteoarthritis

Brain

Helps manage Edema of the cerebrum

Inflammation

Iridocyclitis

Helps manage Iridocyclitis

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Ulcerative Colitis

Helps manage Ulcerative Colitis

Iritis

Helps manage Iritis

Pulmonary Eosinophilia

Helps manage Loeffler's syndrome

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Anemia, Diamond-Blackfan

Helps manage Congenital Hypoplastic Anemia

Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Rosacea

Helps manage Rosacea

Multiple Myeloma

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Thrombocytopenia

Helps manage Secondary thrombocytopenia

Pemphigus

Helps manage Pemphigus

Thyroiditis

Helps manage non-suppurative Thyroiditis

Psoriasis

Helps manage severe Psoriasis

Effectiveness

How Dexamethasone Intensol Affects Patients

Corticosteroids are medications that stop inflammation in the body. Dexamethasone's effects last for different lengths of time depending on how it is taken. Corticosteroids can be taken in much higher doses than the body naturally produces. It is important to talk to a doctor about the risks associated with taking corticosteroids, such as a weakened immune system and increased risk of infection.

How Dexamethasone Intensol works in the body

Corticosteroids help decrease inflammation by narrowing blood vessels and stopping white blood cells from rushing to the site of inflammation. They also promote anti-inflammatory genes and stop the formation of certain molecules that cause inflammation. Low doses of corticosteroids can reduce inflammation, while higher doses can suppress the immune system. When taken for a long time, corticosteroids can also increase sodium levels and decrease potassium levels.

When to interrupt dosage

The suggested dose of Dexamethasone Intensol is contingent upon the diagnosed condition, such as Pink Eye, Brain and Keloids Scars. The amount of dosage alters, in accordance with the technique of delivery noted in the table below.

Condition

Dosage

Administration

Chorioretinitis

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Intravitreal, Implant - Intravitreal, Implant, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Ointment, Ointment - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Ophthalmic, Solution / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Suspension / drops, Solution, Solution - Ophthalmic, Suspension - Auricular (otic), Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Injection, Elixir, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intravenous, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Suspension / drops - Ophthalmic, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution - Oral, Solution, concentrate - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Auricular (otic); Ophthalmic, Solution - Parenteral, Injection, solution - Ophthalmic, Topical, Solution / drops - Topical, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intrasynovial; Intravenous, Liquid - Dental, Elixir - Oral, Intraocular, Injection, solution - Intraocular, Injection, suspension, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Liquid - Intramuscular; Intrasynovial; Intravenous, Solution - Intra-articular; Intramuscular; Intravenous, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Parenteral, Injection, suspension - Intraocular, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Solution - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Insert - Ophthalmic, Insert, Perineural, Suspension / drops - Topical

Pink Eye

Bacterial Infections

Communicable Diseases

swelling of the eyes

Eye

Otitis

Skin Diseases

Communicable Diseases

Rheumatoid Arthritis

Urinary Tract Infection (UTI)

Ophthalmic Surgery

Crohn Disease

Acute Myeloid Leukemia (AML)

Sarcoidosis

Fluorophotometry

Uveitis

Ocular Infections, Irritations and Inflammations

Aspiration Pneumonitis

Retinal Vein Occlusion

Warnings

Dexamethasone Intensol has nineteen contraindications. It should not be consumed while enduring any of the ailments enumerated in the following table.

Dexamethasone Intensol Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

Chickenpox

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

Eye Infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Dexamethasone Intensol.

Common Dexamethasone Intensol Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Dexamethasone Intensol Toxicity & Overdose Risk

The most toxic dose of glucocorticoids for female mice is 6.5g/kg when taken orally and 794mg/kg through an intravenous route. It is unlikely that overdosing on otic formulations will occur. Taking glucocorticoids in excess over a long period of time can lead to cataracts, glaucoma, high blood pressure, water retention, high cholesterol, ulcers, pancreatitis, muscle diseases, changes in mood or behavior, skin thinning, allergies, acne, excessive hair growth, weakened immune system, difficulty fighting infection, moon face, high blood sugar, low calcium

image of a doctor in a lab doing drug, clinical research

Dexamethasone Intensol Novel Uses: Which Conditions Have a Clinical Trial Featuring Dexamethasone Intensol?

Currently, 345 active trials are being conducted to investigate the potential of Dexamethasone Intensol in the management of Eye Infections, Stevens-Johnson Syndrome and Chorioretinitis.

Condition

Clinical Trials

Trial Phases

Rheumatoid Arthritis

56 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Asthma

91 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Acute Coryza

0 Actively Recruiting

Thyroiditis

0 Actively Recruiting

Lupus

66 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Trichinosis

0 Actively Recruiting

Diabetic Macular Edema

21 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Inflammation

57 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Tuberculosis

2 Actively Recruiting

Phase 3, Phase 2

Pulmonary Eosinophilia

8 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 1

Open-angle glaucoma

45 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1

Uveitis

3 Actively Recruiting

Not Applicable, Phase 3

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Acute Myeloid Leukemia (AML)

32 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3

Thrombocytopenia

0 Actively Recruiting

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Bacterial Infections

0 Actively Recruiting

Atopic Dermatitis

10 Actively Recruiting

Phase 2, Phase 3, Phase 4

Skin Diseases

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Dexamethasone Intensol Reviews: What are patients saying about Dexamethasone Intensol?

Patient Review

4/4/2010

Dexamethasone Intensol for Inflammation of the Artery in the Temple Area

This medication has been a complete game-changer for me. Not only does it help to prevent migraines, but it's also helped clear up my skin!

Patient Review

9/5/2019

Dexamethasone Intensol for Psoriasis associated with Arthritis

This medication was a saving grace. I had terrible protein levels in my blood and could hardly work three years ago. I started taking this drug and within one week, felt so much better that I was able to return to full-time work.

4.3

Patient Review

9/25/2010

Dexamethasone Intensol for Cancer of the Prostate Gland

This medication has helped with my breathing problems.

3.3

Patient Review

10/15/2009

Dexamethasone Intensol for A Tumor Formed of Blood Vessels

This medication has been helpful in treating my lung tumor alongside chemotherapy.

1.7

Patient Review

6/5/2011

Dexamethasone Intensol for Muscle Pain and Stiffness in Shoulder, Neck and Pelvis

This medication led to me becoming very constipated.

1.3

Patient Review

6/21/2013

Dexamethasone Intensol for Allergic Reaction caused by a Drug

This treatment wasn't effective for me.

Patient Review

9/30/2013

Dexamethasone Intensol for Skin Condition

I was trying to clear up a skin condition, but not only did it not work, I also started losing lots of hair. If I had known about this side effect, I would have never taken the drug in the first place.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dexamethasone intensol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is liquid dexamethasone used for?

"It works on the immune system to help reduce inflammation and swelling.

Dexamethasone is a Corticosteroid that can be used to help reduce Inflammation and swelling caused by a number of conditions such as; allergies, arthritis, asthma, blood or bone marrow problems, kidney problems, skin conditions, and flare-ups of multiple sclerosis."

Answered by AI

Does dexamethasone Intensol have alcohol?

This medication contains alcohol and dexamethasone. It is available in a 1mg/mL strength."

Answered by AI

What is dexamethasone Intensol used for?

"Some conditions that dexamethasone is used to treat are arthritis, blood/hormone disorders, allergic reactions, skin diseases, eye problems, breathing problems, bowel disorders, cancer, and immune system disorders. Additionally, dexamethasone can be used as a test for an adrenal gland disorder known as Cushing's syndrome."

Answered by AI

What are the side effects of dexamethasone?

"You may experience an upset stomach, stomach irritation, vomiting, headache, dizziness, insomnia, restlessness, or depression while taking this medication."

Answered by AI

Clinical Trials for Dexamethasone Intensol

Image of The Royal Alexandra Hospital in Edmonton, Canada.

Graft Selection for Glaucoma Surgery

18 - 110

All Sexes

Edmonton, Canada

Glaucoma refers to a group of progressive optic neuropathies that lead to permanent vision loss. Glaucoma is the leading cause of irreversible blindness globally. In 2020, it was estimated to affect 76 million individuals worldwide, with projections indicating this number will rise to 111.8 million by 2040. In Canada, glaucoma affects an estimated 2.7-7.5% of individuals over the age of 50, contributing substantially to the national disease burden. This condition is linked to damage of the optic nerve due to elevated intraocular pressure (IOP; raised eye pressure), which results in the loss of retinal ganglion cells. Therefore, most of the treatments are guided towards reducing the IOP either via using laser, medications or surgery. Glaucoma surgery is typically reserved for cases where IOP remains uncontrolled while on maximum tolerated medical therapy and/or where glaucoma progression warrants surgery. The goal of many glaucoma surgeries is to divert aqueous humor from the anterior chamber to the subconjunctival space, therefore reducing intraocular pressure. The device used for this purpose are the PRESERFLO™ MicroShunt (Glaukos Corporation, Laguna Hills, CA, USA) (we will interchangeably use terms "stent" and "shunt" to refer to these devices in the text below). The device is implanted using the ab externo approach to channel fluid from the anterior chamber to the subconjunctival/subtenon space. To reduce postoperative fibrosis and inhibit fibroblast activity that could obstruct flow and lead to device failure, 5-fluorouracil (5-FU) or mitomycin C (MMC) are administered. Additionally, a double-layered closure of conjunctiva and Tenon's is performed to minimize Tenon's migration and blockage of tenon the stents. Despite these measures, stent encapsulation and failure are still too common requiring revisions and bleb needling in 2-20% of cases within the first 12 months of follow-up. This project will involve a series of studies evaluating graft selection in PreserFlo MicroShunt implantation, focusing on donor sclera, cornea, and pericardium as patch graft materials. First, we will conduct a prospective, randomized study comparing clinical outcomes between these graft types. Outcomes of interest will include surgical success rates, post-operative hypotony, tube erosion, conjunctival complications, infection, and overall device longevity. Donor sclera has long been used as a patch graft in glaucoma drainage device surgery and is associated with low erosion rates and reliable long-term results. Corneal tissue is increasingly used due to its transparency and availability through eye banks, with demonstrated safety in ocular surface reconstruction and tube coverage. Pericardium is another durable, biocompatible option, historically applied in both cardiovascular and ocular surgery, and has shown effectiveness as a patch graft in glaucoma drainage implants. This comparison will extend to both primary implantation and revision surgeries, recognizing the high clinical relevance of graft performance in complex cases. Building on these results, we will then perform a cost-effectiveness analysis of graft strategies, incorporating surgical time, post-operative management, complication rates, and need for re-operation. An economic model will be developed to evaluate costs and resource utilization associated with each material, providing valuable data for policy and surgical decision-making. Finally, we will conduct a patient-reported outcome (PRO) study to assess patient comfort and satisfaction with different grafts. Surveys will evaluate domains such as foreign body sensation, cosmesis, and overall satisfaction at key time points (immediate post-operative period, 1 week, 3 weeks, and 3 months). These results will highlight the patient perspective, an often underrepresented but critical factor in surgical innovation. Together, these studies will comprehensively assess graft selection from surgical, economic, and patient-centered perspectives, informing evidence-based practice in glaucoma care.

Waitlist Available

Has No Placebo

The Royal Alexandra Hospital

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Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+

All Sexes

Toronto, Canada

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What the Investigators Think: The investigators believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What the Investigators are Doing: The investigators will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing the investigators will look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. The investigators will also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: The investigators have already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. The investigators have also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, the investigators need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.

Phase 4

Waitlist Available

Has No Placebo

Sunnybrook Health Sciences Centre (+4 Sites)