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What is Colestipol Hydrochloride
ColestipolThe Generic name of this drug
Treatment SummaryColestipol is a medication used to lower cholesterol levels and reduce the risk of atherosclerotic vascular disease due to hypercholesterolemia. It is usually used as an adjunct therapy, as it works by reducing the absorption of bile acids and fats in the gut. It is not suitable for people with constipation, biliary obstruction, or who take complex medication regimens. Colestipol has few side effects as it does not enter the bloodstream and is generally well-tolerated.
Colestipol Hydrochlorideis the brand name
Colestipol Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Colestipol Hydrochloride
Colestipol
1977
18
Approved as Treatment by the FDA
Colestipol, also known as Colestipol Hydrochloride, is approved by the FDA for 2 uses like Primary Hypercholesterolemia and Diet .Primary Hypercholesterolemia
Used in combination with other therapies
Diet
Used in combination with other therapies
Effectiveness
How Colestipol Hydrochloride Affects PatientsCholesterol is the main, and possibly the only, ingredient needed to make bile acids. During digestion, these bile acids are released in the intestines to break down fat and lipids, allowing them to be absorbed. Most of the bile acids are absorbed back into the body, but a small amount is left in the blood. Colestipol hydrochloride binds to the bile acids present in the intestines, preventing them from being reabsorbed by the body. The chloride in the drug is replaced by other anions, which have a stronger attraction to the drug than chloride ions.
How Colestipol Hydrochloride works in the bodyColestipol is a medicine that helps reduce cholesterol levels. It works by preventing bile acids from being reabsorbed by the body. This leads to increased breakdown of cholesterol, which then increases the number of low-density lipoprotein (LDL) receptors in the liver. This allows the LDL to be taken up more easily, reducing cholesterol levels in the blood. The liver also produces more cholesterol, but this does not affect the serum cholesterol levels.
When to interrupt dosage
The advised dosage of Colestipol Hydrochloride is contingent upon the determined affliction. The quantity of dosage likewise shifts, as per the method of delivery (e.g. Granule - Oral or Granule, for suspension) listed in the table beneath.Condition
Dosage
Administration
Primary Hypercholesterolemia
, 1000.0 mg, 5000.0 mg, 5.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral
Diet
, 1000.0 mg, 5000.0 mg, 5.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Granule, Granule - Oral, Suspension, Suspension - Oral, Granule, for suspension, Granule, for suspension - Oral
Warnings
Colestipol Hydrochloride ContraindicationsCondition
Risk Level
Notes
complete biliary obstruction
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Colestipol may interact with Pulse Frequency
Common Colestipol Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Mycophenolate mofetil
Major
Colestipol can cause a decrease in the absorption of Mycophenolate mofetil resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mycophenolic acid
Major
Colestipol can cause a decrease in the absorption of Mycophenolic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raloxifene
Major
Colestipol can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
(R)-warfarin
Minor
Colestipol can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
(S)-Warfarin
Minor
Colestipol can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colestipol Hydrochloride Toxicity & Overdose RiskThere have been no reports of colestipol overdosing, but it can cause blockages in the digestive tract. Colestipol has not been tested in pregnant or breastfeeding women, and there is no data on how it affects fertility in humans. The safety of using colestipol tablets in children under 18 years of age has not been established. Elderly people may be more likely to experience gastrointestinal side effects and nutritional problems. The lowest toxic dose of colestipol in rats is greater than 1000mg/kg.
Colestipol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Colestipol Hydrochloride?
Twelve active clinical trials are currently assessing the utility of Colestipol Hydrochloride to alleviate Primary Hypercholesterolemia.Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Diet
5 Actively Recruiting
Not Applicable
Colestipol Hydrochloride Reviews: What are patients saying about Colestipol Hydrochloride?
5Patient Review
6/27/2020 If you're struggling to swallow this large pill, I recommend mixing it with a teaspoon of applesauce. It really does the trick!
4.7Patient Review
3/27/2022 This treatment is excellent. It's helped me a lot and I'm very grateful for it.
2.3Patient Review
5/16/2017 I have very loose stool and must be close to a bathroom at all times in the morning, which limits my mobility. I also have to be careful of passing gas. I'm going to ask my doctor to find something else, as statins are not an option for me.
1Patient Review
1/7/2016 I experienced stomach pain and cramps a few hours after taking this medication.
Patient Q&A Section about colestipol hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking colestipol?
"These side effects may occur: constipation, stomach/abdominal pain, gas, nausea, and vomiting. If you experience any of these effects, tell your doctor or pharmacist. To help prevent constipation, eat a diet high in fiber, drink plenty of water, and exercise."
Answered by AI
Is colestipol good for IBS?
"The text states that colestipol treatment improved IBS symptoms and that increased colonic bile acid exposure influences bowel habit and colonic transit time in patients with IBS."
Answered by AI
Is colestipol used for diarrhea?
"Colestipol is a medication that can be prescribed by doctors to help treat diarrhea caused by an excess of bile acids. Possible side effects of colestipol include constipation, burping, nausea, vomiting, flatulence, diarrhea, anxiety, or fatigue."
Answered by AI
What is colestipol hydrochloride used for?
"Colestipol is a medication used to lower high cholesterol levels in the blood. This medication works by attaching to certain substances in the intestine, which help to prevent medical problems caused by cholesterol clogging the blood vessels."
Answered by AI