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What is Amantadine Hydrochloride
AmantadineThe Generic name of this drug
Treatment SummaryAmantadine is an antiviral drug used to prevent and treat influenza A, an infectious disease caused by a virus. It can also be prescribed to reduce the symptoms of Parkinson's Disease and postherpetic neuralgia. The medication works by increasing the amount of dopamine in the body, which helps control movement and coordination.
Symmetrelis the brand name
Amantadine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Symmetrel
Amantadine
1976
103
Approved as Treatment by the FDA
Amantadine, also called Symmetrel, is approved by the FDA for 8 uses like Dyskinesia and Parkinsonism .Dyskinesia
Used in combination with other therapies
Parkinsonism
Helps manage Parkinsonism
Parkinson's Disease
Helps manage Parkinson's Disease (PD)
prophylaxis of Influenza A virus infection
influenza A virus
Pharmacotherapy
Used in combination with other therapies
Parkinson Disease
Used in combination with other therapies
Extrapyramidal Disorders
Effectiveness
How Amantadine Hydrochloride Affects PatientsAmantadine is a drug that is used to treat both viral infections and Parkinson's disease. It works differently than other Parkinson's drugs, such as L-DOPA, and is not fully understood. Studies have shown that Amantadine increases dopamine release in the brain and does not have any anticholinergic effects.
How Amantadine Hydrochloride works in the bodyThe exact way this drug combats Parkinson's disease is a mystery, but it appears to increase dopamine levels in the brain and stimulate noradrenaline response. It also seems to block NMDA receptors. The antiviral effects are unrelated and work by preventing a viral protein, M2, from uncoating inside a cell.
When to interrupt dosage
The suggested amount of Amantadine Hydrochloride is contingent upon the diagnosed disorder, including influenza A virus, Restless Legs Syndrome (RLS) and Parkinson's Disease. The dosage level is contingent on the delivery approach (e.g. Capsule - Oral or Oral) specified in the table beneath.Condition
Dosage
Administration
Parkinsonism
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Extrapyramidal Disorders
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
prophylaxis of Influenza A virus infection
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
influenza A virus
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Parkinson Disease
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Dyskinesia
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Parkinson's Disease
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Pharmacotherapy
50.0 mg/mL, , 100.0 mg, 68.5 mg, 137.0 mg, 129.0 mg, 193.0 mg, 258.0 mg, 10.0 mg/mL, 1.0 mg/mg, 8.0 mg/mg, 322.0 mg, 161.0 mg
, Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Syrup, Syrup - Oral, Topical, Kit, Kit - Topical, Tablet - Oral, Tablet, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Amantadine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amantadine may interact with Pulse Frequency
Common Amantadine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Adenovirus type 7 vaccine live
Major
The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Amantadine.
Anthrax vaccine
Major
The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Amantadine.
BCG vaccine
Major
The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Amantadine.
Bacillus calmette-guerin substrain connaught live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Amantadine.
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Amantadine.
Amantadine Hydrochloride Toxicity & Overdose RiskTaking too much amantadine can be fatal, and the lowest reported lethal dose is 2 grams. Overdosing on amantadine can lead to heart issues, breathing problems, kidney damage, and damage to the nervous system. Symptoms of cardiac dysfunction can include abnormal heart rhythm, rapid heart rate, and high blood pressure. Other effects may include confusion, disorientation, hallucinations, aggression, hyperactivity, seizures, and coma. Hyperthermia (high body temperature) may also be present.
Amantadine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Amantadine Hydrochloride?
340 active clinical trials are in progress to ascertain the potential of Amantadine Hydrochloride to alleviate Parkinsonism post encephalitic, Parkinsonism and Chorea.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
prophylaxis of Influenza A virus infection
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
Parkinson Disease
0 Actively Recruiting
influenza A virus
4 Actively Recruiting
Not Applicable
Parkinsonism
3 Actively Recruiting
Phase 4
Dyskinesia
1 Actively Recruiting
Phase 3
Extrapyramidal Disorders
0 Actively Recruiting
Amantadine Hydrochloride Reviews: What are patients saying about Amantadine Hydrochloride?
5Patient Review
7/2/2014 I've been taking this for two weeks to help with my MS. It does give me more energy, but I'm not sure if the side effects are worth it. They include: shaking, weakness, and hand tremors. Going to talk to my doctor soon.
5Patient Review
2/27/2016 Amantadine has helped me feel better overall, with fewer "off" periods. The only downside is that it seems to cause insomnia, but so far that's the only negative effect I've noticed.
4.7Patient Review
12/27/2019 This medication has been great in addressing my husband's shakes and spasms. The only downside is that he's having more bad dreams than usual, which is quite out of character for him.
4.7Patient Review
5/8/2016 This drug has been working great for me for many years, but as my illness has progressed, it's become less and less effective.
4.7Patient Review
6/26/2015 I only take this medication when I am experiencing fatigue, even though I have had enough sleep.
4.3Patient Review
4/14/2016 I've found that this treatment helps me to feel more alert and focused during the day. However, if I go more than a few days without taking it, the symptoms come back. Thankfully, there haven't been any negative side effects for me.
4.3Patient Review
1/28/20144Patient Review
1/3/2016 While this treatment has helped me in some ways, I find that it makes me depressed every evening after taking the evening dose.
4Patient Review
11/3/2015 My son experienced a traumatic brain injury due to a motorcycle accident. We started him on amantadine one month after the accident and saw almost immediate improvement in his cognition. He continued taking amantadine for the next six months and saw continued improvement with physical, occupational, and speech therapy.
3.7Patient Review
6/5/2014 I was in a car accident and suffered from a concussion. I took this drug in the hopes that it would help my brain transmitters work more effectively, but didn't really notice much of a difference other than increased fogginess.
3.7Patient Review
10/6/2015 I've been struggling to sleep, so my doctor recommended I take this medication. So far, taking one around 10am has helped me get through the day without feeling too groggy.
3.3Patient Review
9/19/2014 I've been on this medication for seven months now and have begun to notice significant swelling in my lower extremities. This has gotten to the point where I can't even get my shoes on. I'm planning on asking my doctor to take me off of it.
3.3Patient Review
7/16/2016 I initially felt nauseous when starting this medication,
3Patient Review
5/13/2015 So far, this has been a lifesaver for me. I've had this problem for close to a year and haven't been able to get a diagnosis. I'm on my third neurologist and will probably change drugs this year.
2.3Patient Review
1/30/2015 My neurologist originally prescribed me provigil to help with my fatigue, but since my insurance company wouldn't approve it, he switched me to amantadine. While it did help a little bit with the fatigue, it triggered my schizoaffective psychosis and hallucinations. He then put me on vyvanse instead, which was the best decision ever.
2.3Patient Review
8/19/2014 I have been living with MS for 37 years and, unfortunately, this medication did not help me manage my symptoms at all.
1.7Patient Review
9/24/2014 I was given this medication to help me with my severe fatigue, but it unfortunately did not work at all. In addition, I developed a nasty rash on my inner thigh that took two weeks to resolve itself.
Patient Q&A Section about amantadine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is amantadine hydrochloride used for?
"Amantadine is a drug used to treat symptoms of [Parkinson's disease](https://www.withpower.com/clinical-trials/parkinson's-disease), including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other drugs for Parkinson's disease."
Answered by AI
What are the side effects of amantadine and what is it used for?
"Amantadine is a drug used to treat Parkinson's disease. While minor side effects are common, more severe and dangerous side effects are less likely. These severe side effects can include NMS, suicidal thoughts or behaviors, psychosis, and heart problems."
Answered by AI
Does amantadine treat Covid 19?
"Compared to placebo, using high doses of amantadine in hospitalized patients in the early phase of moderate or severe COVID-19 will shorten the duration of the disease, reduce the risk of death, and reduce the need for treatment with invasive mechanical ventilation in Intensive Care Units (ICU)."
Answered by AI
When should amantadine be given?
"The recommended dosage for adults is 137 mg once a day at bedtime. After one week, your doctor may increase the dosage to 274 mg (two 137 mg capsules) once a day at bedtime. The dosage for children must be determined by your doctor."
Answered by AI