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What is Ampyra
DalfampridineThe Generic name of this drug
Treatment SummaryDalfampridine is a medication used to improve walking ability in people with multiple sclerosis. It works by blocking certain potassium channels in the body. It was the first drug of its kind to receive FDA approval in 2010 and is specifically designed to help people with multiple sclerosis to move more easily.
Ampyrais the brand name
Ampyra Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ampyra
Dalfampridine
2010
13
Approved as Treatment by the FDA
Dalfampridine, also known as Ampyra, is approved by the FDA for 1 uses including Multiple Sclerosis .Multiple Sclerosis
Helps manage Multiple Sclerosis
Effectiveness
How Ampyra Affects PatientsDalfampridine is a drug that binds to and blocks certain potassium channels in the central nervous system (CNS). It is used mainly to treat multiple sclerosis (MS). It does not cause an irregular heartbeat.
How Ampyra works in the bodyIn Multiple Sclerosis (MS), nerve cells in the brain and spinal cord become unable to function properly. This is usually caused by a loss of the protective coating (myelin) around the nerves. Dalfampridine helps by reducing a leak of potassium ions from these nerves. This helps to restore the normal electric current needed for the nerves to send signals. It also helps to unblock any conduction blocks in demyelinated axons, making it easier for the signals to travel.
When to interrupt dosage
The advised measure of Ampyra is contingent on the diagnosed condition. The quantity of dosage also varies as per the technique of administration (e.g. Tablet, extended release - Oral or Tablet, film coated, extended release) indicated in the table underneath.Condition
Dosage
Administration
Multiple Sclerosis
, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Ampyra has two contraindications which should be avoided if you are dealing with any of the conditions outlined in the table below.Ampyra ContraindicationsCondition
Risk Level
Notes
History of Seizures
Do Not Combine
moderate to severe renal dysfunction
Do Not Combine
Common Ampyra Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
Dalfampridine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Dalfampridine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Dalfampridine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Dalfampridine may decrease the excretion rate of Almasilate which could result in a higher serum level.
Ammonium chloride
Minor
Dalfampridine may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Ampyra Toxicity & Overdose RiskThe toxic dose of the drug for a mouse is 19mg/kg and 21mg/kg for a rat.
Ampyra Novel Uses: Which Conditions Have a Clinical Trial Featuring Ampyra?
At present, there are 193 active trials investigating the potential of Ampyra to improve the symptoms of Multiple Sclerosis.Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
194 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Ampyra Reviews: What are patients saying about Ampyra?
5Patient Review
8/10/2014 I've been on this medication for a year now, and it hasn't done anything to improve my mobility. In fact, I'm not walking at all right now.
5Patient Review
9/16/2016 I've only been on Ampyra for a week and I'm already seeing big changes. My legs feel stronger and I can walk around more easily. I didn't have any major side effects, just some burning sensation in my legs for the first few days. This medication is really helping me manage my condition and I couldn't be happier with it.
4.7Patient Review
4/25/2015 I've seen a significant improvement in my quality of life since starting this medication. I can move around and balance much better than before. Granted, I still have MS symptoms but they're more manageable now. This drug has made a big difference for me!
4.7Patient Review
3/27/2014 I took this for two weeks in an effort to avoid getting a UTI, but unfortunately it didn't work for me. I saw no benefits while taking it.
4Patient Review
2/28/2022 Since being diagnosed with MS in 2011, I've struggled with balance and coordination issues. Ampyra has really helped improve my walking speed and distance, as well as my overall balance. It's not a miracle cure, but it has definitely made a big difference in my quality of life.
3Patient Review
9/12/2020 I was experiencing some serious pain in my lower back and tailbone area, but since I stopped taking Ampyra I haven't had any more problems.
2.7Patient Review
5/20/2019 I found that this drug raises my A1C levels significantly, to the point where I become diabetic. This is apparently a common side effect for women taking this medication, and I wish I had been warned about it beforehand.
2.7Patient Review
2/26/2017 After six weeks of use, I don't believe the benefits justify the costs.
2.7Patient Review
12/7/2013 This didn't help me at all and was a waste of money.
2.3Patient Review
3/5/2014 After 15 days of taking Amprya, I decided to stop. The side effects were: 1) a major hot flash about an hour and a half after taking the drug, 2) feeling very sleepy and sleeping for three hours about two hours after taking the drug, 3) by day five, my gait (the way I walk) and balance got worse, 4) by day eight, I felt very spacey and like my head wasn't connected to my body. These side effects got worse and intensified the problems with my balance and gait. After seven days off the medication, I am back to where I was before starting
2.3Patient Review
1/8/2014 I'm experiencing really bad burning sensations on my skin, like a severe sunburn. I don't know if it's from the Ampyra or not, but I started to notice it after beginning treatment. It's been so bad that I want to stop taking the medication, but I'm waiting for my doctor's appointment first.
2.3Patient Review
6/6/2015 I saw no improvement after two weeks of taking this medication and, in fact, felt worse. This was a major setback for me.
2Patient Review
7/25/2014 After a month on this medication, I noticed an improvement in my ability to walk. However, I started experiencing pain in my mouth when eating spicy foods. This soon progressed to general pain and discomfort that made it difficult to eat or brush my teeth.
2Patient Review
2/10/2018 My wife had a seizure while taking this medication and she almost died in a car accident because of it. Once she stopped taking the medication, she didn't have any more seizures.
2Patient Review
12/1/20131.7Patient Review
7/18/2014 The medication does help me walk more regularly, but I can't overdo it. If I stop taking it, I have a lot of trouble walking again--not sure if that's a side effect or what.
1.3Patient Review
2/7/2015 This medication made my legs burn so badly that I could only take it for three days. It also didn't improve my walking, and may have even made it worse.
Patient Q&A Section about ampyra
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Ampyra used for?
"AMPYRA is a brand prescription medicine that is indicated to help improve walking in adults with multiple sclerosis. This medicine increase walking speed."
Answered by AI
Can Ampyra make MS worse?
"Dalfampridine is a medication that helps improve mobility. It is not intended to prevent symptoms from getting worse or change the course of the disease, but rather to help with walking."
Answered by AI
How does Ampyra help with walking?
"This was demonstrated by an increase in walking speed. These illustrations explain how AMPYRA works by enhancing message conduction in damaged nerve fibers, though the exact process is not fully understood."
Answered by AI
How long does it take for Ampyra to work?
"Some patients who take AMPYRA notice an improvement in their walking ability within a couple of weeks, while others may notice an improvement up to 6 weeks after starting the medication. However, AMPYRA does not work for everyone, and people experience different levels of response to the medication. Therefore, it is important to take AMPYRA as prescribed by your doctor."
Answered by AI