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What is Azilect
RasagilineThe Generic name of this drug
Treatment SummaryRasagiline is a medication used to treat Parkinson’s disease. It works by blocking an enzyme called monoamine oxidase, which helps control the body’s levels of certain neurotransmitters. It can be used on its own to treat early stages of Parkinson’s or in combination with other medications to treat more advanced cases.
Azilectis the brand name
Azilect Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Azilect
Rasagiline
2006
22
Approved as Treatment by the FDA
Rasagiline, also known as Azilect, is approved by the FDA for 1 uses like Parkinson's Disease .Parkinson's Disease
Effectiveness
How Azilect Affects PatientsRasagiline is a medicine that works by blocking an enzyme called monoamine oxidase (MAO). MAO helps break down certain hormones and chemicals, like serotonin and dopamine, in the body. Rasagiline only affects MAO-B, which is the major form of MAO in the brain. It has been shown to be a powerful and irreversible inhibitor of MAO-B in animal studies. At recommended doses, it is also a powerful inhibitor of MAO-B in platelets. While its selectivity for MAO-B means that it is unlikely to cause interactions with dietary tyramine
How Azilect works in the bodyThe exact way rasagiline works is unknown, but it is thought to be related to its ability to block an enzyme called monoamine oxidase B. This enzyme blocks dopamine, a brain chemical that helps control movement. When rasagiline blocks this enzyme, the dopamine levels in the brain increase, which helps improve motor function.
When to interrupt dosage
The suggested dosage of Azilect is contingent on the diagnosed state. The quantity of dosage fluctuates as per the technique of delivery specified in the table beneath.Condition
Dosage
Administration
Parkinson's Disease
, 1.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Azilect.Common Azilect Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
Rasagiline may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
Rasagiline may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
Rasagiline may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
Major
Rasagiline may increase the hypertensive activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Rasagiline.
Azilect Toxicity & Overdose RiskSigns of overdosing on this drug may include drowsiness, dizziness, confusion, restlessness, severe headache, hallucinations, stiffening of the body, seizures, or falling into a coma. Other symptoms can include an irregular or rapid pulse, changes in blood pressure, chest pain, difficulty breathing, extreme body temperature, sweating, and cold and clammy skin.
Azilect Novel Uses: Which Conditions Have a Clinical Trial Featuring Azilect?
45 active clinical trials are presently investigating the potential of Azilect to ameliorate degenerative conditions such as Parkinson's Disease.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Azilect Reviews: What are patients saying about Azilect?
5Patient Review
2/8/2017 Azilect has been a godsend for me. I was struggling immensely with my symptoms before starting this medication, but now I barely have any motor symptoms at all. It's worked wonders for me, and I'm so grateful to my doctor for prescribing it.
5Patient Review
6/25/2017 I had DBS surgery in 2014 and have been using this medication alongside amantadine since then. I haven't experienced any negative side effects, but it is quite pricey.
4.7Patient Review
9/6/2013 It's been about a month and a half since I started taking Azilect, and while there hasn't been a significant change in my symptoms, I have had some nights where I wake up feeling extremely anxious and jittery. Not sure if this is related to the medication or not, but it's certainly something to keep an eye on. Also unsure as to what foods I should avoid while taking this medication.
4.7Patient Review
11/10/2015 Azilect has been an effective treatment for me in managing my Parkinson's Disease. I've seen the disease progress much more quickly in those who haven't taken this medication, and I believe it has helped me to maintain a good quality of life.
4.3Patient Review
11/19/2013 I was diagnosed with Parkinson's Disease a little over 2 1/2 years ago and placed on azilect about 1 1/2 years ago. I have not noticed any significant decrease in tremors, but it has not gotten worse either. I believe that regular exercise is helping more than the medication.
4.3Patient Review
10/13/2013 I occasionally feel a tightness in my upper back and shoulders after taking this medication. It's not terribly discomforting, but it is noticeable.
4.3Patient Review
7/2/2013 I am taking Selegiline HCL 5 MG because Azilect wasn't covered by insurance. So far it's been working quite well, no significant complaints.
4.3Patient Review
10/4/2013 I've been using this medication for about nine months to help with my hand tremor. It's been effective in that it hasn't gotten worse, and I haven't experienced any negative side effects.
4Patient Review
12/17/2013 I was diagnosed early and have been taking Azilect for a year now. I printed out a list of foods to avoid while taking the medication and that has helped me a lot. I'm still able to work three days a week and I'm grateful for my loving family.
4Patient Review
10/28/2015 I get my medication for a very cheap price from a Canadian pharmacy, and the quality is just as good. I've had minimal side effects too.
4Patient Review
6/29/20133.7Patient Review
4/18/2014 It's hard to tell if this treatment is working because Parkinson's disease is a progressive disorder.
2.3Patient Review
6/7/2016 I have early-stage Parkinson's and was given the choice to stop my Levodopa medication in favor of trying Azilect. I stopped taking Levodopa, waited two days, then started on Azilect. After two weeks of being on Azilect, my PD symptoms are worse; I have less control, am experiencing low-grade headaches (I never had headaches before), and my blood pressure is elevated. I'm going to give it two more days to see if these are indeed side effects of the medication, but as of right now I plan to discontinue use.
2.3Patient Review
3/1/2014 I've been taking Azilect for three years alongside Sinemet and Ropinirole. My PD symptoms have neither worsened nor improved, which is disappointing. However, the side effects warnings are becoming increasingly alarming, and I experienced some of them myself such as neck soreness/stiffness, lightheadedness, tingling, one-sided weakness, and itching. With so much uncertainty surrounding this drug, I stopped taking it.
1.7Patient Review
2/23/2015 I'm not entirely sure what this medication is supposed to help with, and it's quite expensive.
1Patient Review
6/27/2015 I had a really severe reaction to this medication, including hives. My doctor said that I should go back on it after a few days, but there's no way I'm taking that chance again.
Patient Q&A Section about azilect
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Azilect?
"The following side effects may occur: dizziness, drowsiness, joint pain, heartburn, nausea, dry mouth, weight loss, or stomach/abdominal pain. To reduce the risk of dizziness and lightheadedness, slowly get up when rising from a sitting or lying position, especially when you first start taking rasagiline."
Answered by AI
When should I take Azilect?
"It is best to take the tablets at the same time each day to help you remember. You can take them before or after meals. If you forget a dose, take it as soon as you remember. If you don't remember until the next day, skip the missed dose."
Answered by AI
What foods should be avoided when taking Azilect?
"MAO-B inhibitors like Azilect (rasagiline) and Eldepryl (selegeline) should avoid foods with tyramine. This includes cured, fermented or air-dried meats or fish, aged cheeses, fermented cabbage, soybean products, and red wine and tap beer. Eating these foods while taking MAO-B inhibitors can lead to high blood pressure."
Answered by AI
What does Azilect do for Parkinsons?
"Azilect is a medication used to treat [Parkinson's disease](https://www.withpower.com/clinical-trials/parkinson's-disease). It works by reducing the breakdown of dopamine in the brain. Dopamine is a chemical that sends signals to the parts of the brain that control movement and coordination. In the early stages of Parkinson's disease, Azilect can be used as a single drug to slow the progression of symptoms."
Answered by AI