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What is Afeditab Cr
NifedipineThe Generic name of this drug
Treatment SummaryNifedipine is a medication used to relax and widen the blood vessels, allowing the heart to pump more efficiently. It belongs to a class of drugs called calcium channel blockers and was first developed by Bayer in 1972. Nifedipine was approved by the FDA in 1981 and is similar to other drugs like nicardipine and amlodipine, which are newer generations of dihydropyridines with slower onset and longer duration times.
Procardiais the brand name
Afeditab Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Procardia
Nifedipine
1981
355
Approved as Treatment by the FDA
Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Vasospastic Angina and Chronic Stable Angina Pectoris .Vasospastic Angina
Helps manage Vasospastic Angina
Chronic Stable Angina Pectoris
Helps manage Chronic Stable Angina Pectoris
Failed conventional therapy
Helps manage Failed conventional therapy
Effectiveness
How Afeditab Cr Affects PatientsNifedipine is a drug that helps lower blood pressure and increase oxygen levels to the heart. It usually needs to be taken three times a day in doses of 10-120mg. Patients should be warned of the potential side effects, such as dangerously low blood pressure, chest pain, and heart attack.
How Afeditab Cr works in the bodyNifedipine decreases the amount of calcium that can enter cells in your veins and arteries, making them wider and reducing blood pressure. It also increases the amount of oxygen getting to the heart, relieving the chest pain of angina.
When to interrupt dosage
The prescribed dosage of Afeditab Cr is contingent upon the diagnosed condition, such as Achalasia, Ureteral Calculus and Hypertensive disease. The amount of dosage fluctuates, according to the form of administration (e.g. Tablet, film coated, extended release or Capsule) presented in the table below.Condition
Dosage
Administration
Anal sphincter hypertonia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Other and unspecified effects of high altitude
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Chronic Stable Angina Pectoris
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Proctalgia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Achalasia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Hypertension
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Vasospastic Angina
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Raynaud's Phenomenon
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Edemas
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Premature Labour
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive Emergency
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Ureteral Calculus
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Fissure;Anal
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Failed conventional therapy
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Warnings
Afeditab Cr has one contraindication, so it should not be taken concomitantly with any of the conditions indicated in the following table.Afeditab Cr ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Nifedipine may interact with Pulse Frequency
Common Afeditab Cr Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nifedipine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nifedipine.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.
Afeditab Cr Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 1022mg/kg and in mice is 202mg/kg. Those who overdose on the drug may experience low blood pressure, abnormal heart rhythms, and a faster than normal heart rate. Treatment includes monitoring vital signs, raising the patient's extremities, and administering fluids, vasopressors, and calcium infusions.
Afeditab Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Afeditab Cr?
Currently, 101 active clinical trials are investigating the possible benefits of Afeditab Cr in Achalasia, Hypertensive Emergency and Anal Fissure management.Condition
Clinical Trials
Trial Phases
Fissure;Anal
0 Actively Recruiting
Anal sphincter hypertonia
0 Actively Recruiting
Vasospastic Angina
0 Actively Recruiting
Failed conventional therapy
0 Actively Recruiting
Raynaud's Phenomenon
1 Actively Recruiting
Phase 4
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Pulmonary Hypertension
25 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Proctalgia
0 Actively Recruiting
Pulmonary Edemas
0 Actively Recruiting
Ureteral Calculus
0 Actively Recruiting
Achalasia
7 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Other and unspecified effects of high altitude
0 Actively Recruiting
Premature Labour
4 Actively Recruiting
Not Applicable, Phase 2
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Afeditab Cr Reviews: What are patients saying about Afeditab Cr?
5Patient Review
1/30/2011 At first, this medication really helped me. However, now I find that it gives me headaches. That said, my blood pressure has lowered since taking this pill so overall I'm happy with it.
5Patient Review
10/9/2010 This treatment is excellent for lowering blood pressure, but a side effect I've noticed is that my gums keep swelling.
4.3Patient Review
8/9/2009 I was on this medication for two weeks and saw a significant decrease in my blood pressure. I unfortunately had to stop taking it because the headaches it caused me were unbearable.
2Patient Review
2/2/2009Patient Q&A Section about afeditab cr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does CR tablet mean?
"Abbreviations that are commonly used by pharmaceutical companies to denote short- and long-acting medications include CR for “controlled release”, SR for “sustained release”, ER for “extended release”, and IR for “immediate release”."
Answered by AI
Is Afeditab the same as nifedipine?
"The tablets come in two different strengths, 30 mg or 60 mg. They are taken orally once per day."
Answered by AI
How does nifedipine work?
"Nifedipine is a calcium channel blocker that works by affecting the movement of calcium into the cells of the heart and blood vessels. By reducing the workload of the heart, nifedipine increases the supply of blood and oxygen to the heart while relaxing blood vessels."
Answered by AI
Should I take high blood pressure medication?
"If your blood pressure is high or you have other health problems that put you at risk for heart attack or stroke, your doctor mayrecommend medication to help lower your blood pressure."
Answered by AI