Buprenorphine Hydrochloride

Pain, Opioid-Related Disorders, Pain

Treatment

2 FDA approvals

0 Active Studies for Buprenorphine Hydrochloride

What is Buprenorphine Hydrochloride

Buprenorphine

The Generic name of this drug

Treatment Summary

Naloxone is a medication used to reverse the effects of opioid drugs and prevent overdoses. It works by blocking opioid receptors in the brain and stopping opioid drugs from having an effect. Naloxone is commonly known under the brand name Narcan and is available as an injection, nasal spray, or IV infusion. Naloxone is also combined with buprenorphine in the product Suboxone, used to treat opioid addiction. It is very safe to use and has few side effects, but can cause withdrawal symptoms if given to someone taking opioid drugs. Naloxone can be used to save someone’s

Buprenex

is the brand name

image of different drug pills on a surface

Buprenorphine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Buprenex

Buprenorphine

1985

261

Approved as Treatment by the FDA

Buprenorphine, commonly known as Buprenex, is approved by the FDA for 2 uses which include Opioid Dependence and Opioid-Related Disorders .

Opioid Dependence

Used to treat Opioid Dependence in combination with Naloxone

Opioid-Related Disorders

Used to treat Opioid Dependence in combination with Naloxone

Effectiveness

How Buprenorphine Hydrochloride Affects Patients

Naloxone is used to quickly reverse the effects of opioid overdoses. It does not last as long as opioids, so multiple doses may be necessary. Naloxone will not have any effect if no opioids have been taken by the patient. Those given naloxone might experience opioid withdrawal. Additionally, the overdose may not be completely reversed if other drugs are involved.

How Buprenorphine Hydrochloride works in the body

Naloxone is a drug that prevents opioids from binding to the body's opioid receptors. It works to reverse the effects of opioids in people who have taken them, but has no effect on those who have not.

When to interrupt dosage

The advocated dosage of Buprenorphine Hydrochloride is contingent upon the determined condition, including Opioid Dependence, Pain and Septic Shock. The volume of dosage is contingent upon the method of delivery (e.g. Spray, metered or Tablet) detailed in the table below.

Condition

Dosage

Administration

Pain

0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film, Film - Buccal, Injection - Intramuscular; Intravenous, Injection, Tablet, orally disintegrating - Sublingual, Tablet, orally disintegrating, Patch, Patch - Transdermal, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution - Subcutaneous, Solution, Film, soluble - Buccal; Sublingual, Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous

Opioid-Related Disorders

0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film, Film - Buccal, Injection - Intramuscular; Intravenous, Injection, Tablet, orally disintegrating - Sublingual, Tablet, orally disintegrating, Patch, Patch - Transdermal, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution - Subcutaneous, Solution, Film, soluble - Buccal; Sublingual, Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous

Pain

0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film, Film - Buccal, Injection - Intramuscular; Intravenous, Injection, Tablet, orally disintegrating - Sublingual, Tablet, orally disintegrating, Patch, Patch - Transdermal, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution - Subcutaneous, Solution, Film, soluble - Buccal; Sublingual, Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous

Warnings

Buprenorphine Hydrochloride Contraindications

Condition

Risk Level

Notes

Alcohol Withdrawal Delirium

Do Not Combine

Asthma

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

suspected gastrointestinal obstruction

Do Not Combine

Pulse Frequency

Do Not Combine

Asthma

Do Not Combine

Gastrointestinal obstruction

Do Not Combine

Head

Do Not Combine

ethanol

Do Not Combine

Stomatitis

Do Not Combine

Abdomen

Do Not Combine

severe CNS depression

Do Not Combine

opioid naive

Do Not Combine

Myasthenia Gravis

Do Not Combine

Epilepsy

Do Not Combine

Hypocalcemia

Do Not Combine

Hypokalemia

Do Not Combine

Hypomagnesemia

Do Not Combine

Mental Depression

Do Not Combine

Cerebrospinal Fluid

Do Not Combine

Long QT Syndrome

Do Not Combine

There are 20 known major drug interactions with Buprenorphine Hydrochloride.

Common Buprenorphine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Buprenorphine.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Buprenorphine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Buprenorphine.

Buprenorphine Hydrochloride Toxicity & Overdose Risk

If a person has not taken opioids, naloxone will not have a major impact on them. In mice and rats, the lowest toxic dose when taken orally is greater than 1g/kg. When administered intraperitoneally, the lowest toxic dose is 80mg/kg in mice and 239mg/kg in rats. For subcutaneous administration, the lowest toxic dose is 286mg/kg in mice and 500mg/kg in rats.

image of a doctor in a lab doing drug, clinical research

Buprenorphine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Buprenorphine Hydrochloride?

64 active clinical trials are currently investigating the potential of Buprenorphine Hydrochloride to alleviate Opioid Dependency, Opioid-Induced Pain, and other Pain Disorders.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Pain

0 Actively Recruiting

Opioid-Related Disorders

0 Actively Recruiting

Buprenorphine Hydrochloride Reviews: What are patients saying about Buprenorphine Hydrochloride?

5

Patient Review

6/4/2018

Buprenorphine Hydrochloride for Pain

Buprenorphine completely changed my life for the better. I had been struggling with painkiller addiction for years, and this medication allowed me to get my life back on track. I highly recommend it to anyone who is struggling with a similar problem.

5

Patient Review

3/28/2021

Buprenorphine Hydrochloride for Pain

This medication has completely changed my life for the better. I was taking hydrocodone, gabapentin, and oxycodone for nerve pain, but this treatment is much more effective with no withdrawals.

5

Patient Review

7/4/2022

Buprenorphine Hydrochloride for Chronic Pain

I've been on Buprenorphine for two months now, and it's by far the best pain medication I've ever tried. Before, my pain would only last for 4 hours before coming back, but now I'm getting 6-8 hours of relief. It's definitely changed my life for the better and I would encourage anyone in chronic pain to give it a try!

5

Patient Review

1/28/2020

Buprenorphine Hydrochloride for Prevention of Opiate Drug Abuse

This medication saved my life. I went off of it for a short period and in time, I was back to narcotics. I ran back to my doctor and asked him to prescribe it again. I plan on being on this until I die. My mood is so much better, even though it doesnâ??t advertise as a mood enhancer.

5

Patient Review

9/6/2019

Buprenorphine Hydrochloride for Chronic Pain

I was a little bit out of it after taking this medication, but it did help with my overall pain.

4

Patient Review

2/1/2019

Buprenorphine Hydrochloride for Chronic Pain

I used this for several years to get off opioids, which I was addicted to. This helped with my chronic back pain. However, a new doctor switched me to methadone, which works MUCH better. Been on methadone for 5 years now and although it is addictive, it too helps with pain and although it can be abused, you learn not to.

3.7

Patient Review

6/15/2022

Buprenorphine Hydrochloride for Chronic Pain

I am only getting minimal relief from this medication, even though I am following the instructions to dissolve it under my tongue.

3.3

Patient Review

6/17/2021

Buprenorphine Hydrochloride for Chronic Pain

I was on opioids for 10 years, and had no issues getting off of them. I changed my pain doctor, but he is too conservative for me. This pill is not effective for me, and maybe a stronger dose would be better. I'm going to give it a week but at this point, I do not recommend this treatment.

2

Patient Review

3/10/2020

Buprenorphine Hydrochloride for Chronic Pain

This was worse than kicking my morphine habit and the withdrawal lasted for weeks.

1.3

Patient Review

4/24/2021

Buprenorphine Hydrochloride for Chronic Pain

This medication failed me not once, but twice in two different years. I was only able to get it a third time because of a change in hospital policy that left patients like me who have been relying on opioids for chronic pain for 19 years out to dry. There is zero relief for people in my position.

1.3

Patient Review

9/12/2019

Buprenorphine Hydrochloride for Narcotic Addiction

Hard to obtain if you don't have insurance.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about buprenorphine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Buprenorphine Hydrochloride a drug?

"Buprenorphine is a drug used to relieve pain. It was first marketed in the United States in 1985 as a drug with a low potential for abuse."

Answered by AI

Is Buprenorphine hydrochloride the same as Suboxone?

"Buprenorphine is a medication used to treat opioid dependence or moderate to severe pain. It is not the same as Suboxone, which is a two-ingredient drug used only to treat opioid dependence."

Answered by AI

Is Buprenorphine hydrochloride a narcotic?

"Buprenorphine is an opioid partial agonist, a type of narcotic. It's used in higher doses to treat opioid addiction and dependence, and in lower doses to treat moderate to severe pain."

Answered by AI

What is the drug buprenorphine used for?

"Buprenorphine and the combination of buprenorphine and naloxone can help treat opioid dependence. This is when someone is addicted to drugs like heroin or painkillers."

Answered by AI