What is Bunavail
NaloxoneThe Generic name of this drug
Treatment SummaryNaloxone is a medication that blocks or reverses the effects of opioid drugs. It is used to treat drug overdoses caused by opioids such as morphine, hydromorphone, methadone, heroin, and fentanyl. It works by binding to opioid receptors in the body and blocking the effects of other drugs bound to those receptors. Common symptoms of an opioid overdose include trouble breathing, slow heart rate, slurred speech, drowsiness, and constricted pupils. If not treated, this can lead to vomiting, no pulse or breathing, loss of consciousness and even death. Naloxone can be given by intram
Narcanis the brand name
Bunavail Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Narcan
Naloxone
1971
241
Approved as Treatment by the FDA
Naloxone, otherwise called Narcan, is approved by the FDA for 6 uses including Opioids and Pain .Opioids
Pain
Used to treat Severe Pain in combination with Pentazocine
Septic Shock
Opioid Dependence
Used to treat Opioid Dependence in combination with Buprenorphine
Pain
Used to treat moderate Pain in combination with Pentazocine
Respiratory Depression
Effectiveness
How Bunavail Affects PatientsNaloxone is a medication that is used to reverse the effects of an opioid overdose. It works quickly but may need to be taken multiple times. It is safe to take even if the person has not taken opioids, but they may experience withdrawal symptoms. It is important to note that naloxone may not completely fix all symptoms if the person has also taken other drugs.
How Bunavail works in the bodyNaloxone is a drug that blocks the effects of opioids in the body. It binds to the opioid receptors, preventing opioids from binding and blocking their effects. If someone has not taken opioids, naloxone will not have any effect.
When to interrupt dosage
The advised measure of Bunavail is dependent upon the determined condition, including Opioid Dependence, Pain and Septic Shock. The dosage differs, depending on the technique of delivery (e.g. Spray, metered or Tablet) specified in the table below.Condition
Dosage
Administration
Pain
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Opioids
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Respiratory Depression
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Pain
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Itching
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Opioid Dependence
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Septic Shock
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Opioids
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Opioids
4.0 mg, 20.0 mg/mL, 3.0 mg, , 1.0 mg, 4.0 mg/mL, 0.3 mg, 1.0 mg/mL, 0.4 mg/mL, 0.02 mg/mL, 40.0 mg/mL, 0.18 mg, 2.0 mg, 0.4 mg, 1.4 mg, 20.0 mg, 10.0 mg, 5.0 mg, 0.5 mg, 0.71 mg, 2.1 mg, 2.9 mg, 100.0 mg/mL, 0.36 mg, 80.0 mg/mL, 50.0 mg/mL, 2.5 mg, 0.7 mg, 1.8 mg
Spray, metered, Tablet, Intramuscular; Intravenous; Subcutaneous, Film, soluble - Buccal; Sublingual, , Injection, solution - Intramuscular; Subcutaneous, Oral, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Injection, solution, Intramuscular; Subcutaneous, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet - Sublingual, Film, Tablet, extended release - Oral, Solution, Spray, Parenteral, Sublingual, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Spray - Nasal, Buccal, Film, soluble, Spray, metered - Nasal, Nasal, Film, soluble - Sublingual, Injection - Parenteral, Tablet, extended release, Tablet, film coated, extended release, Injection - Intravenous, Injection - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Injection, Film - Buccal; Sublingual, Liquid, Intravenous, Tablet - Oral, Injection; Kit - Parenteral; Topical, Liquid - Intramuscular; Intravenous; Subcutaneous, Buccal; Sublingual, Injection; Kit, Pill, Parenteral; Topical, Inhalant, Inhalant - Nasal
Warnings
Bunavail has one contraindication, so it should not be used when someone experiences any of the conditions listed in the table below.Bunavail ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Naloxone may interact with Toxoplasma Infections
Common Bunavail Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Naloxone.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Naloxone.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Naloxone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Naloxone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Naloxone.
Bunavail Toxicity & Overdose RiskIf a patient hasn't taken opioids, naloxone won't have much of an effect. The toxic dose of naloxone in mice is higher than 1g/kg when taken orally, 80mg/kg when given through the abdomen, and 286mg/kg when given through the skin. The toxic dose in rats is higher than 1g/kg when taken orally, 239mg/kg when given through the abdomen, and 500mg/kg when given through the skin.
Bunavail Novel Uses: Which Conditions Have a Clinical Trial Featuring Bunavail?
64 active trials are being conducted to investigate Bunavail's potential as a therapeutic agent for Opioids, Opioids-Induced Pain and other associated conditions.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Opioids
0 Actively Recruiting
Itching
14 Actively Recruiting
Phase 2, Phase 4, Phase 3, Early Phase 1
Septic Shock
13 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Phase 4
Opioids
1 Actively Recruiting
Early Phase 1
Pain
0 Actively Recruiting
Respiratory Depression
1 Actively Recruiting
Phase 4
Opioids
6 Actively Recruiting
Not Applicable, Phase 4
Opioid Dependence
14 Actively Recruiting
Phase 3, Phase 4, Not Applicable, Phase 2, Phase 1, Early Phase 1
Bunavail Reviews: What are patients saying about Bunavail?
5Patient Review
2/23/2015 I've been addicted to pills and heroin for over a decade, and this is by far the best treatment I've tried. Methadone and suboxone didn't work as well for me, and I find that this treatment doesn't have any horrible after taste or cravings. I'm also using half the amount of suboxone, which is great.
5Patient Review
12/20/2016 I found that this drug absorbed quicker than Suboxone and required less mg to be effective. From reading the negative reviews, it's obvious that these people either didn't give it a chance or aren't actually trying to get better. Bunavail works great for me.
5Patient Review
10/30/2015 Super easy to use and really quick-acting.
3Patient Review
2/26/2015 I wasn't as impressed with this drug as I was with suboxone. It takes a while to work- sometimes up to 45 minutes- and even then I still have to spit it out. Suboxone just seems to do a better job at managing cravings and pain.
2.7Patient Review
12/29/2014 I'm not sure if this drug is effective yet. I took it today for the first time and now I have a headache and feel jittery. I don't want to get addicted to another medication, so I'm going to talk to my doctor about it tomorrow.
2Patient Review
4/2/2016 This product isn't as effective as other bupe products I've tried. It's also bulky and takes a while to dissolve, which makes it less convenient than it could be.
1.7Patient Review
2/12/2017 I have been taking Suboxone for a while, and I was doing well. But then I had to switch to Bunavail, which is not as effective. It wears off quickly and always makes me feel like I'm going through withdrawal.
1.7Patient Review
5/26/2015 This didn't work for me at all. I feel like it took forever to dissolve, and when it finally did, it didn't seem to help at all. My doctor switched me off of this after just a few years; I'll be going back to the old medication next visit.
1Patient Review
8/23/2015 I would not recommend this treatment to anyone. I only tried it because it was free, and I much prefer suboxone over it. It's my third time trying to come off of opioids, and this just doesn't work as well in my opinion.
1Patient Review
10/8/2015 This is a terrible drug. Do not take it. It did nothing to help me with my withdrawal symptoms and made them worse.
1Patient Review
12/21/2014 I'm in total agreement with the last person who reviewed this. It takes forever and there's still some left over. Not to mention, I don't think it works well at all since it doesn't seem to be properly absorbed into my cheek.
1Patient Review
4/28/2017 This medication was a terrible experience. I didn't sleep for four days, had difficulty urinating, it took too long to dissolve, and left chunks in my mouth. On the fifth day, I started vomiting and having debilitating upper stomach pain. The doctor prescribed suboxone instead and it's much more effective without all the horrendous side effects. So grateful for suboxone!
Patient Q&A Section about bunavail
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Bunavail the same as Suboxone?
"The main differences between Bunavail and Suboxone are: -Bunavail is more easily and completely absorbed into the bloodstream. -Suboxone is considered to be approximately twice as strong as Bunavail."
Answered by AI
What is Bunavail buccal film?
"BUNAVAIL is a yellow, rectangular film that is citrus-flavored and is intended to be applied to the buccal mucosa. The film has ink markings on the mucoadhesive side."
Answered by AI
What is Bunavail used for?
"Naloxone blocks the effects of opioids at the opioid receptors, and reverses the respiratory depression caused by buprenorphine.
This medication is a combination of buprenorphine and naloxone, and is used to treat opioid dependence or addiction. Buprenorphine is a drug that belongs to a class of mixed opioid agonist-antagonists, and helps to prevent withdrawal symptoms that can occur when other opioids are stopped. Naloxone is a drug that blocks the effects of opioids at the opioid receptors, and also reverses the respiratory depression that buprenorphine can cause."
Answered by AI
Is Bunavail still available?
"BioDelivery Sciences International, Inc. is discontinuing its drug Bunavail in the United States as of March 2020."
Answered by AI