Radical external beam radiotherapy for Colorectal Carcinoma (CRC)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
McGill University Health Centre- Cedars Cancer Centre, Montreal, Canada
Colorectal Carcinoma (CRC)+1 More
Radical external beam radiotherapy - Radiation
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This study is evaluating whether a combination of radiotherapy and chemotherapy can cure rectal cancer.

See full description

Eligible Conditions

  • Colorectal Carcinoma (CRC)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Colorectal Carcinoma (CRC)

Study Objectives

This trial is evaluating whether Radical external beam radiotherapy will improve 1 primary outcome in patients with Colorectal Carcinoma (CRC). Measurement will happen over the course of One year.

One year
Feasibility of a "wait and see" approach

Trial Safety

Safety Progress

1 of 3

Other trials for Colorectal Carcinoma (CRC)

Trial Design

1 Treatment Group

Radical External Beam RT for Colorectal Ca
1 of 1
Experimental Treatment

This trial requires 48 total participants across 1 different treatment group

This trial involves a single treatment. Radical External Beam Radiotherapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Radical External Beam RT for Colorectal Ca
Radiation
A single arm consisting of: Radical external beam RT dose of 54 Gy in 30fx with radiosensitizing chemotherapy as per institutional standard

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: one year
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly one year for reporting.

Who is running the study

Principal Investigator
N. K.
Neil Kopek, Principal Investigator
McGill University Health Centre/Research Institute of the McGill University Health Centre

Closest Location

McGill University Health Centre- Cedars Cancer Centre - Montreal, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Colorectal Carcinoma (CRC) or the other condition listed above. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
A mesorectal lymph node is a lymph node located in the mesorectum, the middle part of the rectum. show original
Serum transaminase <3 x ULN;
There is no evidence of disease that has spread to other parts of the body. show original
The mesorectum is involved or breached, which includes involvement of the adjacent organs. show original
The involvement of the muscularis propria is seen at T2. show original
extra-mural vascular invasion
The tumor is located within the part of the intestine called the mesorectum. show original
if they are without evidence of distant metastasis, have a good performance status, and have a tumor that can be locally resected show original
The patient has a good performance status. show original
The patient has a high absolute neutrophil count and high platelets. show original

Patient Q&A Section

What causes colorectal cancer?

"Environmental and genetic factors influence CRC risks. These effects are not well established and it seems likely that multiple low-probability causal factors may operate and that the genetic risk is modified by the environment." - Anonymous Online Contributor

Unverified Answer

What are common treatments for colorectal cancer?

"Common treatments for [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) include surgery, chemotherapy, radiotherapy, immunotherapy and targeted therapies. Surgery is the most common method of treatment. For advanced cancers chemotherapy and radiotherapy are equally effective, with no significant differences in survival." - Anonymous Online Contributor

Unverified Answer

What are the signs of colorectal cancer?

"There are many symptoms of colorectal cancer, but when you have only one symptom that it can be really hard to diagnose because there are so many different types of colorectal cancer. So it is important to be very careful. Symptoms include blood in your stool, feeling tired, changes in bowel habits, weight loss, change in color of the skin, fever, sore mouth, or unexplained pain in the belly. In the case of constipation/obstructive colon cancer, you need to get medical care immediately. If any of these symptoms persist for more than 2 months, contact your doctor." - Anonymous Online Contributor

Unverified Answer

Can colorectal cancer be cured?

"Stage 1 and 2 [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) can be cured in most cases. Stage 3 and 4 cancer are more difficult to cure, depending on the stage of disease. In cases of advanced colorectal cancer, however, a small number of patients achieve a complete remission." - Anonymous Online Contributor

Unverified Answer

How many people get colorectal cancer a year in the United States?

"Colorectal cancer affects about 1 in 12 persons in the United States, and 1 out of 10 persons is diagnosed with colon cancer. While colon and rectal cancers account for 60% of new cases in 2000, approximately 75% of persons diagnosed with colorectal cancer had a local disease at the time of diagnosis." - Anonymous Online Contributor

Unverified Answer

What is colorectal cancer?

"If early diagnosis is achieved, this disease has a high rate of cure. The incidence of colorectal cancer in North Korea has been increasing steadily since the 1970’s. In the past, the incidence of colorectal cancer was about 50 per 1000,000 in North Korea(1). Now, it is above 150 per 1000,000(2)." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for colorectal cancer?

"The survival rate for colorectal cancer has remained relatively unchanged between 1993 and 2005. Despite the improved outcomes over the years, there are still disparities, which need to be addressed, especially with regard to race, socioeconomic status, and age. For patients diagnosed with stage II and III disease, the 5-year survival rate for black patients was 56% compared with 82% for white patients." - Anonymous Online Contributor

Unverified Answer

What is the latest research for colorectal cancer?

"Screening by a colonoscopy should be recommended at an early age and should be done once every 10 years. Screening patients who use statins is probably harmful. There are very high quality trials about polyp detection and adenoma screening (colonoscopy) with a very close follow-up. In a recent study, findings of each trial are reviewed." - Anonymous Online Contributor

Unverified Answer

What are the chances of developing colorectal cancer?

"The chances are very high if one has one or more of the three risk factors, namely smoking, familial adenomatous polyposis and advanced age. There has been much discussion about how colorectal cancer is prevented, particularly in developed countries. However, in a developing country the chance of catching and dying of colorectal cancer are very high without any colorectal cancer screening. However, it is not necessarily that all colorectal cancers in the developed world are preventable by screening. For instance, in our study, most of the patients were of low social class, and they have low socioeconomic levels in the developed world." - Anonymous Online Contributor

Unverified Answer

Is radical external beam radiotherapy safe for people?

"While there is a need to use more definitive and/or intensive modalities of treatment for metastatic colorectal cancer, EBRT appears to be safe in selected patients. More studies are needed to identify the optimal number of fractions for an effective treatment and quantify EBRT associated morbidity and mortality." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for colorectal cancer?

"In the interest of all stakeholders, there is little room for error, and the role of the CRCT/HNC in this regard is to provide the best opportunity for patients to gain the greatest benefit from their research funding." - Anonymous Online Contributor

Unverified Answer

Does colorectal cancer run in families?

"As the likelihood for colorectal cancer as well as the incidence and distribution of age at diagnosis in the families were similar to the observed trend in the general population, a genetic component is also suggested for the development of colorectal cancer. Although no clear relationship between familiality and age-adjusted survival was seen after adjustment for sex and site, the present study suggests that colorectal cancer in families may be sporadic." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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