Radical external beam radiotherapy for Colorectal Carcinoma (CRC)

"Environmental and genetic factors influence CRC risks. These effects are not well established and it seems likely that multiple low-probability causal factors may operate and that the genetic risk is modified by the environment." - Anonymous Online Contributor

"Common treatments for [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) include surgery, chemotherapy, radiotherapy, immunotherapy and targeted therapies. Surgery is the most common method of treatment. For advanced cancers chemotherapy and radiotherapy are equally effective, with no significant differences in survival." - Anonymous Online Contributor

"There are many symptoms of colorectal cancer, but when you have only one symptom that it can be really hard to diagnose because there are so many different types of colorectal cancer. So it is important to be very careful. Symptoms include blood in your stool, feeling tired, changes in bowel habits, weight loss, change in color of the skin, fever, sore mouth, or unexplained pain in the belly. In the case of constipation/obstructive colon cancer, you need to get medical care immediately. If any of these symptoms persist for more than 2 months, contact your doctor." - Anonymous Online Contributor

"Stage 1 and 2 [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) can be cured in most cases. Stage 3 and 4 cancer are more difficult to cure, depending on the stage of disease. In cases of advanced colorectal cancer, however, a small number of patients achieve a complete remission." - Anonymous Online Contributor

"Colorectal cancer affects about 1 in 12 persons in the United States, and 1 out of 10 persons is diagnosed with colon cancer. While colon and rectal cancers account for 60% of new cases in 2000, approximately 75% of persons diagnosed with colorectal cancer had a local disease at the time of diagnosis." - Anonymous Online Contributor

"If early diagnosis is achieved, this disease has a high rate of cure. The incidence of colorectal cancer in North Korea has been increasing steadily since the 1970’s. In the past, the incidence of colorectal cancer was about 50 per 1000,000 in North Korea(1). Now, it is above 150 per 1000,000(2)." - Anonymous Online Contributor

"The survival rate for colorectal cancer has remained relatively unchanged between 1993 and 2005. Despite the improved outcomes over the years, there are still disparities, which need to be addressed, especially with regard to race, socioeconomic status, and age. For patients diagnosed with stage II and III disease, the 5-year survival rate for black patients was 56% compared with 82% for white patients." - Anonymous Online Contributor

"Screening by a colonoscopy should be recommended at an early age and should be done once every 10 years. Screening patients who use statins is probably harmful. There are very high quality trials about polyp detection and adenoma screening (colonoscopy) with a very close follow-up. In a recent study, findings of each trial are reviewed." - Anonymous Online Contributor

"The chances are very high if one has one or more of the three risk factors, namely smoking, familial adenomatous polyposis and advanced age. There has been much discussion about how colorectal cancer is prevented, particularly in developed countries. However, in a developing country the chance of catching and dying of colorectal cancer are very high without any colorectal cancer screening. However, it is not necessarily that all colorectal cancers in the developed world are preventable by screening. For instance, in our study, most of the patients were of low social class, and they have low socioeconomic levels in the developed world." - Anonymous Online Contributor

"While there is a need to use more definitive and/or intensive modalities of treatment for metastatic colorectal cancer, EBRT appears to be safe in selected patients. More studies are needed to identify the optimal number of fractions for an effective treatment and quantify EBRT associated morbidity and mortality." - Anonymous Online Contributor

"In the interest of all stakeholders, there is little room for error, and the role of the CRCT/HNC in this regard is to provide the best opportunity for patients to gain the greatest benefit from their research funding." - Anonymous Online Contributor

"As the likelihood for colorectal cancer as well as the incidence and distribution of age at diagnosis in the families were similar to the observed trend in the general population, a genetic component is also suggested for the development of colorectal cancer. Although no clear relationship between familiality and age-adjusted survival was seen after adjustment for sex and site, the present study suggests that colorectal cancer in families may be sporadic." - Anonymous Online Contributor