Deferasirox

Blood Transfusions, Non-transfusion Dependent Thalassemia, Iron Overload
Treatment
0 Active Studies for Deferasirox

What is Deferasirox

DeferasiroxThe Generic name of this drug
Treatment SummaryDeferasirox is a medication used to help reduce the amount of iron in the body in patients who receive long-term blood transfusions. It is the first oral medication to be approved by the FDA for this purpose.
Exjadeis the brand name
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Deferasirox Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Exjade
Deferasirox
2005
112

Effectiveness

How Deferasirox Affects PatientsDeferasirox is an oral medication that binds to iron in the body. It has a strong attraction to iron, and it can also have a mild effect on zinc and copper levels. It is not yet clear what the implications of this decrease in zinc and copper levels may be.
How Deferasirox works in the bodyDeferasirox binds to and removes iron from the body. It has a strong attraction to trivalent (ferric) iron, which it binds to and forms a stable complex with. This complex is then removed when you urinate.

When to interrupt dosage

The amount of Deferasirox is contingent upon the determined disorder, including Iron Overload, Blood Transfusions and Non-transfusion Dependent Thalassemia. Dosage is also contingent upon the method of delivery (e.g. Granule or Tablet, film coated) stated in the table beneath.
Condition
Dosage
Administration
Blood Transfusions
125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg
, Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated - Oral, Tablet, coated
Non-transfusion Dependent Thalassemia
125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg
, Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated - Oral, Tablet, coated
Iron Overload
125.0 mg, , 250.0 mg, 500.0 mg, 90.0 mg, 180.0 mg, 360.0 mg
, Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Granule, Granule - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Deferasirox Contraindications
Condition
Risk Level
Notes
Advanced Malignancies
Do Not Combine
High-risk Myelodysplastic Syndrome (MDS)
Do Not Combine
Poor Performance Status
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Deferasirox.
Common Deferasirox Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Deferasirox.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Deferasirox.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Deferasirox.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Deferasirox.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Deferasirox.
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Deferasirox Novel Uses: Which Conditions Have a Clinical Trial Featuring Deferasirox?

There are currently no active studies examining the potential of Deferasirox for treatment of Blood Transfusions, Non-transfusion Dependent Thalassemia and Iron Overload Syndrome.
Condition
Clinical Trials
Trial Phases
Blood Transfusions
0 Actively Recruiting
Iron Overload
0 Actively Recruiting
Non-transfusion Dependent Thalassemia
0 Actively Recruiting

Deferasirox Reviews: What are patients saying about Deferasirox?

5Patient Review
10/2/2009
Deferasirox for Too Much Iron in the Blood for a Long Period of Time
1Patient Review
1/12/2021
Deferasirox for excess iron in person with non-transfusion-dependent thalassemia (NTDT)
Even after two weeks of taking this medication, I am still experiencing negative side effects. Recently, I had to go to the hospital for treatment.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about deferasirox

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When do you give deferasirox?

"It is recommended to take deferasirox once a day, at least 30 minutes before eating, either on an empty stomach or with a light meal."

Answered by AI

What is the generic name for deferasirox?

"Exjade is a prescription medicine used to treat the symptoms of Iron Overload in the blood. It can be used to treat Transfusional Hemosiderosis or Nontransfusion-Dependent Thalassemia."

Answered by AI

What are the side effects of deferasirox?

"The symptoms of this condition include nausea, vomiting, stomach/abdominal pain, diarrhea, dizziness, anxiety, tiredness, and sleep problems."

Answered by AI

What is deferasirox used to treat?

"Deferasirox is a drug used to remove excess iron from the body in patients who have had too many blood transfusions, or in patients with non-transfusion dependent thalassemia syndromes. Deferasirox is an iron chelator, which means it binds to iron in the blood."

Answered by AI
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