What is Corlanor
IvabradineThe Generic name of this drug
Treatment SummaryIvabradine, also known by the brand name Corlanor, is a medication used to reduce heart rate and treat stable angina pectoris and chronic heart failure. It was approved by the FDA in 2015 and is now also used to treat symptomatic heart failure from dilated cardiomyopathy in patients over 6 months old. Ivabradine works by blocking a specific channel in the sinoatrial node, causing a slower heart rate and more blood flow to the heart muscle. It is generally preferred over other heart rate-lowering drugs due to its lower risk of side effects.
Corlanoris the brand name
Corlanor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corlanor
Ivabradine
2015
4
Approved as Treatment by the FDA
Ivabradine, also known as Corlanor, is approved by the FDA for 1 uses which include Left Ventricular Dysfunction .Left Ventricular Dysfunction
Helps manage Left Ventricular Dysfunction
Effectiveness
How Corlanor Affects PatientsIvabradine works by opening a type of channel (If) during the heart's resting phase and closing it during the active phase, so the effects of ivabradine are based on the heart rate. It will lower the heart rate in a linear, dose-dependent way, meaning that higher doses result in a greater effect. The maximum effective dose is 30-40mg and taking a higher dose will not cause serious sinus bradycardia. Additionally, the metabolite of ivabradine also helps to lower heart rate, contributing to its overall effect.
How Corlanor works in the bodyIvabradine works by slowing down the heart rate through a process called diastolic depolarization. It does this by blocking a type of ion channel called "funny channels" in the heart. This doesn't affect any of the other ion channels in the heart, and it works by attaching to the channel pore from the inside of the cell. By doing this, ivabradine disrupts the flow of ions, which in turn slows down the pacemaker activity in the sinoatrial node, reducing the heart rate and decreasing the demand for oxygen in the heart muscle. As a result, people taking ivab
When to interrupt dosage
The proposed dosage of Corlanor is contingent on the detected disorder, for example Chronic Stable Angina Pectoris, chronic, stable, symptomatic Heart Failure and Congestive Heart Failure. The measure of dosage is also governed by the technique of delivery (e.g. Tablet, film coated or Tablet, film coated - Oral) indicated in the table below.Condition
Dosage
Administration
Chronic Stable Angina Pectoris
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
chronic, stable, symptomatic Heart Failure
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Congestive Heart Failure
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Systolic Dysfunction
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Coronary Artery Disease (CAD)
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Pharmacotherapy
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Left Ventricular Dysfunction
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Cardiomyopathy, Dilated
, 5.0 mg, 5.0 mg/mL, 7.5 mg
Tablet, film coated, Tablet, film coated - Oral, Tablet, , Solution - Oral, Oral, Solution, Tablet - Oral
Warnings
Corlanor ContraindicationsCondition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
Pacemaker Dependence
Do Not Combine
Toxoplasma Infections
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
blood pressure less than 90/50 mmHg
Do Not Combine
Sinoatrial Block
Do Not Combine
third degree AV block
Do Not Combine
Acute Decompensated Heart Failure (ADHF)
Do Not Combine
heart rate
Do Not Combine
Common Corlanor Drug Interactions
Drug Name
Risk Level
Description
Deutetrabenazine
Major
The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Deutetrabenazine.
Flupentixol
Major
The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Flupentixol.
Glasdegib
Major
The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Glasdegib.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Hydroxyzine.
Ivosidenib
Major
The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Ivosidenib.
Corlanor Toxicity & Overdose RiskTaking ivabradine while pregnant could be toxic to the unborn baby and cause birth defects. Animal studies have found that ivabradine can be harmful to a developing fetus. Women should use effective contraception while taking this drug.
Corlanor Novel Uses: Which Conditions Have a Clinical Trial Featuring Corlanor?
20 active clinical trials are investigating the potential of Corlanor for alleviating chronic, stable, symptomatic Heart Failure, Cardiomyopathy, Dilated and Systolic Dysfunction.Condition
Clinical Trials
Trial Phases
chronic, stable, symptomatic Heart Failure
0 Actively Recruiting
Cardiomyopathy, Dilated
1 Actively Recruiting
Not Applicable
Systolic Dysfunction
1 Actively Recruiting
Phase 1, Phase 2
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Left Ventricular Dysfunction
8 Actively Recruiting
Not Applicable, Phase 4
Pharmacotherapy
0 Actively Recruiting
Chronic Stable Angina Pectoris
3 Actively Recruiting
Phase 3, Not Applicable
Congestive Heart Failure
8 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Corlanor Reviews: What are patients saying about Corlanor?
5Patient Review
5/7/2019 I had to change my medication regimen because Cardizem and Metoprolol weren't working for me. I'm now on a combo of Metoprolol and Corlanor, and after using it for four months, I haven't had any side effects and my tachycardia is completely gone. My average heart rate, which used to be 140-180 bpm, is now controlled and I'm able to enjoy an active lifestyle without fatigue, shortness of breath, or palpitations! Twice-daily doses for the rest of my life are totally worth it to me!
5Patient Review
3/1/2020 Before taking Corlanor, I had difficulty completing even light exercises. My heart would race up to 160/170 beats per minute (bpm) when walking short distances and I constantly felt fatigued due to the high heart rate. However, after taking Corlanor, I can exercise normally without worrying about having to rest all the time. Additionally, my resting heart rate is now around 60 bpm as opposed to the high 90s/100s bpm it was before starting this medication.
5Patient Review
4/16/2021 I finally found a doctor who would accurately treat my condition with Corlanor. It's been a great relief, but the drug is very expensive and not covered by insurance or manufacturer discount. In Canada, there is a generic version available, but we cannot legally order it from the U.S.
5Patient Review
11/3/2021 I've only been on this medication for a month, but I've already noticed significant changes. My heart rate used to spike just from standing up or taking a walk, but now it's much more stable. I am tired and have had some trouble breathing, but I'm hoping these side effects will lessen in time.
5Patient Review
6/4/2016 This treatment has been vital in keeping my heart condition under control. It's helped me immensely and I'm very grateful to my cardiologist for prescribing it.
5Patient Review
8/17/2018 This medication was a true lifesaver. Before I started taking it, I was constantly dizzy and passing out. Now, I'm able to work full-time and even go shopping without any problems.
4.7Patient Review
4/5/2018 I felt great for the first month after starting this medication, but then started feeling bad again. I'm not sure what's causing that now, but I still like the drug and will continue using it.
4.3Patient Review
10/31/2015 This medication has been very helpful overall, even though it does drop my heart rate into the 40s. I do sometimes feel dizzy, but that is a small price to pay for avoiding hospitalization.
4Patient Review
8/22/2016 I have experienced some negative side effects since starting this medication, including dizziness, weakness, and headaches. Additionally, it seems to be slowing my heart rate down, which I'm not sure is something I can tolerate long-term.
Patient Q&A Section about corlanor
What is the drug Corlanor used for?
"Corlanor lowers the heart rate for people with chronic heart failure." - Anonymous Online Contributor
Unverified Answer
What does Corlanor do for the heart?
"Corlanor is a medication that is used to slow down the heart rate by affecting the electrical activity of the heart. It is used in adults with chronic heart failure, in order to lower the risk of being hospitalized when symptoms worsen." - Anonymous Online Contributor
Unverified Answer
What are the side effects of Corlanor?
"The following side effects have been reported by adults during Corlanor's post-approval use: fainting, low blood pressure, a type of irregular heart beat called torsade de pointes, sudden uncontrolled whole-body shaking (ventricular fibrillation), a fast heart rate (ventricular tachycardia), swelling under the skin (angioedema), redness of the skin (erythema), rash, itching (pruritus), hives (urticaria), dizziness (vertigo), and double vision (diplopia), as well as visual impairment." - Anonymous Online Contributor
Unverified Answer
What type of drug is Corlanor?
"Corlanor is a class of hyperpolarization-activated cyclic nucleotide-gated channel blockers that was FDA-approved in 2015. It helps to slow the heart rate, and has less effect on lowering blood pressure than other medications designed for the same purpose such as beta blockers." - Anonymous Online Contributor
Unverified Answer