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What is Cervidil
DinoprostoneThe Generic name of this drug
Treatment SummaryDinoprostone is a prescription drug used to prepare the cervix for labor and induce labor. It is a natural prostaglandin E2 that stimulates the production of certain hormones which help the cervix to soften and open up. It also helps to break down bone tissue, making it easier for the baby to pass through the birth canal.
Prostin E2is the brand name
Cervidil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prostin E2
Dinoprostone
1978
5
Effectiveness
How Cervidil Affects PatientsDinoprostone is the same as prostaglandin E2 (PGE2). It helps bring on labor and delivery by increasing muscle activity in the uterus, which causes the pregnancy to end. Dinoprostone can also cause increased muscle activity in the stomach and intestines, which can lead to vomiting and diarrhea.
How Cervidil works in the bodyDinoprostone helps empty the uterus by causing the muscles in the uterus to contract in a way similar to labor contractions. We don't know exactly how it works, but one possibility is that it influences calcium movement and a certain type of molecule in the cells. Dinoprostone also causes changes to the cervix, which may be linked to the breakdown of collagen.
When to interrupt dosage
The prescribed amount of Cervidil is contingent upon the diagnosed condition, including Uterine dilation and evacuation, Cervix Uteri and Labour. The measure of dosage is dependent on the administration technique featured in the following table.Condition
Dosage
Administration
Uterus evacuation
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Medically induced abortion
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Cervix Uteri
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Uterine dilation and evacuation
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Induction of Labour
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Gestational Trophoblastic Disease
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Labour
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
, Vaginal, Insert, Insert - Vaginal, Insert, extended release - Vaginal, Insert, extended release, Endocervical, Gel, Gel - Endocervical, Gel - Vaginal, Oral, Tablet, Tablet - Oral, Suppository, Suppository - Vaginal
Warnings
There are 20 known major drug interactions with Cervidil.Common Cervidil Drug Interactions
Drug Name
Risk Level
Description
Carbetocin
Major
The risk or severity of adverse effects can be increased when Dinoprostone is combined with Carbetocin.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Dinoprostone.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Dinoprostone.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Dinoprostone.
Dofetilide
Major
The serum concentration of Dofetilide can be increased when it is combined with Dinoprostone.
Cervidil Toxicity & Overdose RiskThe lowest toxic dose of this drug to mice is 750mg/kg, and 500mg/kg for rats.
Cervidil Novel Uses: Which Conditions Have a Clinical Trial Featuring Cervidil?
Currently, 3 active clinical trials are being conducted to evaluate the potential of Cervidil in providing relief for Cervix Uteri, Medically induced abortion and Uterine dilation and evacuation.Condition
Clinical Trials
Trial Phases
Cervix Uteri
0 Actively Recruiting
Uterus evacuation
0 Actively Recruiting
Labour
2 Actively Recruiting
Phase 4, Phase 3
Gestational Trophoblastic Disease
2 Actively Recruiting
Phase 2, Not Applicable
Induction of Labour
0 Actively Recruiting
Medically induced abortion
1 Actively Recruiting
Not Applicable
Uterine dilation and evacuation
0 Actively Recruiting
Cervidil Reviews: What are patients saying about Cervidil?
5Patient Review
2/21/2017 Though it was uncomfortable, this medication did exactly what it was supposed to. I had to use it twice, unfortunately.
3.7Patient Review
1/9/2010 While this treatment did help me go into labor, it was incredibly intense and honestly quite scary. My contractions peaked and I ended up having to have an emergency c-section because my placenta split in half.
2.7Patient Review
4/5/2019 This should not be prescribed lightly! Having it put in place was the most excruciating pain I have ever felt, topping my child's birth. It was extra pain, stress, and crying than was justifiable just to speed things along. I do not recommend this drug unless absolutely necessary.
2.3Patient Review
11/5/2007 I was given this drug to induce labor and told that it would not make my labor any worse. After only 2 hours on the drug, I had very intense contractions with no breaks in between them. I also vomited so much they had to give me an IV. It definitely got my labor going, but I thought the drug was way too strong for my body.
2Patient Review
3/17/2009 I was given this medication to "ripen" my cervix for my first pregnancy. I had a strong reaction to it and couldn't urinate. At the same time, I was also taking Ambien to help me sleep--but the combination just made me hyperactive and groggy. I'm very sensitive to all medications. The Cervidil was removed 5 hours later but my cervix never did get to the stage needed to begin labor. The ease of use of the medication was great; it's just that I wasn't ready yet.
1.7Patient Review
2/16/2013 Unfortunately, we ended up having to get a c-section. I'm not sure if this is because the cervidil didn't work or not, but I wouldn't recommend it based on my experience.
1.3Patient Review
11/1/2018 My cousin and I both tried this treatment, and it failed us miserably. In the end, we both needed C-sections. I'm starting to feel like maybe hospitals just want to keep you longer so they can charge you more.
1Patient Review
4/14/2019 I was really not a fan of this medication. It was quite painful to receive and didn't seem to do much in terms of dilation.
Patient Q&A Section about cervidil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Cervidil induce labor?
"Cervidil is a medication that is used to soften the cervix. It is not typically used to induce labor, but some women may experience cramping or mild contractions while it is working."
Answered by AI
Does Cervidil induction hurt?
"Cervidil may cause backache, cramping, or pink vaginal discharge. It usually takes several hours for these effects to occur. In some cases, contractions may come too close together. If this occurs, please contact the Maternal Infant Child Triage Nurse."
Answered by AI
How quickly does Cervidil work?
"CERVIDIL is a medication used to help prepare the cervix for labor. It is typically given as a single dose, and in clinical trials it was successful in ripening the cervix in the majority of patients. Success was defined as either an increase in the Bishop score at 12 hours, vaginal delivery within 12 hours, or a Bishop score of ≥6 at 12 hours."
Answered by AI
What does Cervidil do for labor?
"If your cervix hasn't begun to dilate and relax on its own, CERVIDIL can help to start the process of cervical ripening, which is necessary for labor to begin."
Answered by AI