Aminophylline

Bronchial Spasm, Asthma, Asthma + 4 more
Treatment
20 Active Studies for Aminophylline

What is Aminophylline

AminophyllineThe Generic name of this drug
Treatment SummaryAminophylline is a combination of two drugs, theophylline and ethylenediamine, that work together to treat lung diseases such as asthma, chronic bronchitis, and COPD. Theophylline, the active ingredient in aminophylline, works by blocking certain enzymes and receptors in the body and activating histone deacetylase. Most forms of aminophylline are no longer available, and the remaining medications are in short supply.
Aminophyllineis the brand name
image of different drug pills on a surface
Aminophylline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aminophylline
Aminophylline
1975
22

Effectiveness

How Aminophylline Affects PatientsAminophylline is a drug derived from theophylline. It activates the brain, muscles, and heart and relaxes the airways in the lungs. It can also increase urination and the production of stomach acid.
How Aminophylline works in the bodyAminophylline helps open up the airways in the lungs by relaxing the surrounding muscles. It does this by blocking an enzyme that breaks down a chemical called cyclic AMP that helps control muscle movement. Aminophylline also blocks a receptor that responds to a chemical called adenosine, which can cause the airways to close. Additionally, it helps reduce inflammation by stopping certain genes from activating.

When to interrupt dosage

The prescribed measure of Aminophylline is contingent upon the diagnosed situation, comprising of Chronic Bronchitis, Lung Disorder and Bronchospasm. The quantity of dosage differs, depending on the technique of delivery (e.g. Intravenous or Suppository) featured in the table below.
Condition
Dosage
Administration
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal
Bronchitis
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal
Bronchial Spasm
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal
Lung Diseases
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal
Bronchitis, Chronic
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Oral, Injection - Intravenous, Injection, Rectal, Suppository, Suppository - Rectal

Warnings

There are 20 known major drug interactions with Aminophylline.
Common Aminophylline Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Aminophylline.
Amobarbital
Major
The therapeutic efficacy of Amobarbital can be decreased when used in combination with Aminophylline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Aminophylline.
Barbexaclone
Major
The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Aminophylline.
Barbital
Major
The therapeutic efficacy of Barbital can be decreased when used in combination with Aminophylline.
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Aminophylline Novel Uses: Which Conditions Have a Clinical Trial Featuring Aminophylline?

158 active clinical trials are assessing the potential of Aminophylline in managing Bronchitis, Chronic Bronchitis and Asthma.
Condition
Clinical Trials
Trial Phases
Asthma
92 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3
Bronchitis, Chronic
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Bronchial Spasm
0 Actively Recruiting
Asthma
1 Actively Recruiting
Phase 4
Asthma
4 Actively Recruiting
Not Applicable, Phase 4
Lung Diseases
5 Actively Recruiting
Phase 1, Phase 2, Not Applicable

Aminophylline Reviews: What are patients saying about Aminophylline?

1.7Patient Review
12/7/2015
Aminophylline for Bronchospasm
I had to get a lot of injections of this drug and it improved my breathing, but now I can't use my veins anymore. In my opinion, this should only be used as a last resort.
1.7Patient Review
4/11/2011
Aminophylline for Bronchitis
This didn't work for me at all.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aminophylline

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is aminophylline used for?

"Aminophylline is used in conjunction with other medications to mitigate the acute symptoms of asthma, bronchitis, emphysema, and other pulmonary diseases in a hospital setting. Aminophylline is classified as a bronchodilator."

Answered by AI

What is difference between aminophylline and theophylline?

"It stimulates the central nervous system, skeletal muscles, and cardiac muscle. It also relaxes certain smooth muscles in the bronchi, helps the body produce urine, and increases gastric secretion."

Answered by AI

What is another name for aminophylline?

"Theophylline goes by many different names, including Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl."

Answered by AI

Why Aminophylline is given slowly?

"The direct stimulating effect of aminophylline can cause dangerous side-effects on the central nervous system and cardiovascular system. Intravenous administration of aminophylline should not exceed a rate of 25 mg/min."

Answered by AI

Clinical Trials for Aminophylline

Have you considered Aminophylline clinical trials? We made a collection of clinical trials featuring Aminophylline, we think they might fit your search criteria.Go to Trials
Image of Allergy Immunology Associates in Mayfield Heights, United States.

Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
Image of DARTNet Institute in Aurora, United States.

Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
Image of Medical Place Pharmacy in Ajax, Canada.

Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
Have you considered Aminophylline clinical trials? We made a collection of clinical trials featuring Aminophylline, we think they might fit your search criteria.Go to Trials
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PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Aminophylline clinical trials? We made a collection of clinical trials featuring Aminophylline, we think they might fit your search criteria.Go to Trials