Aminophylline

Bronchospasm, Asthma, Bronchial Asthma + 4 more
Treatment
20 Active Studies for Aminophylline

What is Aminophylline

AminophyllineThe Generic name of this drug
Treatment SummaryAminophylline is a combination of two drugs, theophylline and ethylenediamine, that work together to treat lung diseases such as asthma, chronic bronchitis, and COPD. Theophylline, the active ingredient in aminophylline, works by blocking certain enzymes and receptors in the body and activating histone deacetylase. Most forms of aminophylline are no longer available, and the remaining medications are in short supply.
Aminophyllineis the brand name
image of different drug pills on a surface
Aminophylline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aminophylline
Aminophylline
1975
22

Effectiveness

How Aminophylline Affects PatientsAminophylline is a drug derived from theophylline. It activates the brain, muscles, and heart and relaxes the airways in the lungs. It can also increase urination and the production of stomach acid.
How Aminophylline works in the bodyAminophylline helps open up the airways in the lungs by relaxing the surrounding muscles. It does this by blocking an enzyme that breaks down a chemical called cyclic AMP that helps control muscle movement. Aminophylline also blocks a receptor that responds to a chemical called adenosine, which can cause the airways to close. Additionally, it helps reduce inflammation by stopping certain genes from activating.

When to interrupt dosage

The prescribed measure of Aminophylline is contingent upon the diagnosed situation, comprising of Chronic Bronchitis, Lung Disorder and Bronchospasm. The quantity of dosage differs, depending on the technique of delivery (e.g. Intravenous or Suppository) featured in the table below.
Condition
Dosage
Administration
Bronchospasm
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Lung Disorder
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Bronchial Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Chronic Bronchitis
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Bronchitis
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal

Warnings

There are 20 known major drug interactions with Aminophylline.
Common Aminophylline Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Aminophylline.
Amobarbital
Major
The therapeutic efficacy of Amobarbital can be decreased when used in combination with Aminophylline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Aminophylline.
Barbexaclone
Major
The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Aminophylline.
Barbital
Major
The therapeutic efficacy of Barbital can be decreased when used in combination with Aminophylline.
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Aminophylline Novel Uses: Which Conditions Have a Clinical Trial Featuring Aminophylline?

158 active clinical trials are assessing the potential of Aminophylline in managing Bronchitis, Chronic Bronchitis and Asthma.
Condition
Clinical Trials
Trial Phases
Bronchitis
0 Actively Recruiting
Asthma
1 Actively Recruiting
Not Applicable
Bronchial Asthma
1 Actively Recruiting
Phase 3
Bronchospasm
0 Actively Recruiting
Asthma
155 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Chronic Bronchitis
5 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Lung Disorder
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Aminophylline Reviews: What are patients saying about Aminophylline?

1.7Patient Review
12/7/2015
Aminophylline for Bronchospasm
I had to get a lot of injections of this drug and it improved my breathing, but now I can't use my veins anymore. In my opinion, this should only be used as a last resort.
1.7Patient Review
4/11/2011
Aminophylline for Bronchitis
This didn't work for me at all.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aminophylline

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is aminophylline used for?

"Aminophylline is used in conjunction with other medications to mitigate the acute symptoms of asthma, bronchitis, emphysema, and other pulmonary diseases in a hospital setting. Aminophylline is classified as a bronchodilator."

Answered by AI

What is difference between aminophylline and theophylline?

"It stimulates the central nervous system, skeletal muscles, and cardiac muscle. It also relaxes certain smooth muscles in the bronchi, helps the body produce urine, and increases gastric secretion."

Answered by AI

What is another name for aminophylline?

"Theophylline goes by many different names, including Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl."

Answered by AI

Why Aminophylline is given slowly?

"The direct stimulating effect of aminophylline can cause dangerous side-effects on the central nervous system and cardiovascular system. Intravenous administration of aminophylline should not exceed a rate of 25 mg/min."

Answered by AI

Clinical Trials for Aminophylline

Have you considered Aminophylline clinical trials? We made a collection of clinical trials featuring Aminophylline, we think they might fit your search criteria.
Have you considered Aminophylline clinical trials? We made a collection of clinical trials featuring Aminophylline, we think they might fit your search criteria.
Have you considered Aminophylline clinical trials? We made a collection of clinical trials featuring Aminophylline, we think they might fit your search criteria.