Clarithromycin

Bartonellosis, Acute maxillary sinusitis, Pertussis + 14 more

Treatment

12 FDA approvals

20 Active Studies for Clarithromycin

Treatment for

Bartonellosis

What is Clarithromycin

ClarithromycinThe Generic name of this drug

Treatment SummaryClarithromycin is an antibiotic derived from erythromycin. It works by inhibiting the production of proteins in bacteria, which prevents them from multiplying. Depending on the concentration of the drug, it can either stop the bacteria from growing or kill them.

Biaxinis the brand name

image of different drug pills on a surface

Clarithromycin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Biaxin

Clarithromycin

1991

187

Approved as Treatment by the FDA

Clarithromycin, also known as Biaxin, is approved by the FDA for 12 uses which include Otitis Media (OM) and Urinary Tract Infection (UTI) .

Otitis Media (OM)

Urinary Tract Infection (UTI)

Community Acquired Pneumonia (CAP)

Mycobacterial Infections

HIV

Bacterial Infections

Acute maxillary sinusitis

Duodenal Ulcer

Used to treat Duodenal ulcer caused by helicobacter pylori in combination with Amoxicillin

Mycobacterium Infections

Streptococcal Pharyngitis

Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB)

Tonsillitis

Effectiveness

How Clarithromycin Affects PatientsClarithromycin is a type of antibiotic used to treat a range of bacteria, including many common types such as Staphylococcus aureus, Haemophilus influenzae, Mycoplasma, and Chlamydia. It has been found to be as effective or more effective than erythromycin against certain bacteria. Clarithromycin usually stops bacteria from reproducing, but can sometimes kill them.

How Clarithromycin works in the bodyClarithromycin works by entering bacteria cells and binding to a part of their ribosomes, which are responsible for making proteins. This binding blocks the bacteria's ability to make proteins, preventing it from reproducing and causing infection. Clarithromycin also stops enzymes that break down medicine in the liver, making it more effective.

When to interrupt dosage

The recommended dosage of Clarithromycin is contingent upon the determined condition, for instance Mycobacterium Infections, Lyme Disease and Bacterial Infections. The amount may vary as per the administration technique (e.g. Powder, for suspension or Capsule; Kit; Tablet) featured in the table below.

Condition

Dosage

Administration

Streptococcal Pharyngitis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Bacterial Infections

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Lyme Disease

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Community Acquired Pneumonia (CAP)

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Urinary Tract Infection (UTI)

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

HIV

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Otitis Media (OM)

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Bartonellosis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Acute maxillary sinusitis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Pertussis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Tonsillitis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Mycobacterium Infections

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Bacterial Endocarditis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Duodenal Ulcer

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB)

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Bacterial Endocarditis

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Mycobacterial Infections

, 500.0 mg, 250.0 mg, 250.0 mg/mL, 125.0 mg/mL, 1000.0 mg

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Kit - Oral

Warnings

Clarithromycin Contraindications

Condition

Risk Level

Notes

Liver Dysfunction

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

cholestatic jaundice

Do Not Combine

There are 20 known major drug interactions with Clarithromycin.

Common Clarithromycin Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Clarithromycin.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Clarithromycin.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Clarithromycin.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Clarithromycin.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Clarithromycin.

Clarithromycin Toxicity & Overdose RiskSymptoms of clarithromycin toxicity include diarrhea, nausea, bad taste, indigestion, stomach pain, and temporary hearing loss. In some cases, colitis, allergic reactions (from hives to anaphylaxis), liver damage, and tooth discoloration have been reported. Animal studies have also linked clarithromycin to fetal abnormalities such as heart defects, cleft palate and slow growth. Additionally, this drug may cause a prolonged QT interval.

image of a doctor in a lab doing drug, clinical research

Clarithromycin Novel Uses: Which Conditions Have a Clinical Trial Featuring Clarithromycin?

160 active clinical trials are currently exploring the potential of Clarithromycin to provide relief for Pertussis, HIV and Urinary Tract Infection (UTI).

Condition

Clinical Trials

Trial Phases

HIV

146 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Pertussis

1 Actively Recruiting

Phase 1

Tonsillitis

0 Actively Recruiting

Bacterial Endocarditis

2 Actively Recruiting

Not Applicable

Bartonellosis

0 Actively Recruiting

Bacterial Endocarditis

0 Actively Recruiting

Urinary Tract Infection (UTI)

24 Actively Recruiting

Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable

Otitis Media (OM)

0 Actively Recruiting

Acute maxillary sinusitis

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB)

0 Actively Recruiting

Streptococcal Pharyngitis

1 Actively Recruiting

Not Applicable

Community Acquired Pneumonia (CAP)

1 Actively Recruiting

Not Applicable

Lyme Disease

8 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable

Mycobacterium Infections

0 Actively Recruiting

Mycobacterial Infections

0 Actively Recruiting

Clarithromycin Reviews: What are patients saying about Clarithromycin?

4.7Patient Review

7/25/2022

Clarithromycin for infection caused by bacteria

I was in a lot of pain from an untreated bacterial infection, and these tablets were worth their weight in gold to me. I don't care about the side effects; they made me better. If you're bothered about the side effects, then you must not have been in as much pain as I was. Get a life—thank goodness you're alive and these tablets made you better instead of complaining about the side effects!

3.3Patient Review

7/19/2022

Clarithromycin for Acute Infection of the Nose, Throat or Sinus

I got tonsillitis, then my doctor recommended this Clarithromycine antibiotic. On the first day, the pain in my tonsils lessened. However, I didn't like its side effect; whenever I ate and took the medicine, I felt stomach pain and vomitied every two hours.

2.3Patient Review

7/3/2022

Clarithromycin for Infection of the Middle Ear caused by Streptococcus

After only three days of taking this antibiotic, I experienced a range of awful side effects, including but not limited to: jitters, watery diarrhea, nausea, fatigue, headache and brain fog. Never have I felt this bad before; I had to stop taking the medication and will never take it again. It's unbelievable that this is on the market.

2.3Patient Review

6/15/2022

Clarithromycin for Middle Ear Infection

I was given this medication because of an ear infection after having the flu. On the first day, I had severe stomach pain for around 20 minutes. However, what really bothered me from the second day onward was the bitter taste in my mouth that didn't go away for more than 8 hours after taking the medication. Today is my third day, and the bitter saliva is still bothering me.

2.3Patient Review

10/11/2022

Clarithromycin for infection caused by bacteria

I found the recommended dosage of this drug to be far too much for my system. I had severe reactions including joint and muscle pain, nausea, and insomnia. If you've ever had a reaction to antibiotics in the past, I would recommend avoiding this medication entirely.

2.3Patient Review

4/16/2022

Clarithromycin for Acute Infection of the Nose, Throat or Sinus

I never want to take this again. It sent my anxiety levels through the roof and I would rather be in pain than deal with the side effects.

1.3Patient Review

1/9/2022

Clarithromycin for Acute Maxillary Sinus H. Influenzae Bacteria Infection

I unfortunately experienced a range of adverse effects from taking this medication. I would advise against it based on my personal experience.

1.3Patient Review

4/25/2022

Clarithromycin for Middle Ear Infection

The side effects of Klacid were so bad that I couldn't even finish the course of antibiotics. I experienced insomnia, restlessness, and awful abdominal cramps and nausea. I would never use this medication again.

1Patient Review

11/10/2022

Clarithromycin for infection caused by bacteria

I had some nasty side effects after only taking this twice. I wouldn't recommend it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about clarithromycin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clarithromycin stronger than amoxicillin?

"Clarithromycin seems to work as well as amoxicillin/clavulanate against acute maxillary sinusitis, and it may cause fewer problems with upset stomach."

Answered by AI

What are the most common side effects of clarithromycin?

"Some potential side effects of this medication include diarrhea, nausea, vomiting, stomach pain, heartburn, gas, a change in taste, and headache."

Answered by AI

Is clarithromycin and amoxicillin the same?

"This product contains two different types of antibiotics: amoxicillin, which is a penicillin-type antibiotic, and clarithromycin, which is a macrolide-type antibiotic. These antibiotics work by stopping the growth of bacteria, and they are effective against only bacterial infections."

Answered by AI

What is clarithromycin antibiotic used for?

"This drug is used to treat bacterial infections by killing the bacteria. It is also used in tandem with other drugs to treat ulcers in the duodenum, which are caused by the bacteria H. pylori. Additionally, this medication is taken to prevent and treat infection by the Mycobacterium avium complex."

Answered by AI

Clinical Trials for Clarithromycin

Image of Alabama CRS in Birmingham, United States.

16055 NFL Delta Gly4 Env Protein Trimer +2 More for HIV/AIDS

This trial aims to test two different vaccines in adults without HIV to see if they are safe and well-tolerated. The study will also explore whether the vaccines can help in the development of B-cell

Alabama CRS (+5 Sites)

Image of Center for AIDS Intervention Research, Medical College of Wisconsin in Milwaukee, United States.

Supportive-Expressive Peer Social Support Group Intervention +1 More for HIV/AIDS

This trial aims to test two interventions, peer social support groups and case management, to see if they can help improve health outcomes and quality of life for older people living with HIV in rural areas of the

Center for AIDS Intervention Research, Medical College of WisconsinJennifer Walsh, PhD

Image of Alabama CRS (Site ID: 31788) in Birmingham, United States.

CD4BS CH505M5 Pr-NP1 for HIV/AIDS

This trial is testing two HIV vaccines with adjuvants to see if they can help people develop an immune response against the virus that causes AIDS. It involves 42 participants at multiple sites in the

Waitlist Available

Alabama CRS (Site ID: 31788) (+2 Sites)

Image of University of Maryland, Baltimore in Baltimore, United States.

Behavioral Activation, Nutrition, and Activity Intervention for HIV/AIDS

"This trial will investigate if a program to help people over 50 with HIV is feasible. The program involves a coach who will motivate participants to be more active, reduce loneliness, and eat healthier."

Waitlist Available

University of Maryland, BaltimoreAnn Gruber-Baldini, PhD

Have you considered Clarithromycin clinical trials? We made a collection of clinical trials featuring Clarithromycin, we think they might fit your search criteria.

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Oral care treatment as usual for Oral Bacterial Infection

This trial is going to compare the effectiveness of two different oral care treatments in patients who have a tube in their throat. The goal of the trial is to see which treatment can reduce the amount of bacteria

Waitlist Available

Cleveland Clinic FoundationMarcelo Gama de Abreu, MD

Image of University of Arkansas for Medical Sciences in Little Rock, United States.

Universal Basic Income for Health Care Utilization

Little Rock, AR

This trial aims to study the effects of providing a Universal Basic Income (UBI) to Black men living with HIV in Arkansas. The goal is to understand if giving these men a monthly cash transfer of

University of Arkansas for Medical SciencesAshley Williams, MHS

Image of University of Central Florida in Orlando, United States.

CTI-MLP assessment for HIV/AIDS

This trial seeks to understand how legal aid affects the HIV care of formerly incarcerated individuals, as well as the effectiveness of training providers in communication and medical legal partnerships.

University of Central Florida

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Dyadic Case Management for Case Management

This trial will test whether case management can help people living with HIV/on PrEP improve financial wellbeing, access food, and stay linked to care for better viral suppression.

University of ChicagoJohn Schneider, MD

Have you considered Clarithromycin clinical trials? We made a collection of clinical trials featuring Clarithromycin, we think they might fit your search criteria.

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Peer Navigator Training for HIV Prevention in Hispanic/Latino Men

Winston-Salem, NC

This trial aims to reduce HIV infection in Hispanic/Latino men who have sex with men. We must address disparities among vulnerable groups.

Waitlist Available

Wake Forest University Health SciencesScott D Rhodes, PhD

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HIV Prevention for Latino Male Couples

This trial will test an intervention to increase use of HIV protection in Latinx couples.

University of Central Florida

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Cervical Cancer Screen-and-Treat Strategies for Cervical Cancer

This trial aims to increase cervical cancer screening & treatment for women living with HIV in Nigeria, improving health & life expectancy.

UC San DiegoGregory Aarons, PhD

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Probiotic + Prebiotic for Fatty Liver in HIV/AIDS

This trial will explore if changes in the gut microbiome are linked to fatty liver in people with HIV and if probiotics & fiber can help improve it.

Waitlist Available

Vanderbilt University Medical Center

Have you considered Clarithromycin clinical trials? We made a collection of clinical trials featuring Clarithromycin, we think they might fit your search criteria.

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