Bismuth Subsalicylate

Curling Ulcer, Indigestion, Flatulence + 9 more
Treatment
16 FDA approvals
20 Active Studies for Bismuth Subsalicylate

What is Bismuth Subsalicylate

Bismuth subsalicylateThe Generic name of this drug
Treatment SummaryBismuth subsalicylate is a medication used to relieve nausea, diarrhea, and stomach discomfort. It is an antacid and anti-diarrheal agent that has been around for over 100 years and was approved by the FDA in 1939. It is an active ingredient in Pepto-Bismol, an over-the-counter medication, and is also a key component of HELIDAC Therapy, a treatment regimen used to treat patients with an infection of the bacteria H. pylori.
Topcare stomach relief original strengthis the brand name
image of different drug pills on a surface
Bismuth Subsalicylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Topcare stomach relief original strength
Bismuth subsalicylate
1989
4

Approved as Treatment by the FDA

Bismuth subsalicylate, also called Topcare stomach relief original strength, is approved by the FDA for 16 uses such as Flatulence and Gastroenteritis .
Flatulence
Gastroenteritis
Traveler's Diarrhea
Indigestion
Curling Ulcer
Used to treat Duodenal Ulcer in combination with Metronidazole
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Metronidazole
Heartburn
Used to treat Heartburn in combination with Calcium carbonate
Duodenal Ulcer
Used to treat Duodenal Ulcer in combination with Metronidazole
Heartburn
Used to treat Heartburn in combination with Calcium carbonate
Upset stomach
Diarrhea
belching
gastrointestinal fullness
Flatulence
Diarrhea
Gastrointestinal distress

Effectiveness

How Bismuth Subsalicylate Affects PatientsBismuth subsalicylate is a drug with multiple benefits, such as reducing flatulence and diarrhea, relieving gastrointestinal discomfort, and preventing traveler's diarrhea. It also has antimicrobial properties, which can help to fight certain bacteria, including the bacteria that causes stomach ulcers (_Helicobacter pylori_) and other enteric pathogens like _Clostridium difficile_ and _Salmonella_. Bismuth subsalicylate can be used together with other drugs to help treat stomach ulcers.
How Bismuth Subsalicylate works in the bodyBismuth subsalicylate works by breaking down into two substances, salicylic acid and bismuth, in the stomach. The bismuth then binds to other molecules in the stomach to create bismuth salts, which have antimicrobial properties that stop bacteria from sticking to and growing on the stomach's mucosal cells. The salicylic acid acts as an anti-inflammatory, preventing the formation of pro-inflammatory molecules. Bismuth subsalicylate also helps protect the stomach from further damage, and prevents bacteria from performing certain activities like making enzymes. Altogether, these properties help heal ulcers in

When to interrupt dosage

The quantity of Bismuth Subsalicylate is reliant upon the identified disorder, like Nausea, Flatulence and Diarrhea. The amount of dosage is contingent upon the technique of delivery indicated in the table beneath.
Condition
Dosage
Administration
Gastrointestinal distress
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Gastroenteritis
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Diarrhea
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Diarrhea
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
gastrointestinal fullness
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
belching
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Curling Ulcer
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Indigestion
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Upset stomach
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Flatulence
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Helicobacter Pylori Infection
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated
Heartburn
, 52.5 mg/mL, 26.2 mg/mL, 105.0 mg/mL, 262.0 mg, 17.47 mg/mL, 35.0 mg/mL, 2.62 mg/mg, 525.0 mg, 17.5 mg/mL, 300.0 mg, 1.7 %, 524.0 mg, 52.5 mg, 262.4 mg, 17.66 mg/mL, 17.6 mg/mL, 35.2 mg/mL, 23.6 mg/mL, 0.262 mg/mg
Oral, Suspension, Suspension - Oral, , Liquid, Liquid - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Kit, Tablet, film coated - Oral, Tablet, film coated, Kit - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule - Oral, Tablet, coated - Oral, Tablet, coated, Syrup, Syrup - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated

Warnings

Bismuth Subsalicylate Contraindications
Condition
Risk Level
Notes
Stomach Ulcer
Do Not Combine
Blood in Stool
Do Not Combine
Pulse Frequency
Do Not Combine
Melena
Do Not Combine
Fever
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Bismuth Subsalicylate may interact with Pulse Frequency
There are 20 known major drug interactions with Bismuth Subsalicylate.
Common Bismuth Subsalicylate Drug Interactions
Drug Name
Risk Level
Description
Bismuth subcarbonate
Major
Bismuth subsalicylate may increase the neurotoxic activities of Bismuth subcarbonate.
Bismuth subcitrate potassium
Major
Bismuth subsalicylate may increase the neurotoxic activities of Bismuth subcitrate potassium.
Bismuth subgallate
Major
Bismuth subsalicylate may increase the neurotoxic activities of Bismuth subgallate.
Bismuth subnitrate
Major
Bismuth subsalicylate may increase the neurotoxic activities of Bismuth subnitrate.
Probenecid
Major
The therapeutic efficacy of Probenecid can be decreased when used in combination with Bismuth subsalicylate.
Bismuth Subsalicylate Toxicity & Overdose RiskThe lowest toxic dose of bismuth subsalicylate in humans is 700mg/kg. In rats, the toxic dose is 1200mg/kg when taken orally, 542mg/kg when given via intraperitoneal route, and 980mg/kg when given subcutaneously. Taking too much bismuth subsalicylate over a long period of time can cause blackened tongue and teeth, fatigue, changes in mood, mental deterioration, and nerve damage. Other symptoms can include difficulty thinking, shaking, feeling tired, difficulty sleeping, confusion, twitching, seizures, depression, anxiety, and low mood
image of a doctor in a lab doing drug, clinical research

Bismuth Subsalicylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Bismuth Subsalicylate?

68 active research projects are investigating the potential of Bismuth Subsalicylate to regulate Flatulence, Gastrointestinal Fullness and Curling Ulcer.
Condition
Clinical Trials
Trial Phases
Gastroenteritis
12 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Early Phase 1
Curling Ulcer
0 Actively Recruiting
Diarrhea
0 Actively Recruiting
Diarrhea
0 Actively Recruiting
gastrointestinal fullness
0 Actively Recruiting
Helicobacter Pylori Infection
1 Actively Recruiting
Not Applicable
Indigestion
7 Actively Recruiting
Phase 3, Early Phase 1, Phase 2, Not Applicable, Phase 4
Flatulence
0 Actively Recruiting
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Upset stomach
0 Actively Recruiting
belching
0 Actively Recruiting
Gastrointestinal distress
7 Actively Recruiting
Phase 2, Phase 1, Phase 3, Early Phase 1, Not Applicable

Bismuth Subsalicylate Reviews: What are patients saying about Bismuth Subsalicylate?

5Patient Review
5/25/2012
Bismuth Subsalicylate for Indigestion
I had gastric bypass surgery six years ago and I still have trouble digesting my food. This medication has helped me be able to eat, but now my tongue is black. I'm not comfortable with this because it's not a temporary side effect; I have to take the medication every time I eat. I don't want to walk around with a black tongue for the rest of my life.
5Patient Review
10/14/2013
Bismuth Subsalicylate for Diarrhea
After trying reglan and diociline without success, I decided to just take this medication myself. The results were almost instantaneous and very impressive.
5Patient Review
4/18/2009
Bismuth Subsalicylate for Diarrhea
4.7Patient Review
5/11/2016
Bismuth Subsalicylate for Diarrhea
My doctor recommended this for my colitis-related diarrhea, and it's been working great! I take it three times a day when I'm having issues, and it's really helped. Of course, I still have to be careful about what I eat, but this has made a big difference.
2.7Patient Review
9/8/2010
Bismuth Subsalicylate for Indigestion
Pepto-Bismol has been a game changer for me. I take two pills in the morning and two in the evening, as per my doctor's orders, and I haven't felt this good in over 20 years.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bismuth subsalicylate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should not take bismuth subsalicylate?

"This product is not recommended for children or teens under the age of 18 who have chickenpox, the flu, or any undiagnosed illness, or who have recently received a vaccine. Taking aspirin or aspirin-like products in these cases increases the risk of developing Reye's syndrome, a rare but serious illness."

Answered by AI

Is bismuth subsalicylate the same as Pepto-Bismol?

"The brand name for bismuth subsalicylate is Pepto-Bismol. Bismuth has antimicrobial effects against certain bacteria that cause diarrhea, while subsalicylate has antisecretory effects against fluid and electrolyte loss. Bismuth subsalicylate also has anti-inflammatory actions on the stomach and intestinal lining."

Answered by AI

When should you take bismuth subsalicylate?

"For diarrhea or upset stomach:

Adults and teenagers should take 2 tablets every half hour to one hour. You should not take more than 16 tablets in twenty-four hours. Children should not use this medication."

Answered by AI

Does bismuth subsalicylate have side effects?

"Side effects of bismuth subsalicylate can include changes in behaviour, nausea and vomiting, hearing loss or ringing in the ears, diarrhoea lasting longer than 2 days, or worsening of stomach symptoms."

Answered by AI

Clinical Trials for Bismuth Subsalicylate

Have you considered Bismuth Subsalicylate clinical trials? We made a collection of clinical trials featuring Bismuth Subsalicylate, we think they might fit your search criteria.
Have you considered Bismuth Subsalicylate clinical trials? We made a collection of clinical trials featuring Bismuth Subsalicylate, we think they might fit your search criteria.
Have you considered Bismuth Subsalicylate clinical trials? We made a collection of clinical trials featuring Bismuth Subsalicylate, we think they might fit your search criteria.
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