Cafergot

Vascular Headaches, Postpartum state, Cluster Headache + 2 more
Treatment
4 FDA approvals
20 Active Studies for Cafergot

What is Cafergot

ErgotamineThe Generic name of this drug
Treatment SummaryCaffeine is a drug found in coffee beans, tea, and cocoa beans that is used for a variety of purposes. It is most commonly used to treat drowsiness and is found in many cosmetic products. It can be ingested, inhaled, injected, or applied topically. Caffeine was first approved by the FDA in 1999 as an injection to treat apnea in premature babies. Premature birth can lead to apnea and bronchopulmonary dysplasia, and caffeine is beneficial in preventing and treating these conditions, improving the quality of life of premature infants.
Cafergotis the brand name
Cafergot Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cafergot
Ergotamine
1953
15

Approved as Treatment by the FDA

Ergotamine, also known as Cafergot, is approved by the FDA for 4 uses which include Cluster Headache and Vascular Headaches .
Cluster Headache
Vascular Headaches
Used to treat Vascular Headaches in combination with Caffeine
Migraine
Neuralgia

Effectiveness

How Cafergot Affects PatientsCaffeine helps wake you up and can make you feel more alert. It can also make you feel jittery or anxious at times. It can help relax your muscles, make your heart beat faster, and even improve your sports performance. Caffeine can increase stomach acid production and speed up digestion, and it is often combined with other medications to relieve migraine and headache symptoms. Finally, caffeine is a mild diuretic and can help your body get rid of extra fluid.
How Cafergot works in the bodyCaffeine works in many different ways to affect the body. It blocks certain enzymes and receptors to help with alertness, causes diuretic effects, releases catecholamines, and dilates blood vessels. This can lead to increased respiratory drive, stimulation of heart contractility, and increased blood pressure for those who don't consume it regularly. Caffeine can also help with migraines and headaches by constricting the blood vessels in the brain.

When to interrupt dosage

The recommended quantity of Cafergot is contingent upon the diagnosed condition, such as Overdose, Drug, Catarrh and Athletic Performance. The portion of dosage will vary as per the technique of delivery (e.g. Tablet or Tablet - Oral) detailed in the table below.
Condition
Dosage
Administration
Migraine
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Vascular Headaches
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Cluster Headache
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Postpartum state
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Uterine Inertia
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral

Warnings

Cafergot has one contraindication, therefore it should not be consumed under the circumstances specified in the table below.Cafergot Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Renal Insufficiency
Do Not Combine
Coronary Heart Disease
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Cafergot.
Common Cafergot Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Ergotamine.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Ergotamine.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ergotamine.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ergotamine.
4-Bromo-2,5-dimethoxyphenethylamine
Major
Ergotamine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
Cafergot Toxicity & Overdose RiskCaffeine is toxic to rats in doses greater than 192 mg/kg. In humans, an overdose of around 10-14 grams is fatal. Signs of caffeine overdose may include seizures, nausea, vomiting, diarrhea, restlessness, anxiety, increased heart rate, and tremors. In severe cases, it can lead to death. To treat a caffeine overdose, medical professionals may use activated charcoal, hemodialysis, benzodiazepines, IV fluids, vasopressors, magnesium, and beta blockers. If arrhythmias are present, attempts to resuscitate may be necessary.
image of a doctor in a lab doing drug, clinical research

Cafergot Novel Uses: Which Conditions Have a Clinical Trial Featuring Cafergot?

Presently, 429 active trials are underway to investigate the potential of Cafergot to alleviate Chronic Fatigue Syndrome, Chronic Pain and Migraine symptoms.
Condition
Clinical Trials
Trial Phases
Migraine
53 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Vascular Headaches
0 Actively Recruiting
Postpartum state
9 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2
Uterine Inertia
0 Actively Recruiting
Cluster Headache
3 Actively Recruiting
Phase 1, Phase 2

Cafergot Reviews: What are patients saying about Cafergot?

5Patient Review
5/17/2012
Cafergot for Migraine Headache
It's so frustrating that this medication is no longer available; it worked perfectly for me! I've been dealing with migraines for 28 years, and I can't take the newer class of migraine medications because they cause shortness of breath. Fioricet works just as well as Cafergot did, but it's not a long-term solution.
5Patient Review
5/5/2012
Cafergot for Migraine Headache
I've been taking this medication for years and it's the only thing that has ever helped me with my migraines. I'm really disappointed that it's no longer on the market, and would love to know if anyone has found anything similar that works just as well.
5Patient Review
2/10/2012
Cafergot for Migraine Headache
I've been taking cafergot for 20 years and I can't imagine how you all suffer without it. Fortunately, it's still available in Asia today. You can buy it in Indonesia or Singapore.
5Patient Review
11/6/2013
Cafergot for Migraine Headache
I've been taking Cafergot for migraines since the late '70s, and they always worked perfectly for me. When I couldn't get them anymore, I switched to Fioricet and it works just as well.
5Patient Review
9/20/2013
Cafergot for Migraine Headache
I adore this medication! It's by far the best I've ever tried for migraines. But it's not carried where I live, which is so frustrating. Does anyone know if it can be purchased elsewhere?
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cafergot

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Cafergot tablets used for?

"This medication is a combination of drugs that is used to either treat or prevent specific types of headaches. These headaches are caused by the widening of blood vessels in the head. Ergotamine works by narrowing these widened blood vessels."

Answered by AI

Why was Cafergot taken off the market?

"Cafergot was removed from store shelves because it was too costly. Migergot does the same job but the base ingredient is not as strong, and it caused me abdominal swelling and bloating."

Answered by AI

Is Cafergot good for migraine?

"Cafergot will only provide relief for an already existing headache, not preventing future migraines or reducing the number of attacks. It also shouldn't be used to treat tension headaches that seem different from your regular migraines."

Answered by AI

What class of drug is Cafergot?

"Cafergot is a prescription drug that can help relieve the symptoms of migraines. It may be used on its own or in combination with other medications. Cafergot works by belong to a class of drugs called Ergot Alkaloids, which help to constrict blood vessels and reduce inflammation."

Answered by AI

Clinical Trials for Cafergot

Have you considered Cafergot clinical trials? We made a collection of clinical trials featuring Cafergot, we think they might fit your search criteria.
Have you considered Cafergot clinical trials? We made a collection of clinical trials featuring Cafergot, we think they might fit your search criteria.
Have you considered Cafergot clinical trials? We made a collection of clinical trials featuring Cafergot, we think they might fit your search criteria.
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