Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions for Aging
Study Summary
This trial will test whether a non-invasive brain stimulation method can improve cognition in older adults, as well as whether certain individual factors contribute to the effect.
- Aging
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 8 Secondary · Reporting Duration: Up to 25 weeks: assessed during week 1, week 2, week 8,week 9, week 17 and week 25
Trial Safety
Safety Progress
Trial Design
4 Treatment Groups
Stimulation preceded by cross-over Sham-Stimulation
1 of 4
Stimulation preceded by cross-over Stimulation-Sham
1 of 4
Sham preceded by cross-over Sham-Stimulation
1 of 4
Sham preceded by cross-over Stimulation-Sham
1 of 4
Experimental Treatment
Non-Treatment Group
140 Total Participants · 4 Treatment Groups
Primary Treatment: Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions · Has Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 60 - 85 · All Participants · 10 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
What are the key goals of this medical study?
"The primary ambition of this scientific endeavour, which is to be assessed over a four week period (cross-over), revolves around the Face-name association memory task. Secondary objectives include evaluating fluctuations in inflammatory responses such as interleukins IL-1β, IL-2, IL-6 and IL-8; tumor necrosis factor alpha (TNFα); macrophage inflammatory protein 1b (MIP1B); monocyte chemoattractant protein 1(MCP1); C1q and C3 complement components. After stability analysis has been conducted with advice from Dr Arnold, specific markers will be selected for" - Anonymous Online Contributor
Is participation in this study limited to individuals under forty years of age?
"This research study invites individuals aged between 60 and 85 years old to take part in it." - Anonymous Online Contributor
Are there still opportunities to join this experiment?
"As indicated on clinicaltrials.gov, enrollment for this medical study is currently open. The trial was initially launched 24th November 2021 and underwent its last update 25th January 2022." - Anonymous Online Contributor
Who is capable of participating in this clinical research?
"This clinical trial is currently inviting applicants aged 60 to 85. The aim is for 140 individuals to join the study." - Anonymous Online Contributor
How many participants is this clinical trial hoping to recruit?
"Affirmative, according to the records on clinicaltrials.gov this medical trial is actively recruiting for participants. This research was first made available November 24th 2021 and has been recently updated January 25th 2022; requiring a total of 140 individuals from 1 locations." - Anonymous Online Contributor