Dapsone

Toxoplasmosis, prophylaxis of mild Toxoplasma gondii encephalitis, prophylaxis of moderate Toxoplasma gondii encephalitis + 14 more
Treatment
20 Active Studies for Dapsone

What is Dapsone

DapsoneThe Generic name of this drug
Treatment SummarySulfone is a type of antibiotic that is effective against a wide range of bacteria, but mainly used to treat Mycobacterium leprae. It works by stopping the bacteria from producing folic acid, which is necessary for growth. Sulfone is also used in combination with pyrimethamine to treat malaria.
Dapsoneis the brand name
image of different drug pills on a surface
Dapsone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dapsone
Dapsone
1979
46

Effectiveness

How Dapsone Affects PatientsDapsone is a medication that has anti-inflammatory, antibacterial, and antibiotic properties. It is used to treat leprosy, malaria, and AIDS-related Pneumocystic carinii pneumonia. After taking it orally, it is quickly absorbed and spread throughout the body. It tends to remain in the skin, muscles, liver, and kidneys for up to three weeks after the treatment has stopped.
How Dapsone works in the bodyDapsone stops bacteria from multiplying by blocking the production of an important molecule. The way it works to reduce inflammation is unclear.

When to interrupt dosage

The suggested dosage of Dapsone is determined by the diagnosed condition, such as moderate Pneumocystis pneumonia, Relapsing Polychondritis and prophylaxis of mild Pneumocystis pneumonia. The dosage fluctuates based on the administration technique (e.g. Gel - Topical or Topical) demonstrated in the table underneath.
Condition
Dosage
Administration
moderate Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of moderate Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Drug Resistance
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of moderate Toxoplasma gondii encephalitis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Toxoplasmosis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Bullous Systemic Lupus Erythematosus
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
mild Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Bullous dermatitis herpetiformis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of mild Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pemphigus Vulgaris
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Toxoplasmosis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Immune thrombocytopenic purpura
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Acne Vulgaris
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of mild Toxoplasma gondii encephalitis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Hansen's Disease
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
HIV
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Relapsing Polychondritis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Dapsone.
Common Dapsone Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Dapsone.
Acepromazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Aceprometazine.
Acetophenazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Acetophenazine.
Alimemazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Alimemazine.
Dapsone Toxicity & Overdose RiskTaking too much of this drug may cause clogged sinuses, fainting, or hallucinations. If needed, measures should be taken to maintain normal blood pressure.
image of a doctor in a lab doing drug, clinical research

Dapsone Novel Uses: Which Conditions Have a Clinical Trial Featuring Dapsone?

144 active clinical trials are exploring the utility of Dapsone in alleviating Bullous Systemic Lupus Erythematosus, mild Pneumocystis pneumonia and Immune Thrombocytopenic Purpura.
Condition
Clinical Trials
Trial Phases
prophylaxis of mild Toxoplasma gondii encephalitis
0 Actively Recruiting
prophylaxis of mild Pneumocystis pneumonia
0 Actively Recruiting
Bullous dermatitis herpetiformis
0 Actively Recruiting
Acne Vulgaris
19 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3
prophylaxis of moderate Toxoplasma gondii encephalitis
0 Actively Recruiting
moderate Pneumocystis pneumonia
0 Actively Recruiting
prophylaxis of moderate Pneumocystis pneumonia
0 Actively Recruiting
Hansen's Disease
0 Actively Recruiting
Bullous Systemic Lupus Erythematosus
0 Actively Recruiting
mild Pneumocystis pneumonia
0 Actively Recruiting
Drug Resistance
0 Actively Recruiting
Toxoplasmosis
0 Actively Recruiting
Relapsing Polychondritis
0 Actively Recruiting
Immune thrombocytopenic purpura
0 Actively Recruiting
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Toxoplasmosis
0 Actively Recruiting
Pemphigus Vulgaris
2 Actively Recruiting
Phase 3, Phase 2

Dapsone Reviews: What are patients saying about Dapsone?

5Patient Review
3/18/2014
Dapsone for PCP Prophylaxis
Dapsone has been a real life-saver for me. It's prevented PCP (a type of pneumonia) for the last three months, and I have no negative side effects to report.
5Patient Review
10/10/2015
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
Dapsone has completely changed my life for the better. I was diagnosed with DH 24 years ago and have been taking half a 100mg tablet ever since then. It's great, but you can't take NSAIDs while on it because it'll make your symptoms 10 times worse.
5Patient Review
5/19/2013
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
Dapsone has been a godsend for me. It's prevented my disease from flaring up and causing me pain, and as an added bonus, it keeps my skin clear!
5Patient Review
2/22/2016
Dapsone for Disease of the Skin Characterized by Pus-Filled Blisters
Dapsone has been a very effective treatment for me. I've been taking it for over 10 years now with great results.
3.7Patient Review
4/2/2017
Dapsone for Inflammation of Several Cartilages of the Body
I was on 100 mg twice a day. I ended up in the hospital with Methemoglobinemia, which is a rare side effect of Dapsone. Until that point, my pain and swelling were relatively controlled.
3.3Patient Review
11/12/2014
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
Worked great for DH, but then my neutrophil count dropped and I had to stop using it due to the risk of infection. Now I'm stuck with an intense itch that won't go away. If anyone has any suggestions, please let me know!
3Patient Review
6/8/2018
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
I unfortunately had a lot of side effects from this treatment, including stomach issues and muscle soreness. I only took three pills and felt like I was back on chemo. It's effective but not worth how sick it made me.
2Patient Review
12/1/2016
Dapsone for Disease of the Mouth and Eyes Marked by Blisters
Dapsone was prescribed to me for pemphigoid. It caused a reduction in red blood cells, anemia and yellowing of skin. I was reduced from one to 50mg, which made me tired and fatigued. Now I'm forgetful and anxious. The blisters have been reduced but never gone away. I didn't expect the mental effects. Worried because I have important job and am not old.
2Patient Review
1/1/2016
Dapsone for PCP Prophylaxis
I had a really tough time with shortness of breath while taking Dapsone. Once I stopped the drug at my doctor's recommendation, it still took over a week for things to get back to normal.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dapsone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of dapsone?

"stomach pain and nausea, vomiting, headache, dizzinessCan result in blurred vision, ringing in your ears, and sleep problems (insomnia)"

Answered by AI

Is dapsone good for acne?

"Aczone is a medication that can be used to treat acne on the face and body. It is particularly effective for inflammatory acne breakouts, but can also be somewhat effective for non-inflammatory breakouts like blackheads and milia."

Answered by AI

Is dapsone an immunosuppressant?

"Dapsone is a small molecule that has anti-inflammatory, immunosuppressive, antibacterial, and antibiotic properties. It is used clinically to treat leprosy and malaria, and is being investigated for the treatment of a variety of skin infections."

Answered by AI

What type of antibiotic is dapsone?

"Dapsone is a medication used to treat acne that is caused by bacteria. It is classified as a sulfone antibiotic and works by slowing or stopping the growth of bacteria and decreasing inflammation."

Answered by AI

Clinical Trials for Dapsone

Have you considered Dapsone clinical trials? We made a collection of clinical trials featuring Dapsone, we think they might fit your search criteria.
Have you considered Dapsone clinical trials? We made a collection of clinical trials featuring Dapsone, we think they might fit your search criteria.
Have you considered Dapsone clinical trials? We made a collection of clinical trials featuring Dapsone, we think they might fit your search criteria.