Buprenorphine Hydrochloride

Pain, Opioid-Related Disorders, Pain
Treatment
2 FDA approvals
0 Active Studies for Buprenorphine Hydrochloride

What is Buprenorphine Hydrochloride

BuprenorphineThe Generic name of this drug
Treatment SummaryNaloxone is a medication used to reverse the effects of opioid drugs and prevent overdoses. It works by blocking opioid receptors in the brain and stopping opioid drugs from having an effect. Naloxone is commonly known under the brand name Narcan and is available as an injection, nasal spray, or IV infusion. Naloxone is also combined with buprenorphine in the product Suboxone, used to treat opioid addiction. It is very safe to use and has few side effects, but can cause withdrawal symptoms if given to someone taking opioid drugs. Naloxone can be used to save someone’s
Buprenexis the brand name
image of different drug pills on a surface
Buprenorphine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261

Approved as Treatment by the FDA

Buprenorphine, commonly known as Buprenex, is approved by the FDA for 2 uses which include Opioid Dependence and Opioid-Related Disorders .
Opioid Dependence
Used to treat Opioid Dependence in combination with Naloxone
Opioid-Related Disorders
Used to treat Opioid Dependence in combination with Naloxone

Effectiveness

How Buprenorphine Hydrochloride Affects PatientsNaloxone is used to quickly reverse the effects of opioid overdoses. It does not last as long as opioids, so multiple doses may be necessary. Naloxone will not have any effect if no opioids have been taken by the patient. Those given naloxone might experience opioid withdrawal. Additionally, the overdose may not be completely reversed if other drugs are involved.
How Buprenorphine Hydrochloride works in the bodyNaloxone is a drug that prevents opioids from binding to the body's opioid receptors. It works to reverse the effects of opioids in people who have taken them, but has no effect on those who have not.

When to interrupt dosage

The advocated dosage of Buprenorphine Hydrochloride is contingent upon the determined condition, including Opioid Dependence, Pain and Septic Shock. The volume of dosage is contingent upon the method of delivery (e.g. Spray, metered or Tablet) detailed in the table below.
Condition
Dosage
Administration
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Opioid-Related Disorders
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous

Warnings

Buprenorphine Hydrochloride Contraindications
Condition
Risk Level
Notes
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Stomatitis
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
opioid naive
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Hypocalcemia
Do Not Combine
Hypokalemia
Do Not Combine
Hypomagnesemia
Do Not Combine
Mental Depression
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Long QT Syndrome
Do Not Combine
There are 20 known major drug interactions with Buprenorphine Hydrochloride.
Common Buprenorphine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Buprenorphine Hydrochloride Toxicity & Overdose RiskIf a person has not taken opioids, naloxone will not have a major impact on them. In mice and rats, the lowest toxic dose when taken orally is greater than 1g/kg. When administered intraperitoneally, the lowest toxic dose is 80mg/kg in mice and 239mg/kg in rats. For subcutaneous administration, the lowest toxic dose is 286mg/kg in mice and 500mg/kg in rats.
image of a doctor in a lab doing drug, clinical research

Buprenorphine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Buprenorphine Hydrochloride?

64 active clinical trials are currently investigating the potential of Buprenorphine Hydrochloride to alleviate Opioid Dependency, Opioid-Induced Pain, and other Pain Disorders.
Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Opioid-Related Disorders
0 Actively Recruiting

Buprenorphine Hydrochloride Reviews: What are patients saying about Buprenorphine Hydrochloride?

5Patient Review
6/4/2018
Buprenorphine Hydrochloride for Pain
Buprenorphine completely changed my life for the better. I had been struggling with painkiller addiction for years, and this medication allowed me to get my life back on track. I highly recommend it to anyone who is struggling with a similar problem.
5Patient Review
3/28/2021
Buprenorphine Hydrochloride for Pain
This medication has completely changed my life for the better. I was taking hydrocodone, gabapentin, and oxycodone for nerve pain, but this treatment is much more effective with no withdrawals.
5Patient Review
7/4/2022
Buprenorphine Hydrochloride for Chronic Pain
I've been on Buprenorphine for two months now, and it's by far the best pain medication I've ever tried. Before, my pain would only last for 4 hours before coming back, but now I'm getting 6-8 hours of relief. It's definitely changed my life for the better and I would encourage anyone in chronic pain to give it a try!
5Patient Review
1/28/2020
Buprenorphine Hydrochloride for Prevention of Opiate Drug Abuse
This medication saved my life. I went off of it for a short period and in time, I was back to narcotics. I ran back to my doctor and asked him to prescribe it again. I plan on being on this until I die. My mood is so much better, even though it doesnâ??t advertise as a mood enhancer.
5Patient Review
9/6/2019
Buprenorphine Hydrochloride for Chronic Pain
I was a little bit out of it after taking this medication, but it did help with my overall pain.
View All Reviews
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Patient Q&A Section about buprenorphine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Buprenorphine Hydrochloride a drug?

"Buprenorphine is a drug used to relieve pain. It was first marketed in the United States in 1985 as a drug with a low potential for abuse."

Answered by AI

Is Buprenorphine hydrochloride the same as Suboxone?

"Buprenorphine is a medication used to treat opioid dependence or moderate to severe pain. It is not the same as Suboxone, which is a two-ingredient drug used only to treat opioid dependence."

Answered by AI

Is Buprenorphine hydrochloride a narcotic?

"Buprenorphine is an opioid partial agonist, a type of narcotic. It's used in higher doses to treat opioid addiction and dependence, and in lower doses to treat moderate to severe pain."

Answered by AI

What is the drug buprenorphine used for?

"Buprenorphine and the combination of buprenorphine and naloxone can help treat opioid dependence. This is when someone is addicted to drugs like heroin or painkillers."

Answered by AI
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