Astelin

Blepharitis allergic, Rhinitis, Vasomotor, Hay Fever + 6 more
Treatment
2 Active Studies for Astelin

What is Astelin

AzelastineThe Generic name of this drug
Treatment SummaryAzelastine is a medication used to treat allergies and nasal congestion. It comes in the form of an intranasal spray and an ophthalmic solution. Azelastine was approved by the FDA in 1996 and is sometimes combined with fluticasone propionate as a nasal spray called Dymista, which is used to treat seasonal allergies in people 6 years and older.
Astelinis the brand name
image of different drug pills on a surface
Astelin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Astelin
Azelastine
1996
56

Effectiveness

How Astelin Affects PatientsAzelastine works by blocking the effects of histamine, which helps relieve allergy symptoms. The effects of this drug can be felt as quickly as 15 minutes after taking intranasal formulations or 3 minutes after taking ophthalmic solutions. Taking intranasal formulations produces peak effects 4-6 hours after the initial dose, and these effects are maintained for 12 hours.
How Astelin works in the bodyAzelastine is a medication used to relieve the symptoms of allergies. It works by blocking histamine H1-receptors, which are located on nerve endings, smooth muscle cells, and glandular cells. When allergens enter the body, they trigger mast cells to release histamine. This histamine binds to the H1-receptors and causes typical allergic symptoms like itching and sneezing. Azelastine also works by stabilizing mast cells and preventing them from releasing other substances like interleukin-6 and leukotrienes that can cause further allergic reactions. It also reduces the amount of

When to interrupt dosage

The prescribed measure of Astelin is contingent upon the identified condition, including Hay Fever, Disorder of eye and Keratoconjunctivitis. The dose of the medication is contingent upon the delivery procedure (e.g. Nasal or Solution / drops) featured in the table beneath.
Condition
Dosage
Administration
Keratoconjunctivitis
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Administration, Intranasal
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
allergic eye disorders
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Rhinitis, Vasomotor
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Blepharitis allergic
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Rhinitis, Allergic
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Allergy to Tree Pollen
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Hay Fever
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Allergic Conjunctivitis (AC)
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic

Warnings

There are 20 known major drug interactions with Astelin.
Common Astelin Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Azelastine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Azelastine.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Azelastine.
Astelin Toxicity & Overdose RiskOverdosing on azelastine can cause drowsiness and should be kept away from children, as it can lead to serious adverse effects. The lowest dose of azelastine that was toxic to rats was 580mg/kg. If overdose occurs, general supportive care should be provided.
image of a doctor in a lab doing drug, clinical research

Astelin Novel Uses: Which Conditions Have a Clinical Trial Featuring Astelin?

There are 9 ongoing clinical trials examining the potential of Intranasal Administration of Astelin in treating Disorders of the Eye and Allergic Blepharitis.
Condition
Clinical Trials
Trial Phases
Rhinitis, Vasomotor
0 Actively Recruiting
Administration, Intranasal
0 Actively Recruiting
Keratoconjunctivitis
0 Actively Recruiting
Hay Fever
0 Actively Recruiting
Allergy to Tree Pollen
0 Actively Recruiting
Allergic Conjunctivitis (AC)
2 Actively Recruiting
Phase 3
Rhinitis, Allergic
0 Actively Recruiting
allergic eye disorders
0 Actively Recruiting
Blepharitis allergic
0 Actively Recruiting

Astelin Reviews: What are patients saying about Astelin?

5Patient Review
3/27/2013
Astelin for Inflammation of the Nose due to an Allergy
I've tried a lot of different treatments over the years, and this is still the best one that gives me relief. I mostly use it at night because it makes me drowsy, but if I drink coffee in the morning I can stave off the sleepiness long enough to get through my day.
5Patient Review
1/21/2012
Astelin for Inflammation of the Nose due to an Allergy
This stuff is awesome.
5Patient Review
4/18/2012
Astelin for Vasomotor Rhinitis
After a bad case of fluid buildup, I lost over 50 lbs but my sinuses went out of control. This has been the best medication I've tried yet for my sinus problems.
4.7Patient Review
9/4/2015
Astelin for Inflammation of the Nose due to an Allergy
I am using this medication in conjunction with Flonase and am seeing good results.
4Patient Review
3/26/2017
Astelin for Non-Seasonal Allergic Runny Nose
This is the most effective nasal spray I've tried, and it doesn't have any of the negative long-term effects that other treatments do.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about astelin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Astelin used for?

"This medication reduces nasal symptoms such as runny/itching/stuffy nose, sneezing, and post-nasal drip caused by allergies or other conditions. Azelastine is an antihistamine."

Answered by AI

Is azelastine the same as Flonase?

"No, azelastine (nasal) is not the same as Flonase. Azelastine (nasal) is an antihistamine medication while Flonase contains a steroid (fluticasone)."

Answered by AI

Is Astelin nasal spray a steroid?

"Azelastine nasal spray is a non-steroidal treatment and has some advantages over intranasal corticosteroids in the treatment of SAR even though its anti-inflammatory effect is not as strong."

Answered by AI

Is Astelin nasal spray safe?

"Azalestime Hydrochloride is an effective and safe antihistamine that can be administered nasally to treat perennial and seasonal allergic rhinitis."

Answered by AI

Clinical Trials for Astelin

Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top