Postbiotic for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests an oral postbiotic supplement to assess its effects on metabolic health in overweight adults. Participants will take either a postbiotic supplement or a placebo (a pill with no active ingredients) daily. It suits adults with a body mass index (BMI) between 25 and 40 who do not smoke or have major health issues like heart or liver problems. Participants must maintain their usual diet and exercise habits and avoid other supplements.
As an unphased trial, this study allows participants to contribute to groundbreaking research in metabolic health.
Do I have to stop taking my current medications for the trial?
The trial information does not specify if you need to stop taking your current medications. However, you must avoid other probiotic and postbiotic supplements during the study.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that postbiotics are usually safe for people to use. Studies suggest that postbiotics can help with metabolism and weight issues without causing major side effects. One review pointed out that postbiotics are a safe choice and can help reduce fat growth while increasing energy use. So far, these findings indicate that taking postbiotics is safe for humans, with no serious negative effects reported.12345
Why are researchers excited about this trial's treatment?
Unlike the standard treatments for obesity, which often include lifestyle changes, medications like orlistat, or surgical options, the postbiotic supplement under study offers a novel approach. This treatment is unique because it combines a postbiotic with a herbal blend and vitamins, taken in a simple daily capsule. Researchers are particularly excited about its potential to influence gut health and metabolism through postbiotics, which are non-living bacterial products or byproducts. This mechanism could offer a new way to support weight management by enhancing gut microbiota balance, which is a different angle from current options that primarily focus on appetite suppression or fat absorption.
What evidence suggests that this postbiotic might be an effective treatment for obesity?
This trial will compare a postbiotic supplement with a placebo to evaluate its effects on obesity. Research has shown that postbiotics might aid in obesity management. Studies suggest they can lead to an average weight loss of about 9 grams. They also appear to reduce the formation of new fat cells and increase the body's energy expenditure. Additionally, postbiotics may improve sugar metabolism by enhancing insulin sensitivity and reducing inflammation. These factors are important for managing obesity. Overall, postbiotics are considered a safe and potentially effective option for weight management.12467
Who Is on the Research Team?
Ahmed Abdelgawad, MD
Principal Investigator
Able Biolabs, LLC
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 with a BMI of 25.0-40.0, who are in good health and willing to maintain their current diet and exercise routines. Participants must not use other probiotic or postbiotic supplements during the study and should be able to follow the study protocol.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either a placebo or the postbiotic supplement daily to evaluate its impact on weight loss and metabolic health
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Postbiotic
Trial Overview
The trial is testing an oral postbiotic supplement's effect on metabolic health in overweight individuals compared to a placebo. The goal is to see if this supplement can support weight loss and improve metabolic markers.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
1 capsule of 40 mg postbiotic, 450 mg herbal blend, and 810 mcg vitamins taken once daily
1 capsule of placebo, taken once daily
Find a Clinic Near You
Who Is Running the Clinical Trial?
ResBiotic Nutrition, Inc.
Lead Sponsor
Able Biolabs, LLC
Collaborator
Citations
Postbiotics against Obesity: Perception and Overview Based ...
Postbiotics have been reported to have significant potential in alleviating obesity. This review comprehensively discusses the anti-obesity ...
2.
translational-medicine.biomedcentral.com
translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06927-zPostbiotics as a novel intervention for obesity management ...
Generally, the findings of this meta-analysis showed that supplementation with different postbiotics results in a 9g decrease in body weight and ...
The anti-obesity effects of postbiotics: A systematic review ...
Postbiotics seem to be a safe intervention and the results were in favor of a reduction in adipogenesis as well as an increase in energy expenditure. Further ...
Incorporating Postbiotics into Intervention for Managing ...
Preclinical studies suggest that postbiotics can modulate adipogenesis, improve insulin sensitivity, and reduce systemic inflammation—all key factors in the ...
Postbiotics for the management of obesity, insulin ...
In conclusion, the available scientific data indicate that postbiotic administration not only is safer, but also as effective as probiotic ...
NCT06911073 | A Study to Evaluate a Postbiotic in ...
This study aims to evaluate the impact of a specific oral postbiotic supplement on metabolic health in overweight adults.
Efficacy and safety of postbiotic supplementation in ...
In the placebo group, a decreasing trend in BMI and weight was observed. In parallel, intervention with placebo was associated with a significant decrease in ...
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