Clorazepate Dipotassium

Generalized Anxiety Disorder, Seizures, Acute Alcohol Withdrawal + 1 more
Treatment
4 FDA approvals
20 Active Studies for Clorazepate Dipotassium

What is Clorazepate Dipotassium

Clorazepic acidThe Generic name of this drug
Treatment SummaryChlordiazepoxide is a medication used to treat anxiety, muscle spasms, and seizures. It is a type of benzodiazepine that is soluble in water, making it easy for the body to absorb.
Tranxene T-Tabis the brand name
image of different drug pills on a surface
Clorazepate Dipotassium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tranxene T-Tab
Clorazepic acid
1972
55

Approved as Treatment by the FDA

Clorazepic acid, otherwise called Tranxene T-Tab, is approved by the FDA for 4 uses which include Generalized Anxiety Disorder and Seizures .
Generalized Anxiety Disorder
Helps manage Generalized Anxiety Disorder
Seizures
Anxiety
Acute Alcohol Withdrawal

Effectiveness

How Clorazepate Dipotassium Affects PatientsClorazepate belongs to a class of drugs called benzodiazepines that have a calming effect on the central nervous system. It is quickly broken down in the body to form the metabolite nordiazepam that has a sedative effect. Studies have shown that clorazepate affects the central nervous system in a similar way to other benzodiazepines. Since it is quickly changed into nordiazepam, there is very little of the drug left in the body.
How Clorazepate Dipotassium works in the bodyBenzodiazepines bind to receptors in the brain, which control sleep, muscle relaxation, anticonvulsant activity, motor coordination, and memory. This binding helps the neurotransmitter GABA to work better, which relaxes the body. GABA connects to chloride channels and helps to stop the brain from becoming too excited.

When to interrupt dosage

The proposed dosage of Clorazepate Dipotassium is subject to the recognized condition, such as Seizures, Anxiety and Generalized Anxiety Disorder. The measure of dosage can be located in the table beneath, contingent upon the approach of administration (e.g. Tablet - Oral or Capsule - Oral).
Condition
Dosage
Administration
Anxiety
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Acute Alcohol Withdrawal
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Generalized Anxiety Disorder
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Seizures
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Clorazepate Dipotassium has one contraindication and should not be combined with the conditions found in the following table.Clorazepate Dipotassium Contraindications
Condition
Risk Level
Notes
Glaucoma
Do Not Combine
There are 20 known major drug interactions with Clorazepate Dipotassium.
Common Clorazepate Dipotassium Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Clorazepic acid is combined with Oliceridine.
Sodium oxybate
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Clorazepate Dipotassium Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 1320 mg/kg. Monkeys have a higher tolerance, with the lowest toxic dose exceeding 1600 mg/kg. Overdosing on the drug can cause confusion, unconsciousness, poor coordination, drowsiness, and slower reaction times.
image of a doctor in a lab doing drug, clinical research

Clorazepate Dipotassium Novel Uses: Which Conditions Have a Clinical Trial Featuring Clorazepate Dipotassium?

Currently, 32 active clinical trials are assessing the potential of Clorazepate Dipotassium to reduce Acute Alcohol Withdrawal Symptoms, Anxiety and Seizure Frequency.
Condition
Clinical Trials
Trial Phases
Anxiety
0 Actively Recruiting
Seizures
2 Actively Recruiting
Phase 3
Acute Alcohol Withdrawal
0 Actively Recruiting
Generalized Anxiety Disorder
33 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4

Clorazepate Dipotassium Reviews: What are patients saying about Clorazepate Dipotassium?

5Patient Review
9/17/2011
Clorazepate Dipotassium for Anxious
I've been taking this medication for decades and it's really helped me to feel calmer and more level-headed.
5Patient Review
7/13/2016
Clorazepate Dipotassium for Anxious
I take this drug for my anxiety, which I have due to a combination of circumstances and genetics. The recommended dosage is twice per day, but I've found that once per day works just as well for me now that my condition has improved. It's also non-drowsy and non-vertigo-inducing, which is great.
5Patient Review
2/2/2010
Clorazepate Dipotassium for Anxious
I felt lightheaded and relaxed, but sometimes I would get rushes of panic. A few deep breaths always helped me calm down again, though.
5Patient Review
5/16/2013
Clorazepate Dipotassium for Anxious
Though it wasn't as effective as other treatments I've tried, this still helped take the edge off my anxiety. I don't take any benzodiazepines anymore, but I am taking gabapentin instead which doesn't have as many negative side effects.
5Patient Review
3/24/2009
Clorazepate Dipotassium for Anxious
5Patient Review
9/14/2021
Clorazepate Dipotassium for Epileptic Seizure
I'm constantly amazed by how well benzodiazepines work in preventing seizures and calming my aura. They really help me feel normal again when stress and anxiety get to be too much.
5Patient Review
6/4/2011
Clorazepate Dipotassium for Anxious
I had hallucinations when I took the 7.5mg dose at night, so I would recommend taking this medicine in the morning and evening instead.
5Patient Review
1/21/2016
Clorazepate Dipotassium for Anxious
This medication does a great job at relieving anxiety.
4.7Patient Review
10/16/2015
Clorazepate Dipotassium for Anxious
I became really depressed after taking this medication.
4.3Patient Review
6/18/2009
Clorazepate Dipotassium for Anxious
4Patient Review
10/9/2009
Clorazepate Dipotassium for Anxious
4Patient Review
9/23/2010
Clorazepate Dipotassium for Anxious
This medication has been great for me, but after taking it for a few years, I have noticed that it's not working as well as it used to.
3.7Patient Review
2/15/2013
Clorazepate Dipotassium for Epileptic Seizure
This drug has been effective in quelling my anxiety in a variety of situations.
3.7Patient Review
1/19/2013
Clorazepate Dipotassium for Anxious
This drug didn't do much for my anxiety.
3.7Patient Review
4/1/2016
Clorazepate Dipotassium for Anxious
I experienced fatigue, dry mouth, trouble walking, insomnia, and stiffness in my muscles and joints while taking this medication.
3.3Patient Review
10/10/2010
Clorazepate Dipotassium for Anxious
This drug has been a life-saver for me. It helps to keep my vertigo under control so that I can live a normal life. Recently, I tried reducing my dosage and within just a few days, I started feeling dizzy again. This medication is essential for me in order to function normally – without it, I suffer from violent spinning, nausea, hearing loss, and difficulty walking.
1Patient Review
6/19/2012
Clorazepate Dipotassium for Anxious
Clorazepate was prescribed to me after having frequent anxiety attacks and not sleeping well at night. I take one in the morning and one before bedtime. It removes the uncomfortable symptoms without putting my head in a fog or any noticeable other symptoms. I do wish, though, that it would help with tremors in my hands when I'm nervous. Doesn't really help that much.
1Patient Review
1/8/2014
Clorazepate Dipotassium for Anxious
I've been using this medication for over 10 years. I used to be really nervous and worried all the time, but this pill has helped me a lot. It takes the edge off of things and makes me feel more relaxed.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about clorazepate dipotassium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clorazepate dipotassium a narcotic?

"TRANXENE is federally controlled because it can be abused or lead to dependence."

Answered by AI

Can you get high from clorazepate?

"Clorazepate is frequently abused with other drugs, such as alcohol, in order to enhance the high.

As with other drugs in its class, people abuse clorazepate because it has sedative effects which can produce a 'high'. Clorazepate is often used alongside other substances, such as alcohol, to heighten this feeling."

Answered by AI

Is clorazepate dipotassium a benzo?

"Clorazepate dipotassium is a type of benzodiazepine. Taking benzodiazepines with opioid medicines, alcohol, other central nervous system depressants, or street drugs can cause severe drowsiness, breathing problems, coma, and death."

Answered by AI

What is clorazepate dipotassium used for?

"This medication is used to treat anxiety, acute alcohol withdrawal, and seizures. It works by enhancing the effects of a certain natural chemical in the body (GABA)."

Answered by AI

Clinical Trials for Clorazepate Dipotassium

Have you considered Clorazepate Dipotassium clinical trials? We made a collection of clinical trials featuring Clorazepate Dipotassium, we think they might fit your search criteria.
Have you considered Clorazepate Dipotassium clinical trials? We made a collection of clinical trials featuring Clorazepate Dipotassium, we think they might fit your search criteria.
Have you considered Clorazepate Dipotassium clinical trials? We made a collection of clinical trials featuring Clorazepate Dipotassium, we think they might fit your search criteria.