Amturnide

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Artery Disease (CAD) + 13 more
Treatment
4 FDA approvals
20 Active Studies for Amturnide

What is Amturnide

AmlodipineThe Generic name of this drug
Treatment SummaryAliskiren is a medication used to treat high blood pressure. It was first approved by the FDA in 2007 and was the first drug of its kind. Studies have found that aliskiren is effective at reducing blood pressure when taken alone or with other blood pressure medications.
Norvascis the brand name
Amturnide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 4 uses like Coronary Artery Disease (CAD) and angiographically documented disease .
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
angiographically documented disease
Used to treat angiographically documented disease in combination with Atorvastatin
Chronic Stable Angina Pectoris
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin

Effectiveness

How Amturnide Affects PatientsAliskiren works by blocking the enzyme renin, which helps to reduce blood pressure. This lowers the risk of serious cardiovascular events like stroke and heart attack.
How Amturnide works in the bodyAliskiren is a drug that helps to lower blood pressure. It works by blocking an enzyme called renin, which is released by the kidneys when they sense that the blood volume is low. Renin usually starts a chain reaction in the body by breaking down a protein called angiotensinogen into angiotensin I, which is then converted to angiotensin II. Angiotensin II is a powerful chemical that causes blood vessels to narrow, raising blood pressure. It also causes your body to release certain hormones that help increase blood pressure even more. By blocking renin, Aliskiren stops this chain reaction from

When to interrupt dosage

The proposed amount of Amturnide is contingent upon the determined state. The measure of dosage fluctuates as per the technique of administration (e.g. Oral or Tablet, film coated) featured in the table beneath.
Condition
Dosage
Administration
angiographically documented disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease (CAD)
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Chronic Stable Angina Pectoris
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Mixed Dyslipidaemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension

Warnings

Amturnide Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Amturnide.
Common Amturnide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Amturnide Toxicity & Overdose RiskThe lowest toxic dose of aliskiren in rats is greater than 2000mg/kg. If someone overdoses on aliskiren, they may experience low blood pressure, which can be treated with supportive care.
image of a doctor in a lab doing drug, clinical research

Amturnide Novel Uses: Which Conditions Have a Clinical Trial Featuring Amturnide?

18 active trials are currently assessing the potential of Amturnide to alleviate Hypertensive disease.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Mixed Dyslipidaemia
0 Actively Recruiting
Congestive Heart Failure
313 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Vasospastic Angina
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Pharmacotherapy
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Hypertensive disease
2 Actively Recruiting
Not Applicable
inadequate response to diet
0 Actively Recruiting
angiographically documented disease
0 Actively Recruiting
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Lifestyle Modification
1 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable

Amturnide Reviews: What are patients saying about Amturnide?

4.3Patient Review
1/15/2013
Amturnide for High Blood Pressure
While this medication was effective, the swelling it caused in my legs was really uncomfortable. It's also not easy to find at the pharmacy, so I have to order it ahead of time.
4Patient Review
12/16/2011
Amturnide for High Blood Pressure
This medication has helped stabilize my pressure but i noticed muscle soreness in my legs and sort of heart throbbing to where it seems as though the ground or surface is shaking below me.
4Patient Review
8/31/2011
Amturnide for High Blood Pressure
2.7Patient Review
3/1/2012
Amturnide for High Blood Pressure
My blood pressure is good, but I suffer from very dry eyes. They burn by the end of the day, and I had severe stomach pains for the first week or two.
2.7Patient Review
11/8/2012
Amturnide for High Blood Pressure
Unfortunately, this caused me headaches and dizziness.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about amturnide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the medication amlodipine used for?

"UK

Amlodipine is a medicine that is used to treat high blood pressure."

Answered by AI

Why was Amturnide discontinued?

"No one treated with Amturnide had to stop taking it because their potassium levels increased or decreased."

Answered by AI

What is Amturnide used for?

"The drug Amturnide is a combination of three drugs - aliskiren, amlodipine, and hydrochlorothiazide. It is used to treat hypertension, or high blood pressure."

Answered by AI

What class of Drug is amlodipine?

"Amlodipine belongs to a group of medications called calcium channel blockers. These drugs work by relaxing the blood vessels, which lowers blood pressure and makes it easier for the heart to pump blood."

Answered by AI

Clinical Trials for Amturnide

Have you considered Amturnide clinical trials? We made a collection of clinical trials featuring Amturnide, we think they might fit your search criteria.
Have you considered Amturnide clinical trials? We made a collection of clinical trials featuring Amturnide, we think they might fit your search criteria.
Have you considered Amturnide clinical trials? We made a collection of clinical trials featuring Amturnide, we think they might fit your search criteria.