Cimetidine

Zollinger-Ellison Syndrome, Indigestion, Heartburn + 11 more
Treatment
7 FDA approvals
20 Active Studies for Cimetidine

What is Cimetidine

CimetidineThe Generic name of this drug
Treatment SummaryCimetidine is a drug that blocks histamine from binding to histamine H2 receptors and reduces the production of stomach acid. It can also inhibit the activity of enzymes to help prevent the growth of some types of cancer cells. Cimetidine is commonly used to treat conditions such as ulcers and acid reflux, and is sometimes used in neoadjuvant therapy.
Cimetidineis the brand name
image of different drug pills on a surface
Cimetidine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cimetidine
Cimetidine
1994
91

Approved as Treatment by the FDA

Cimetidine, also known as Cimetidine, is approved by the FDA for 7 uses which include Adenoma and Heartburn .
Adenoma
Helps manage multiple endocrine adenomas
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)
Systemic Mastocytosis
Helps manage Systemic Mastocytosis
Gastric ulcer
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Duodenal Ulcer
Gastric hypersecretion
Helps manage Gastric hypersecretion

Effectiveness

How Cimetidine Affects PatientsCimetidine works by blocking histamine receptors in the stomach, reducing the amount of stomach acid that is produced. It is used to treat stomach and intestinal ulcers, heartburn, and other digestive issues. It also affects the way certain enzymes in the liver work, and can increase the number of bacteria in the stomach.
How Cimetidine works in the bodyCimetidine works by blocking the histamine receptor on the cells in the stomach. This prevents histamine from having an effect and reduces the production of acid. This leads to a decrease in stomach acid and volume.

When to interrupt dosage

The proposed portion of Cimetidine is based on the diagnosed condition, such as Acid indigestion, Cystic Fibrosis (CF) and Systemic Mastocytosis. The amount of dosage differs, as per the technique of delivery (e.g. Liquid or Intramuscular; Intravenous) specified in the table below.
Condition
Dosage
Administration
Cystic Fibrosis (CF)
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Heartburn
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Zollinger-Ellison Syndrome
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
NSAID use
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Duodenal Ulcer
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Systemic Mastocytosis
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Indigestion
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Gastrointestinal Symptoms
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Adenoma
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Gastric ulcer
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Heartburn
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
develop NSAID-induced gastric ulcers
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Gastric hypersecretion
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Duodenum
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical

Warnings

Cimetidine Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Cimetidine may interact with Pulse Frequency
There are 20 known major drug interactions with Cimetidine.
Common Cimetidine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Cimetidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Cimetidine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Cimetidine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Cimetidine.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Cimetidine.
Cimetidine Toxicity & Overdose RiskIf someone overdoses on cimetidine, it is essential to keep their airway and cardiovascular system stable. The patient should be watched carefully and given treatment to relieve symptoms. If necessary, medical professionals may perform a gastric lavage or administer activated charcoal.
image of a doctor in a lab doing drug, clinical research

Cimetidine Novel Uses: Which Conditions Have a Clinical Trial Featuring Cimetidine?

27 active trials are currently assessing the potential of Cimetidine to combat Heartburn, Duodenal Ulcer and Duodenum-related conditions.
Condition
Clinical Trials
Trial Phases
develop NSAID-induced gastric ulcers
0 Actively Recruiting
Cystic Fibrosis (CF)
0 Actively Recruiting
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Gastric hypersecretion
0 Actively Recruiting
Gastric ulcer
0 Actively Recruiting
Systemic Mastocytosis
1 Actively Recruiting
Phase 1
NSAID use
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Indigestion
13 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 1, Phase 4
Adenoma
0 Actively Recruiting
Gastrointestinal Symptoms
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Duodenum
0 Actively Recruiting
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Duodenal Ulcer
0 Actively Recruiting

Cimetidine Reviews: What are patients saying about Cimetidine?

5Patient Review
12/30/2008
Cimetidine for Condition in which Stomach Acid is Pushed Into the Esophagus
I've been using this to treat a plantar wart and so far it's going great. I have noticed that my big toe, which is arthritis has been hurting more than normal; and my hips have been bothering me especially when sleeping. I read an article about such medications (regular OTC) that cause hip pain, wondering if this is the cause of mine. I've been to PT without relief.
5Patient Review
7/10/2010
Cimetidine for Heartburn
I have had acid reflux for a long time and tried this medication. It unfortunately did not help subside the acid nor allow me to sleep. On top of that, it made my heart rate spike which was extremely uncomfortable.
5Patient Review
10/1/2013
Cimetidine for Excessive Production of Stomach Acid
This medication has been great for treating my excess stomach acid and hand warts. I've only been using it for a short time, but already the warts are smaller and the heartburn is gone.
5Patient Review
7/12/2008
Cimetidine for Condition in which Stomach Acid is Pushed Into the Esophagus
5Patient Review
12/9/2008
Cimetidine for Condition in which Stomach Acid is Pushed Into the Esophagus
I have found this medication to be effective with no side effects. I take 2 tablets a day 400mg. each.
4.7Patient Review
6/8/2018
Cimetidine for Bleeding from Stomach, Esophagus or Duodenum
I didn't notice any difference after taking this medication.
4Patient Review
4/25/2020
Cimetidine for Excessive Production of Stomach Acid
This medication has quickly and effectively resolved my heartburn issues. I no longer have to wake up in the middle of the night with a burning sensation, and I can finally eat without pain!
4Patient Review
5/17/2011
Cimetidine for Condition in which Stomach Acid is Pushed Into the Esophagus
I've been using this treatment for my pericarditis for three years now with great results. It's helped me manage the inflammation and pain associated with the condition.
3.7Patient Review
6/29/2011
Cimetidine for Hives
I've been taking this medication for a few months now, and it's the best of all the ones I've tried (Zegerid, Prilosec, Nexium, Famotidine). It lasts for about four to five hours after I take it at night. In addition to the pill, I also use a raised pillow, eat early in the evening, and watch my diet.
3.7Patient Review
10/27/2015
Cimetidine for Condition in which Stomach Acid is Pushed Into the Esophagus
I've been taking this once a day at bedtime for two years now, as recommended by my doctor. It has worked well to reduce the acid in my stomach, but I have noted some negative side effects like tingling and numbness in my feet and significant erectile dysfunction. Otherwise, it's a decent medication.
3.7Patient Review
9/29/2020
Cimetidine for Heartburn
Cimetidine helps with my heartburn, but I still get reflux at least once a week. Prilosec works better for me, but it's too expensive to keep buying.
3.3Patient Review
4/8/2009
Cimetidine for Stress Ulcer Prevention
I was prescribed 600mg of this medication for Acid Reflux a few years ago, but when I lost my insurance I couldn't afford it anymore. Luckily, I found these 200mg tablets at CVS and they've done the trick!
1Patient Review
3/3/2010
Cimetidine for Condition in which Stomach Acid is Pushed Into the Esophagus
I had been struggling with acid reflux for years, and it was really taking a toll on my nightly sleep. My doctor recommended that I try an over-the-counter medication called cimetidine, and it has completely cured my problem in just 9 months!
1Patient Review
9/2/2011
Cimetidine for Hives
My pediatrician prescribed this for my nephew's itchy rash, but he won't take it because it tastes so bad. I've tried many ways to get him to take it, but he won't even try it if he gets a whiff of the taste.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cimetidine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a cimetidine used for?

"Cimetidine is a medication that is used to treat ulcers, GERD, and other conditions where the stomach produces too much acid."

Answered by AI

What kind of drug is cimetidine?

"Cimetidine is a prescription medication designed to reduce acidity. It provides relief from heartburn associated with acid indigestion and sour stomach, and can also prevent heartburn from occurring in the first place by limiting exposure to triggering foods and beverages."

Answered by AI

Why was cimetidine taken off the market?

"The FDA has announced that several medicines may contain unsafe levels of N-Nitrosodimethylamine (NDMA), a substance that is classified as a "probable human carcinogen" by the World Health Organization."

Answered by AI

Is cimetidine the same as Zantac?

"Cimetidine and ranitidine are not the same medication, but they are similar. They are both in the same drug class and lower the amount of acid in your stomach. Ranitidine is no longer available in the United States, so cimetidine can be a good replacement option."

Answered by AI

Clinical Trials for Cimetidine

Have you considered Cimetidine clinical trials? We made a collection of clinical trials featuring Cimetidine, we think they might fit your search criteria.
Have you considered Cimetidine clinical trials? We made a collection of clinical trials featuring Cimetidine, we think they might fit your search criteria.
Have you considered Cimetidine clinical trials? We made a collection of clinical trials featuring Cimetidine, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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