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What is Desvenlafaxine Succinate
DesvenlafaxineThe Generic name of this drug
Treatment SummaryDesvenlafaxine is an antidepressant medication used to treat major depressive disorder. It works by preventing serotonin and norepinephrine from being reabsorbed by the brain. It is available in extended release tablet form and was approved by the FDA in 2008.
Pristiq Extended-Releaseis the brand name
Desvenlafaxine Succinate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pristiq Extended-Release
Desvenlafaxine
2008
87
Approved as Treatment by the FDA
Desvenlafaxine, also known as Pristiq Extended-Release, is approved by the FDA for 1 uses including Depression .Depression
Effectiveness
How Desvenlafaxine Succinate Affects PatientsDesvenlafaxine is a drug that works on certain chemicals in the brain (serotonin and norepinephrine) to help with depression. It does not interact with most other drugs, and its dose does not need to be adjusted much. It does not affect the activity of certain receptors, ion channels, or an enzyme called MAO. It also has no effect on the hERG potassium channel, which is important to the heart. Compared to other SNRIs, desvenlafaxine is easier to take as it does not have to be adjusted much and rarely interacts with other drugs.
How Desvenlafaxine Succinate works in the bodyDesvenlafaxine works by blocking the reuptake of serotonin, norepinephrine, and dopamine in the brain. It does this more effectively for serotonin than norepinephrine, and least effectively for dopamine. It doesn't interact with any other receptors or enzymes in the body.
When to interrupt dosage
The proposed dosage of Desvenlafaxine Succinate is contingent upon the determined condition, such as Menopause, Hot Flashes and Depression. The amount of dosage fluctuates, depending on the mode of delivery specified in the table hereunder.Condition
Dosage
Administration
Depression
, 25.0 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Hot Flashes
, 25.0 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Hot flashes
, 25.0 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Desvenlafaxine Succinate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Desvenlafaxine may interact with Pulse Frequency
Common Desvenlafaxine Succinate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Desvenlafaxine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Desvenlafaxine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Desvenlafaxine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Desvenlafaxine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Desvenlafaxine.
Desvenlafaxine Succinate Toxicity & Overdose RiskDesvenlafaxine can be found in breast milk, so nursing mothers must decide whether to continue taking the drug or discontinue breast feeding based on the potential risks and benefits to both mother and child.
Desvenlafaxine Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Desvenlafaxine Succinate?
219 active clinical trials are currently being conducted to investigate the potential of Desvenlafaxine Succinate in alleviating Hot Flashes, Depression and Menopause symptoms.Condition
Clinical Trials
Trial Phases
Hot Flashes
14 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Desvenlafaxine Succinate Reviews: What are patients saying about Desvenlafaxine Succinate?
5Patient Review
6/25/2022 I've been on antidepressants for a very long time, and this is by far the best one I've tried. Recently, my husband was having some issues with other medications, but once he switched to desvenlafaxine he was back to normal. I'm really happy with the results.
5Patient Review
4/29/2022 I felt like a new person after taking this drug. I had so much more energy and didn't feel exhausted all the time. The only downside is that it caused some insomnia, but nothing that a low dose of Seroquel couldn't help with.
5Patient Review
4/29/2022 I felt like a new person after taking this drug. I had so much more energy and didn't feel tired all the time. The only downside was that it made it harder for me to sleep, but a low dose of Seroquel helped with that.
5Patient Review
10/20/2022 I had struggled for a long time with anxiety and low moods, but this treatment has been life-changing. It's helped ease my anxiety to the point where I can actually function again.
5Patient Review
6/25/2022 Desvenlafaxine has been a game-changer for my husband's mental health. He's been on other antidepressants in the past, but this one has really helped him get back to his old self. I'm extremely happy with the results.
5Patient Review
10/20/2022 I had really bad anxiety and low moods but this has been very beneficial and has eased my anxiety tremendously. I was previously on Lexapro and Wellbutrin which has a negative impact on me and seemed to not help as much. This did the trick so far. I still get anxious every once in a while but I am better able to handle it and it only lasts a couple of hours vs the whole day.
5Patient Review
4/29/2022 I had lost energy for years and felt like a zombie, but this treatment has helped me feel like my old self again. The only downside is that it disrupts my sleep, but a low dose of Seroquel takes care of that.
5Patient Review
8/28/2022 This medication was a godsend. It helped me out of my depression and I'm extremely grateful for it.
5Patient Review
10/20/2022 This treatment has been greatly beneficial in easing my anxiety and low moods. I was previously on Lexapro and Wellbutrin, but this medication has helped me much more effectively.
5Patient Review
6/25/2022 Desvenlafaxine has been a total game-changer for my husband's depression and anxiety. He's doing so much better since switching to this medication, and I'm really happy about it.
5Patient Review
8/28/2022 This medication was hugely beneficial for my depression.
5Patient Review
8/28/2022 This medication was wonderful and helped my depression a lot.
4.7Patient Review
6/9/2022 Worked very quickly and had a big impact. Each medication affects people differently, so it's important to keep that in mind when trying new treatments. This one worked extremely well for me.
4.7Patient Review
9/6/2022 It took a few months to see full results, but it was worth sticking with it. I found that my anxiety, depression, and triggers have all calmed down significantly. The only downside is that you feel withdrawal pretty quickly if you forget to take your dose. Overall, I highly recommend this medication.
4.7Patient Review
6/9/2022 Worked very quickly and had a big impact. Different medications work differently for different people; this one was great for me.
4.7Patient Review
9/6/2022 I stuck with this treatment for several months, and it's really paid off. I'm now feeling much calmer and happier on a day-to-day basis. The withdrawal symptoms the next day if you forget to take your dose are pretty intense, though. All in all, I would definitely recommend this medication to others dealing with similar issues.
4.7Patient Review
9/6/2022 It took a few months to see full benefits, but now that I've stuck with it, my anxiety and triggers have calmed down significantly. My mood has also improved overall. The only downside is that you feel withdrawal pretty quickly if you forget to take it, which can be a reminder in itself. Overall, I would highly recommend this medication.
4.7Patient Review
6/9/2022 Worked very quickly and had a big impact. It's important to remember that each person reacts to medication differently; this one was amazing for me, but it might not be the same for everyone.
4.3Patient Review
4/18/2022 This treatment has done wonders for my quality of life. I highly recommend it to anyone struggling with Depersonalization/Derealization.
4.3Patient Review
4/18/2022 I've had a tough time with Depersonalization/Derealization, but this treatment has lightened the load. I'm feeling better and more hopeful now.
4.3Patient Review
4/18/2022 I've had a lot of success with this treatment in improving my quality of life. It can be tough to keep hope alive when struggling with mental health, but please don't give up and know that there are treatments out there that can help!
4Patient Review
3/25/2022 Pristiq has been the most effective out of all the different drugs I've tried for my depression.
4Patient Review
3/25/2022 I've been on Pristiq for a decade, and it's by far the best medication I've tried to manage my depression.
4Patient Review
3/25/2022 Pristiq has been the most effective drug I've tried for my depression, and I've been on it for over 10 years.
3Patient Review
10/14/2022 I was really hoping this would be the one, but unfortunately it didn't work out. I felt better for a little while, but now I'm back to feeling terrible again. I'm switching to Paxil now in the hopes that it will be more effective.
3Patient Review
10/14/2022 I was really hoping this would work because it did show some promise at first, but eventually my depression came back worse than ever. I'm now switching to Paxil in the hopes that it will be more effective.
3Patient Review
10/14/2022 I gave this treatment a chance, but unfortunately it didn't work out in the end. I felt better for a little while, but now I'm back to feeling just as depressed as before.
1.3Patient Review
3/3/2022 I experienced none of the benefits I was hoping for, but unfortunately got all of the terrible side-effects. By far the worst medication I've ever taken.
1.3Patient Review
3/3/2022 I experienced literally none of the benefits, but I got all of the terrible side-effects. This was by far the worst medication I've ever taken.
1.3Patient Review
3/3/2022 I experienced only negative effects from this medication, which has been the worst I've ever taken.
1Patient Review
9/13/2022 I don't see the point of this treatment. It seems like I'll have to rely on it forever, and that's not really living. There's no endgame here, and that's really frustrating.
1Patient Review
3/4/2022 I experienced a lot of negative side effects from this medication, to the point where it felt poisonous. I couldn't sleep and it was easily the worst out of all the medications I've tried.
1Patient Review
7/30/2022 I had terrible side effects from this drug and it made my anxiety worse. I could only take it for four days before I had to stop taking it.
1Patient Review
3/4/2022 The side effects of this drug are really terrible. It feels like poison, and I can't even sleep. Out of all the drugs I've tried, this one is by far the worst.
1Patient Review
9/13/2022 I find myself wondering what the long-term goal is for taking this medication. Am I always going to have to rely on it? And if so, what kind of life is that? A half-life? There are no surgical options and talking doesn't help, so it seems like the only choice is to medicate and deal with all the side effects.
1Patient Review
7/30/2022 Unfortunately, this medication made my symptoms worse. I was shaking and felt very nervous. Side effects were too much to handle, so I had to stop taking it after just four days.
1Patient Review
3/4/2022 All I experienced were side effects from this drug. It felt like poison to me and I couldn't sleep at all while taking it. Out of all the medications I've tried, this was by far the worst.
1Patient Review
7/30/2022 I really disliked this drug. It made me feel worse and I experienced some terrible side effects. Shaking and nervousness were the primary problems, but I also felt generally awful while taking it. Thankfully, I only had to endure four days of this before getting off the medication.
1Patient Review
9/13/2022 I don't see the point of this treatment. Do I have to rely on it forever because I can't be happy without it? It feels like I'm just numbing myself to life with all these side effects.
Patient Q&A Section about desvenlafaxine succinate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is desvenlafaxine used for anxiety?
"Although Pristiq (desvenlafaxine) is not officially approved to treat anxiety by the FDA, it is commonly used as an unapproved medication to manage generalized anxiety, social anxiety, and panic attacks."
Answered by AI
Is desvenlafaxine a strong antidepressant?
"The drug Desvenlafaxine does not work via a unique mechanism; rather, it is the active ingredient of the drug Venlafaxine. It has been created in the form of a tablet meant to be taken over a long period of time. There is no evidence that this drug is more effective than any other antidepressant, or that it has any other advantages over Venlafaxine."
Answered by AI
Does desvenlafaxine succinate make you gain weight?
"The average weight gain for people taking Pristiq in a long-term study was less than 2.2 pounds, which is the same result seen in people taking a placebo during the study. The review found that less than 1% of people taking Pristiq during clinical studies had a significant change in their weight."
Answered by AI
What is desvenlafaxine succinate used for?
"Desvenlafaxine is used to treat depression by increasing the amounts of serotonin and norepinephrine in the brain, natural substances that help maintain mental balance."
Answered by AI