Bupropion Hydrochloride

Smoke, Reducing diet, Seasonal Affective Disorder + 5 more
Treatment
3 FDA approvals
20 Active Studies for Bupropion Hydrochloride

What is Bupropion Hydrochloride

BupropionThe Generic name of this drug
Treatment SummaryBupropion (brand name Wellbutrin) is an antidepressant that works by blocking the reuptake of norepinephrine and dopamine in the brain, prolonging their action. It is used to treat major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking. Unlike most other antidepressants, bupropion does not cause sexual side effects, sedation, or weight gain. Bupropion is also sometimes used in combination with naltrexone to help people with chronic weight management issues by increasing the firing rate of certain neurons in the brain that regulate appetite.
Wellbutrinis the brand name
image of different drug pills on a surface
Bupropion Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741

Approved as Treatment by the FDA

Bupropion, also known as Wellbutrin, is approved by the FDA for 3 uses which include Smoke and Smoking Cessation .
Smoke
Smoking Cessation
Depression

Effectiveness

How Bupropion Hydrochloride Affects PatientsBupropion is an antidepressant medication that works differently from other antidepressants. It is a weaker inhibitor of norepinephrine and dopamine, and does not inhibit monoamine oxidase. Bupropion has mild stimulant effects, which could make it habit-forming. It can also lower the seizure threshold and increase blood pressure, so it should not be taken by those with existing seizure or hypertension conditions. Clinical trials suggest that bupropion can increase systolic blood pressure by 1.3 mmHg on average.
How Bupropion Hydrochloride works in the bodyBupropion is a drug that increases the effects of certain brain chemicals, like norepinephrine and dopamine. It is used to treat depression, help with smoking cessation, and can even aid in weight management. Bupropion works by blocking the enzymes that absorb these brain chemicals after they are released. This means the effects of these chemicals last longer. It does not have any serious side effects, such as weight gain or sexual side effects, like other antidepressants. When used for smoking cessation, bupropion mimics the effects of nicotine and can help people fight cravings. When used for weight loss, bupropion works

When to interrupt dosage

The proposed dosage of Bupropion Hydrochloride is contingent upon the diagnosed condition, including Depressive Bipolar Disorder, Depression and Disease. The measure of dosage differs, in line with the mode of administration (e.g. Tablet, extended release or Tablet, film coated, extended release) depicted in the table underneath.
Condition
Dosage
Administration
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Warnings

Bupropion Hydrochloride Contraindications
Condition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
There are 20 known major drug interactions with Bupropion Hydrochloride.
Common Bupropion Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Bupropion Hydrochloride Toxicity & Overdose RiskOverdosing on aripiprazole may lead to seizures, hallucinations, fainting, unusually fast heartbeat, and sudden stoppage of the heart.
image of a doctor in a lab doing drug, clinical research

Bupropion Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Bupropion Hydrochloride?

Presently, there are 490 active clinical trials investigating the capacities of Bupropion Hydrochloride in treating Attention Deficit Hyperactivity Disorder, Depression and Smoking Cessation.
Condition
Clinical Trials
Trial Phases
Obesity
134 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Attention Deficit Hyperactivity Disorder
71 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Smoking Cessation
97 Actively Recruiting
Early Phase 1, Phase 2, Phase 4, Not Applicable, Phase 1, Phase 3
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Smoke
0 Actively Recruiting
Mood Disorders
21 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1
Seasonal Affective Disorder
0 Actively Recruiting
Reducing diet
0 Actively Recruiting

Bupropion Hydrochloride Reviews: What are patients saying about Bupropion Hydrochloride?

5Patient Review
10/15/2022
Bupropion Hydrochloride for Depression
Though it took a little while to start working, I stuck with the medication and I'm really glad that I did. It's made such a difference in my day-to-day life; things that used to feel like a drag now don't phase me. If you're considering this treatment, just be patient for a couple of weeks and you'll see the benefits too.
4.3Patient Review
11/11/2022
Bupropion Hydrochloride for Depression
I experienced fantastic results with this treatment, but unfortunately had to discontinue use because it was causing severe hair loss.
3.7Patient Review
9/19/2022
Bupropion Hydrochloride for Depression
I didn't feel like this worked as well for me as the regular Wellbutrin 100mg. I think it's because it's a generic brand; when it comes to depression, I need something that packs more of a punch.
2.7Patient Review
5/1/2022
Bupropion Hydrochloride for Depression
I didn't find that this addition to my Prozac increased my sex drive as I'd hoped.
2Patient Review
5/5/2022
Bupropion Hydrochloride for Depression
I experienced a range of unpleasant side effects from this treatment that made it not worth continuing for me.
2Patient Review
6/5/2022
Bupropion Hydrochloride for Depression
I had a bad reaction when I mixed these two drugs. My heart was racing and it felt like my blood vessels were going to burst.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bupropion hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does bupropion hydrochloride do?

"Bupropion hydrochloride (HCL) is an antidepressant used to help people quit smoking and to treat a variety of conditions, including depression and other mental/mood disorders. Antidepressants can help prevent suicidal thoughts/attempts and provide other important benefits."

Answered by AI

Is bupropion HCl the same as Wellbutrin?

"The brand name for bupropion HCl sustained-release tablets is Wellbutrin SR. It was approved by the U.S Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in 1996. The brand name for bupropion HCl extended-release tablets is Wellbutrin XL."

Answered by AI

What are the side effects of bupropion?

"feeling restless, dizzy or light-headed;;

Dry mouth, sore throat, stuffy nose, ringing in the ears, blurred vision, nausea, vomiting, stomach pain, loss of appetite, constipation, sleep problems (insomnia), tremors, sweating, feeling anxious or nervous, fast heartbeats, confusion, agitation, hostility, feeling restless, dizzy or light-headed."

Answered by AI

Is Xanax the same as bupropion?

"Do Wellbutrin and Xanax treat the same thing?

Wellbutrin and Xanax are used to treat different types of mental illness/mood disorders. Wellbutrin is used to manage major depression and seasonal affective disorder. Xanax is used to treat panic attacks and anxiety disorders."

Answered by AI

Clinical Trials for Bupropion Hydrochloride

Have you considered Bupropion Hydrochloride clinical trials? We made a collection of clinical trials featuring Bupropion Hydrochloride, we think they might fit your search criteria.
Have you considered Bupropion Hydrochloride clinical trials? We made a collection of clinical trials featuring Bupropion Hydrochloride, we think they might fit your search criteria.
Have you considered Bupropion Hydrochloride clinical trials? We made a collection of clinical trials featuring Bupropion Hydrochloride, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top