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What is Cenestin
Synthetic Conjugated Estrogens, AThe Generic name of this drug
Treatment SummarySynthetic conjugated estrogens A is a medication designed to mimic the effects of hormones in the body. It is used to treat menopause-related symptoms, such as hot flashes, painful intercourse, and vaginal dryness. The medication is made of nine synthetic estrogenic substances derived from plants, such as yam or soy plants. This drug is not to be confused with Conjugated Equine Estrogens (CEEs), which is derived from the urine of pregnant mares and contains a blend of at least 10 estrogen derivatives. Synthetic conjugated estrogens A is marketed under the brand name Enjuvia.
Cenestinis the brand name
Cenestin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cenestin
Synthetic Conjugated Estrogens, A
1999
8
Approved as Treatment by the FDA
Synthetic Conjugated Estrogens, A, also known as Cenestin, is approved by the FDA for 5 uses which include moderate Menopausal Vasomotor Symptoms and severe menopausal vulvovaginal atrophy .moderate Menopausal Vasomotor Symptoms
Helps manage moderate Menopausal Vasomotor Symptoms
severe menopausal vulvovaginal atrophy
Helps manage severe menopausal vulvovaginal atrophy
Menopause
Helps manage severe Vasomotor Symptoms Associated With Menopause
Hot flashes
Helps manage Menopause
moderate Vulvovaginal atrophy
Helps manage moderate Vulvovaginal atrophy
Effectiveness
How Cenestin works in the bodyEstrogen is a hormone that is responsible for the development and maintenance of the female reproductive system. Before menopause, it is produced in the ovaries. After menopause, the production of estrogen drops off significantly, leading to a variety of symptoms. These symptoms can be reduced through Hormone Replacement Therapy (HRT), which replaces estrogen lost during and after menopause with either synthetic or naturally occurring hormones.
When to interrupt dosage
The recommended measure of Cenestin is contingent upon the identified condition, such as Menopause, moderate Menopausal Vasomotor Symptoms and serious menopausal vulvovaginal atrophy. The dosage is contingent upon the method of administration, as outlined in the table below.Condition
Dosage
Administration
moderate Menopausal Vasomotor Symptoms
, 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, 0.45 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral
moderate Vulvovaginal atrophy
, 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, 0.45 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, 0.45 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, 0.45 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral
severe menopausal vulvovaginal atrophy
, 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg, 0.45 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Cenestin has ten contraindications and should not be employed while enduring the conditions in the below table.Cenestin ContraindicationsCondition
Risk Level
Notes
Thromboembolism
Do Not Combine
Liver Dysfunction
Do Not Combine
Breast Cancer
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Breast
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Pulmonary Embolism
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Common Cenestin Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Synthetic Conjugated Estrogens, A.
Dasabuvir
Major
The risk or severity of liver enzyme elevations can be increased when Synthetic Conjugated Estrogens, A is combined with Dasabuvir.
Exemestane
Major
The therapeutic efficacy of Exemestane can be decreased when used in combination with Synthetic Conjugated Estrogens, A.
Ombitasvir
Major
The risk or severity of liver enzyme elevations can be increased when Synthetic Conjugated Estrogens, A is combined with Ombitasvir.
Ospemifene
Major
The risk or severity of adverse effects can be increased when Synthetic Conjugated Estrogens, A is combined with Ospemifene.
Cenestin Novel Uses: Which Conditions Have a Clinical Trial Featuring Cenestin?
16 active trials are investigating the efficacy of Cenestin in mitigating symptoms associated with Menopause, moderate Menopausal Vasomotor Symptoms and Menopause-related disorders.Condition
Clinical Trials
Trial Phases
moderate Vulvovaginal atrophy
0 Actively Recruiting
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Menopause
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Cenestin Reviews: What are patients saying about Cenestin?
5Patient Review
6/4/2014 Despite what you may have heard, Cenestin has not been discontinued. I called the manufacturer today and they said that while the 1.25 mg tablets are unavailable at the moment, the smaller dosage tablets (.3 and .45 mg) are still available.
5Patient Review
1/22/2015 I had been taking Cenestin for 13 years with great results. Then I could not get it anymore and I was put on Premarin. After only a few weeks my hair was falling out, brittle nails, 7/24 heartburn so I had to take Prilosec. I stopped the Premarin and now have hot flashes all the time. Wish they would bring it back again.
5Patient Review
8/23/2014 I've been taking this medication for over a decade and it's really helped me. I don't have any of the negative side effects that come with menopause, and I'm thankful for that. However, when I was switched to Premarin 1.25, it was like taking no medication at all—my life turned upside down.
5Patient Review
9/3/2014 I've used Cenestin .625 for almost 20 years and it's been amazing. I'm so upset that Teva is no longer making it. Hopefully there's another medication out there that can give me the same results.
5Patient Review
8/10/2013 Cenestin is extremely effective for me, but the price is quite high. It was the only medication I tried that had no negative side effects and actually made me feel better than normal.
5Patient Review
7/13/2015 Cenestin was really the best medication I tried after my hysterectomy in 2004. It alleviated hot flashes, night sweats, and overall made me feel great. Unfortunately, the company stopped making it and I haven't been able to find anything that comes close to working as well since then.
5Patient Review
10/25/2017 I haven't been able to find Cenestin recently, is it no longer being made? When I took it before I always felt much better.
5Patient Review
4/13/20115Patient Review
10/11/20115Patient Review
2/2/2012 I had a hysterectomy 15 years ago and have been on Cenestin since. I just recently stopped taking them,I was concerned about the length of time I have been on them and things have been horrible since I stopped, nite sweats,hot flashes,mood swings and NO desire. I'm ready to go back to taking them again. It worked wonders for me!
4Patient Review
3/21/2014 I've been taking Cenestin for years with great results, but now that it's been discontinued I have to switch to something else. Not happy about it!!!
4Patient Review
12/30/2011Patient Q&A Section about cenestin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Cenestin?
"The side effects of birth control pills can include: nausea, vomiting, bloating, stomach cramps, breast tenderness/pain/swelling, headache, changes in weight or appetite, and freckles or darkening of facial skin."
Answered by AI
Do they still make Cenestin?
"The Cenestin brand of medication has been discontinued in the United States. However, if generic versions of this product have been approved by the U.S. Food and Drug Administration (FDA), there may be generic equivalents of Cenestin available."
Answered by AI
What is Cenestin used for?
"This medication is a female hormone that is used to help reduce symptoms of menopause. The symptoms are caused by the body making less estrogen."
Answered by AI
What is Cenestin made of?
"Cenestin, a medication made from soy and yam plants, will be available to prescribe within 90 days in two dosages--0.625 mg and 0.9 mg."
Answered by AI