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Vagus Nerve Stimulation for Alzheimer's Disease (WALLe Trial)
WALLe Trial Summary
This trial will test whether a non-invasive brain stimulation method can improve cognition in older adults, as well as whether certain individual factors contribute to the effect.
WALLe Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowWALLe Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.WALLe Trial Design
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Who is running the clinical trial?
Media Library
- I have an active blood, kidney, lung, hormone, or liver disorder.I have a serious heart condition or have had a stroke.I have been diagnosed with mild cognitive impairment or dementia.I have had surgery to cut the nerves to my stomach.I have had a severe head injury that made me unconscious or needed hospital care.My medications have not changed in the last 30 days.I have eye conditions like cataracts, glaucoma, or have had certain eye surgeries.I am between 60 and 85 years old.My memory test scores are close to normal for my age and education level.I have low blood pressure because of a nerve system issue.I frequently faint due to sudden drops in my heart rate and blood pressure.I have an active cancer, brain dysfunction due to a metabolic issue, or an infection.I have a serious heart valve problem.My conditions like high blood pressure, high cholesterol, or Type II diabetes are well-managed.I do not have major psychiatric disorders or have not had ECT, but mild depression treated with SSRIs is okay.I have Huntington's disease, hydrocephalus, or a seizure disorder.I have been diagnosed with sick sinus syndrome.
- Group 1: cross-over Sham-Stimulation
- Group 2: Stimulation preceded by cross-over Stimulation-Sham
- Group 3: Stimulation preceded by cross-over Sham-Stimulation
- Group 4: Sham preceded by cross-over Sham-Stimulation
- Group 5: Sham preceded by cross-over Stimulation-Sham
- Group 6: cross-over Stimulation-Sham
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the key goals of this medical study?
"The primary ambition of this scientific endeavour, which is to be assessed over a four week period (cross-over), revolves around the Face-name association memory task. Secondary objectives include evaluating fluctuations in inflammatory responses such as interleukins IL-1β, IL-2, IL-6 and IL-8; tumor necrosis factor alpha (TNFα); macrophage inflammatory protein 1b (MIP1B); monocyte chemoattractant protein 1(MCP1); C1q and C3 complement components. After stability analysis has been conducted with advice from Dr Arnold, specific markers will be selected for"
Is participation in this study limited to individuals under forty years of age?
"This research study invites individuals aged between 60 and 85 years old to take part in it."
Are there still opportunities to join this experiment?
"As indicated on clinicaltrials.gov, enrollment for this medical study is currently open. The trial was initially launched 24th November 2021 and underwent its last update 25th January 2022."
Who is capable of participating in this clinical research?
"This clinical trial is currently inviting applicants aged 60 to 85. The aim is for 140 individuals to join the study."
How many participants is this clinical trial hoping to recruit?
"Affirmative, according to the records on clinicaltrials.gov this medical trial is actively recruiting for participants. This research was first made available November 24th 2021 and has been recently updated January 25th 2022; requiring a total of 140 individuals from 1 locations."
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