Ceclor

Tonsillitis, Bacteria, Otitis Media + 9 more

Treatment

2 FDA approvals

6 Active Studies for Ceclor

What is Ceclor

Cefaclor

The Generic name of this drug

Treatment Summary

Cefprozil is a semi-synthetic, broad-spectrum antibiotic that is derived from cephalexin. It is used to treat bacterial infections.

Cefaclor

is the brand name

image of different drug pills on a surface

Ceclor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cefaclor

Cefaclor

1995

47

Approved as Treatment by the FDA

Cefaclor, also known as Cefaclor, is approved by the FDA for 2 uses including Bacterial Infections and Urinary Tract Infection (UTI) .

Bacterial Infections

Urinary Tract Infection (UTI)

Effectiveness

How Ceclor Affects Patients

Cefaclor is a type of antibiotic that works by stopping the growth of bacteria. It is effective against many types of bacteria, including Gram-positive aerobes like Staphylococci and Streptococcus, and Gram-negative aerobes like Escherichia coli, Haemophilus influenzae, Klebsiella sp., and Proteus mirabilis.

How Ceclor works in the body

Cefaclor is an antibiotic that works similarly to penicillins. It attaches to proteins inside the bacterial cell wall, which stops the bacteria from making more cell walls. This causes the bacteria to rupture and die. It's also thought that cefaclor may interfere with a protein that stops cell rupture.

When to interrupt dosage

The proposed amount of Ceclor depends upon the diagnosed condition, including streptococcus pyogenes skin infection, Urinary Tract Infection (UTI) and Otitis Media. The dosage will differ, contingent on the administration approach delineated in the table underneath.

Condition

Dosage

Administration

Urinary tract infection

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Tonsillitis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

streptococcus pyogenes skin infection

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Staphylococcal Skin Infections

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bacterial Infections

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bacteria

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Streptococcal Pharyngitis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bronchitis, Chronic

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Moraxella catarrhalis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Bronchitis

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Otitis Media

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Urinary Tract Infection (UTI)

, 500.0 mg, 250.0 mg/mL, 375.0 mg/mL, 125.0 mg/mL, 250.0 mg, 187.0 mg/mL, 375.0 mg, 50.0 mg/mL, 75.0 mg/mL, 25.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension, Capsule, Capsule - Oral, Powder, Powder - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, For suspension, For suspension - Oral

Warnings

There are 20 known major drug interactions with Ceclor.

Common Ceclor Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Neomycin.

Tenofovir

Major

Cefaclor may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Cefaclor may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Cefaclor may increase the nephrotoxic activities of Tenofovir disoproxil.

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Cefaclor.

Ceclor Toxicity & Overdose Risk

Overdosing on Penicillin can lead to symptoms such as diarrhea, nausea, stomach discomfort, and vomiting.

image of a doctor in a lab doing drug, clinical research

Ceclor Novel Uses: Which Conditions Have a Clinical Trial Featuring Ceclor?

29 active clinical trials are currently assessing the effectiveness of Ceclor in managing Streptococcal Pharyngitis, Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae and Moraxella catarrhalis.

Condition

Clinical Trials

Trial Phases

Bronchitis, Chronic

0 Actively Recruiting

Bacteria

0 Actively Recruiting

Urinary Tract Infection (UTI)

6 Actively Recruiting

Phase 1, Phase 3, Phase 4, Phase 2

Urinary tract infection

0 Actively Recruiting

Tonsillitis

0 Actively Recruiting

Bronchitis

0 Actively Recruiting

Moraxella catarrhalis

0 Actively Recruiting

streptococcus pyogenes skin infection

0 Actively Recruiting

Streptococcal Pharyngitis

0 Actively Recruiting

Otitis Media

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Staphylococcal Skin Infections

0 Actively Recruiting

Ceclor Reviews: What are patients saying about Ceclor?

5

Patient Review

4/21/2010

Ceclor for Middle Ear Infection

I really appreciate how this medication is easy on my system. I'm one of the few people who doesn't react to it, and I think it works great.

5

Patient Review

2/13/2014

Ceclor for Pneumonia

I had a terrible bout of pneumonia, but this medication was the only thing that finally cleared it up.

4.7

Patient Review

9/29/2011

Ceclor for Acute Infection of the Nose, Throat or Sinus

It's a great product, but it can be tough to track down.

3.7

Patient Review

2/5/2009

Ceclor for Acute Infection of the Nose, Throat or Sinus

Unfortunately, I had a very severe allergic reaction to this medication. It put me in the hospital for days and I was out of work for over two weeks.

2.3

Patient Review

8/30/2010

Ceclor for Acute Infection of the Nose, Throat or Sinus

I was prescribed this medication over fifteen years ago and quickly found that it made my joints incredibly stiff and painful. I discontinued use and called my doctor, but they claimed the medicine couldn't be the cause. I ended up taking Neproxin for months to recover from the stiffness and pain before changing doctors.

2

Patient Review

12/15/2013

Ceclor for Bacterial Pneumonia caused by Haemophilus Influenzae

Unfortunately, I had a really negative reaction to Ceclor. I ended up vomiting and was so dehydrated that I had to go to the emergency room. My liver also wasn't doing well - I would advise you to stay away from this drug if possible.

2

Patient Review

10/21/2011

Ceclor for Acute Infection of the Nose, Throat or Sinus

I had an allergic reaction to this drug and developed hives and intense itching all over my body. I would not recommend it to others.

2

Patient Review

12/12/2007

Ceclor for Acute Infection of the Nose, Throat or Sinus

Unfortunately, my son had a severe allergic reaction to ceclor in the form of hives. I have since learned that many people share this same allergy.

1.7

Patient Review

4/24/2014

Ceclor for Acute Infection of the Nose, Throat or Sinus

Doctor prescribed this for a throat-sinus infection, even though I am allergic to penicillin (a big no-no). Back started itching really bad and swelled up with hives. He gave me an antidote (can't remember) and the hives went away. Told me to stop taking it. Ceclor is a cephalosporin type drug. I now tell all my Doctors about my allergic reaction to Ceclor and Penicillin to be safe.

1.7

Patient Review

2/4/2008

Ceclor for Acute Infection of the Nose, Throat or Sinus

My son and I both had an allergic reaction to this drug.

1.3

Patient Review

8/10/2009

Ceclor for Urinary Tract Infection

This medicine caused me a lot of pain in the form of headaches. I would not recommend it to others seeking relief.

1

Patient Review

2/26/2008

Ceclor for Middle Ear Infection

My son had a terrible reaction to this drug, with hives and major gastrointestinal issues. Avoid it if you can.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ceclor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of drug is Ceclor?

"It will not work for virus infections (such as colds, flu).

This antibiotic is used to treat a variety of bacterial infections. It works by stopping the growth of bacteria. This antibiotic only treats bacterial infections and will not work on viruses."

Answered by AI

Is Ceclor a penicillin?

"They both fight bacteria, but cephalosporins are better at fighting certain types of bacteria.

Is Ceclor a penicillin? Ceclor is a cephalosporin, which is a class of antibiotics that are similar to penicillin. They both fight bacteria, but cephalosporins are more effective against certain types of bacteria."

Answered by AI

What is Ceclor antibiotic used for?

"Cefaclor is used to treat infections caused by bacteria, such as pneumonia and other lower respiratory tract (lung) infections; and infections of the skin, ears, throat, tonsils, and urinary tract."

Answered by AI

Is Ceclor the same as amoxicillin?

"Cefaclor, which is found in Cefaclor Oral Suspension, is not as effective as amoxicillin-based drugs in treating infections, according to a randomized controlled trial."

Answered by AI

Clinical Trials for Ceclor

Image of Harbor UCLA Medical Center - Medicine - Infectious Diseases in Torrance, United States.

Optimized Beta-lactam Dosing for Bacterial Infections

18+
All Sexes
Torrance, CA

The purpose of this study is to evaluate the abilities of Cystatin C (CysC) and CysC-based estimated Glomerular Filtration Rate (eGFR) equations to characterize the pharmacokinetics (PK) profiles of meropenem and cefepime relative to Serum Creatinine (SCR), Serum Creatinine based Equation (SCRE)and iohexol at the population and individual levels in critically ill adult patients with suspected or documented AMR Gram-negative infections. We hypothesize that CysC and CysC-based eGFR equations will characterize the PK profiles of meropenem and cefepime at the population and individual levels with greater accuracy and precision than SCR and SCREs. Iohexol will be administered to patients enrolled in the study and serve as the reference indicator of measured Glomerular Filtration Rate (mGFR), which is the gold standard assessment of kidney function. We hypothesize that the predictive performances of CysC and CysC-based eGFR equations in estimating the PK profiles of meropenem and cefepime at the population and individual levels will be comparable to iohexol. The information obtained in this study will be used to develop PK/pharmacodynamics (PD) optimized meropenem and cefepime dosing schemes based on the renal function biomarker population PK (PopPK) model with the best predictive performance for clinical use in the treatment of critically ill adult patients with suspected or documented AMR Gram-negative infections and varying degrees of renal function. The primary objective of this study is to compare the abilities of renal function biomarkers (CysC, CysC-based eGFR equations, SCR, SCREs) relative to iohexol to characterize the PK profiles of meropenem and cefepime in critically ill adult patients with suspected or documented AMR Gram-negative infections.

Phase 4
Recruiting

Harbor UCLA Medical Center - Medicine - Infectious Diseases (+9 Sites)

Image of University of Missouri in Columbia, United States.

Antibiotics for Cat Bite Injuries

18+
All Sexes
Columbia, MO

Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries. Pasteurella multocida is the is the most common organism isolated from the mouths of cats that can cause infections after a bite. Prophylactic antibiotics are often recommended with amoxicillin-clavulanate for 3-5 days to decrease the incidence of developing an infection. However, only one randomized controlled clinical trial consisting of 12 patients has been performed to justify this course of treatment, raising the possibility that the use of antibiotics could be reduced or even eliminated. Investigators will compare different durations of prophylactic antibiotics and a placebo control for cat bites to the hand/forearm presenting to the Emergency Department, Urgent Care, Plastic Surgery Clinic using a randomized, controlled, double-blind clinical trial. Participants presenting to the University of Missouri Hospital Emergency Department, Missouri University (MU) Healthcare Urgent Care, Plastic Surgery Clinic over the next year will be offered the chance to enroll if they meet the inclusion/exclusion criteria. For inclusion, participants will be \>18 years of age, have cat bites to the hand or distal to elbow, and present within 24 hours of the cat bite injury. Participants must not present with active local or systemic infections, have received antibiotics within the past 30 days, or be immunocompromised (primary and secondary immunodeficiencies). Participants will be randomized to one of three treatment arms (placebo; amoxicillin-clavulanate 1 day; amoxicillin-clavulanate 5 days). Outcomes are the development of an infection at the location of the cat bite and/or systemic infection, adverse effects of interventions, disability assessed by Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) scores, and quality of life (QOL) assessed by HAND Questionnaire (HAND-Q) scores. Infection will be assessed at day 0, day 2, day 7+/-2, day 14+/-2, and day 30+/-2 by vital signs, laboratory values, physical examination and with an infrared and digital camera. All measures will be within the standard of care, apart from the infrared camera, QuickDASH, and HAND-Q scores. The anatomic locations of cat bites to the hand/forearm will be assessed for correlations with infections.

Phase 4
Recruiting

University of Missouri

Kevin M Klifto, DO, PharmD

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