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What is Ancobon
FlucytosineThe Generic name of this drug
Treatment SummaryFlucytosine is a medication used to treat fungal infections. It is a type of analog, meaning it is a compound with a similar structure to the naturally occurring chemical cytosine.
Ancobonis the brand name
Ancobon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ancobon
Flucytosine
1971
38
Approved as Treatment by the FDA
Flucytosine, also called Ancobon, is approved by the FDA for 8 uses which include Urinary tract infection and Septicemia .Urinary tract infection
Septicemia
Yeast Infection
Endocarditis
Cryptococcosis
Meningitis, Fungal
Candidiasis, Systemic
Used to treat Candidiasis, Systemic in combination with Amphotericin B
disseminated Cryptococcosis
Used to treat disseminated Cryptococcosis in combination with Amphotericin B
Effectiveness
How Ancobon Affects PatientsFlucytosine is a medicine that works against certain types of fungus. It enters the fungal cells and is changed into a substance called 5-fluorouracil. This substance stops the fungal cells from making DNA and RNA, which causes them to die. Flucytosine also works better when combined with certain other antifungal drugs, like amphotericin B.
How Ancobon works in the bodyFlucytosine works by preventing fungi from taking in important molecules they need to survive. It also changes the molecules inside the fungi so they can't create DNA or RNA. Ultimately, this leads to the fungi dying off.
When to interrupt dosage
The amount of Ancobon is contingent upon the determined condition, for instance Urinary tract infection, Cryptococcosis and Infections, Fungal. The dosage depends on the method of administration specified in the table below.Condition
Dosage
Administration
Yeast Infection
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
disseminated Cryptococcosis
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Septicemia
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Candidiasis, Systemic
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Meningitis, Fungal
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Cryptococcosis
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Urinary tract infection
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Endocarditis
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Warnings
There are 20 known major drug interactions with Ancobon.Common Ancobon Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with Acteoside.
Ancobon Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats has been found to be greater than 15 gm/kg.
Ancobon Novel Uses: Which Conditions Have a Clinical Trial Featuring Ancobon?
Seven active studies are assessing the potential of Ancobon to treat Endocarditis, Meningitis, Fungal and Yeast Infections.Condition
Clinical Trials
Trial Phases
Septicemia
1 Actively Recruiting
Not Applicable
Candidiasis, Systemic
0 Actively Recruiting
Cryptococcosis
0 Actively Recruiting
disseminated Cryptococcosis
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Endocarditis
0 Actively Recruiting
Yeast Infection
6 Actively Recruiting
Phase 1, Phase 2, Phase 3, Early Phase 1, Not Applicable
Meningitis, Fungal
0 Actively Recruiting
Ancobon Reviews: What are patients saying about Ancobon?
2Patient Review
11/17/2008 I am currently taking this medication.
Patient Q&A Section about ancobon
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class is flucytosine?
"This drug is used to treat serious fungal infections. It is in a class of drugs called antifungals."
Answered by AI
What is flucytosine used for?
"Flucytosine is an antimetabolite used to manage and treat systemic candida and cryptococcus infections. It interferes with fungal metabolism and is effective against a range of fungal infections."
Answered by AI
What is Ancobon used for?
"Ancobon is a generic antifungal medication used to treat serious fungal infections in different parts of the body, including the blood, lungs, heart, central nervous system, and urinary tract."
Answered by AI
How is flucytosine administered?
"Flucytosine can be taken orally or through injection. Some common side effects include suppression of the bone marrow, loss of appetite, diarrhea, vomiting, and psychosis. Allergic reactions, such as anaphylaxis, can also occur."
Answered by AI