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Letrozole + Simvastatin for Breast Cancer
Study Summary
This trial is testing whether adding simvastatin to letrozole may stop the growth of cancer cells more effectively than letrozole alone.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2018 Phase 4 trial • 79 Patients • NCT02137538Trial Design
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Who is running the clinical trial?
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- I do not have any unmanaged ongoing illnesses.I do not have any active liver disease.I am 18 years old or older.I am a woman who has gone through menopause.My kidney function is within the required range.My cancer is HER2 negative based on specific tests.I have had both of my ovaries surgically removed.I am not taking strong CYP3A4 inhibitors, cyclosporine, danazol, or gemfibrozil.I haven't taken part in any other clinical trials within the last 3 months.I haven't taken statins, fibrates, or ezetimibe in the last 3 months.I haven't had any systemic therapy in the last 3 months.My breast cancer is hormone receptor positive and HER2 negative.My cancer is positive for estrogen or progesterone receptors.I have had serious heart problems in the last 3 months.I can take care of myself and am up and about more than half of my waking hours.I have another cancer that is getting worse or needs treatment.
- Group 1: Arm I (letrozole, simvastatin)
- Group 2: Arm II (letrozole)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what extent is the participant pool for this research study?
"Confirmed. According to clinicaltrials.gov, this trial was first published on September 2nd 2022 and has been actively seeking participants ever since; the most recent update being November 21st 2022. Altogether, 40 subjects are needed between 3 sites for data collection purposes."
Is enrollment presently open for this research study?
"That is correct. The information shared on clinicaltrials.gov affirms that this research project, which was initially published on September 2nd 2022, is actively enrolling patients. A total of 40 participants are to be recruited from 3 distinct medical facilities."
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