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What is Buprenorphine Hydrochloride
BuprenorphineThe Generic name of this drug
Treatment SummaryNaloxone is a medication used to reverse the effects of opioid drugs and prevent overdoses. It works by blocking opioid receptors in the brain and stopping opioid drugs from having an effect. Naloxone is commonly known under the brand name Narcan and is available as an injection, nasal spray, or IV infusion. Naloxone is also combined with buprenorphine in the product Suboxone, used to treat opioid addiction. It is very safe to use and has few side effects, but can cause withdrawal symptoms if given to someone taking opioid drugs. Naloxone can be used to save someone’s
Buprenexis the brand name
Buprenorphine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261
Approved as Treatment by the FDA
Buprenorphine, commonly known as Buprenex, is approved by the FDA for 1 uses which include Opioid Dependence .Opioid Dependence
Used to treat Opioid Dependence in combination with Naloxone
Effectiveness
How Buprenorphine Hydrochloride Affects PatientsNaloxone is used to quickly reverse the effects of opioid overdoses. It does not last as long as opioids, so multiple doses may be necessary. Naloxone will not have any effect if no opioids have been taken by the patient. Those given naloxone might experience opioid withdrawal. Additionally, the overdose may not be completely reversed if other drugs are involved.
How Buprenorphine Hydrochloride works in the bodyNaloxone is a drug that prevents opioids from binding to the body's opioid receptors. It works to reverse the effects of opioids in people who have taken them, but has no effect on those who have not.
When to interrupt dosage
The advocated dosage of Buprenorphine Hydrochloride is contingent upon the determined condition, including Opioid Dependence, Pain and Septic Shock. The volume of dosage is contingent upon the method of delivery (e.g. Spray, metered or Tablet) detailed in the table below.Condition
Dosage
Administration
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Opioid Dependence
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Warnings
Buprenorphine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Oral Mucositis
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
opioid naive
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Hypocalcemia
Do Not Combine
Hypokalemia
Do Not Combine
Hypomagnesemia
Do Not Combine
Mental Depression
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Long QT Syndrome
Do Not Combine
Common Buprenorphine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Buprenorphine Hydrochloride Toxicity & Overdose RiskIf a person has not taken opioids, naloxone will not have a major impact on them. In mice and rats, the lowest toxic dose when taken orally is greater than 1g/kg. When administered intraperitoneally, the lowest toxic dose is 80mg/kg in mice and 239mg/kg in rats. For subcutaneous administration, the lowest toxic dose is 286mg/kg in mice and 500mg/kg in rats.
Buprenorphine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Buprenorphine Hydrochloride?
64 active clinical trials are currently investigating the potential of Buprenorphine Hydrochloride to alleviate Opioid Dependency, Opioid-Induced Pain, and other Pain Disorders.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Opioid Dependence
14 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Pain
0 Actively Recruiting
Buprenorphine Hydrochloride Reviews: What are patients saying about Buprenorphine Hydrochloride?
5Patient Review
6/4/2018 Buprenorphine completely changed my life for the better. I had been struggling with painkiller addiction for years, and this medication allowed me to get my life back on track. I highly recommend it to anyone who is struggling with a similar problem.
5Patient Review
3/28/2021 This medication has completely changed my life for the better. I was taking hydrocodone, gabapentin, and oxycodone for nerve pain, but this treatment is much more effective with no withdrawals.
5Patient Review
7/4/2022 I've been on Buprenorphine for two months now, and it's by far the best pain medication I've ever tried. Before, my pain would only last for 4 hours before coming back, but now I'm getting 6-8 hours of relief. It's definitely changed my life for the better and I would encourage anyone in chronic pain to give it a try!
5Patient Review
1/28/2020 This medication saved my life. I went off of it for a short period and in time, I was back to narcotics. I ran back to my doctor and asked him to prescribe it again. I plan on being on this until I die. My mood is so much better, even though it doesnâ??t advertise as a mood enhancer.
5Patient Review
9/6/2019 I was a little bit out of it after taking this medication, but it did help with my overall pain.
4Patient Review
2/1/2019 I used this for several years to get off opioids, which I was addicted to. This helped with my chronic back pain. However, a new doctor switched me to methadone, which works MUCH better. Been on methadone for 5 years now and although it is addictive, it too helps with pain and although it can be abused, you learn not to.
3.7Patient Review
6/15/2022 I am only getting minimal relief from this medication, even though I am following the instructions to dissolve it under my tongue.
3.3Patient Review
6/17/2021 I was on opioids for 10 years, and had no issues getting off of them. I changed my pain doctor, but he is too conservative for me. This pill is not effective for me, and maybe a stronger dose would be better. I'm going to give it a week but at this point, I do not recommend this treatment.
2Patient Review
3/10/2020 This was worse than kicking my morphine habit and the withdrawal lasted for weeks.
1.3Patient Review
4/24/2021 This medication failed me not once, but twice in two different years. I was only able to get it a third time because of a change in hospital policy that left patients like me who have been relying on opioids for chronic pain for 19 years out to dry. There is zero relief for people in my position.
1.3Patient Review
9/12/2019 Hard to obtain if you don't have insurance.
Patient Q&A Section about buprenorphine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Buprenorphine Hydrochloride a drug?
"Buprenorphine is a drug used to relieve pain. It was first marketed in the United States in 1985 as a drug with a low potential for abuse."
Answered by AI
What is the drug buprenorphine used for?
"Buprenorphine and the combination of buprenorphine and naloxone can help treat opioid dependence. This is when someone is addicted to drugs like heroin or painkillers."
Answered by AI