Advair Hfa

Asthma, Chronic Obstructive Pulmonary Disease, Bronchospasm, Exercise-Induced + 1 more

Treatment

7 FDA approvals

20 Active Studies for Advair Hfa

Treatment for

Asthma

What is Advair Hfa

SalmeterolThe Generic name of this drug

Treatment SummarySalmeterol is a long-acting medication used to treat asthma and COPD. It works by activating the beta-2 adrenergic receptors and has a longer duration of action than other similar medications. It was first introduced in 1988 and was approved by the FDA in 1994. Salmeterol’s structure is similar to another medication called salbutamol, but it has an aralkyloxy-alkyl substitution on its amine.

Serevent Diskusis the brand name

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Advair Hfa Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Serevent Diskus

Salmeterol

1997

Approved as Treatment by the FDA

Salmeterol, otherwise called Serevent Diskus, is approved by the FDA for 7 uses including Asthma, Exercise-Induced and Exercise-Induced Bronchospasm .

Asthma, Exercise-Induced

Exercise-Induced Bronchospasm

Asthma

Used to treat Asthma in combination with Fluticasone propionate

prophylaxis of Exercise-induced bronchospasm

Asthma

Used to treat Asthma in combination with Fluticasone propionate

Chronic Obstructive Pulmonary Disease

Helps manage Chronic Obstructive Pulmonary Disease (COPD)

Bronchospasm, Exercise-Induced

Effectiveness

How Advair Hfa Affects PatientsSalmeterol is a long-lasting medicine that works to relax the muscles around the airways. It is more effective than other similar drugs, like salbutamol. Patients should be aware of the risks of taking salmeterol, including low levels of potassium or sugar in the blood, and not taking this drug with another long-acting beta agonist.

How Advair Hfa works in the bodySalmeterol works by binding to two sites on the beta-2 adrenoceptor, a receptor in the lungs. It is hypothesized that the saligenin part binds to the active site of the receptor, while the hydrophilic tail binds to leucine residues in the exo-site, which allows it to persist in the active site for a longer period of time. Another hypothesis is that the drug diffuses into the cells of the lungs and provides a depot of drug to the cells over a longer period of time. This helps relax the muscles in the lungs and increases airflow.

When to interrupt dosage

The suggested portion of Advair Hfa is contingent upon the determined condition, such as Exercise-Induced Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD) and Bronchospasm, Exercise-Induced. The amount of dosage changes in view of the approach of application detailed in the table below.

Condition

Dosage

Administration

Bronchospasm, Exercise-Induced

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)

Asthma, Exercise-Induced

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Asthma

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Chronic Obstructive Pulmonary Disease

, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg

Warnings

Advair Hfa has five contraindications, thus it should not be taken if one is suffering from any of the conditions in the below table.Advair Hfa Contraindications

Condition

Risk Level

Notes

Status Asthmaticus

Do Not Combine

Chronic Obstructive Airway Disease

Do Not Combine

Not being treated with an inhaled corticosteroid

Do Not Combine

Asthma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Salmeterol may interact with Pulse Frequency

There are 20 known major drug interactions with Advair Hfa.

Common Advair Hfa Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Salmeterol.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Salmeterol.

Almotriptan

Major

The metabolism of Almotriptan can be decreased when combined with Salmeterol.

Aminophenazone

Major

The metabolism of Aminophenazone can be decreased when combined with Salmeterol.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Salmeterol.

Advair Hfa Toxicity & Overdose RiskOverdosing on salmeterol can cause acid buildup in the body, increased lactic acid levels, anxiety, rapid heartbeat, changes in heart rhythm, low potassium levels, and low phosphorus levels. Other symptoms may include seizures, chest pain, high or low blood pressure, irregular heartbeat, headache, muscle cramps, dry mouth, nausea, dizziness, fatigue, and high blood sugar. Treatment may involve intravenous fluids, potassium supplements, a type of medication to protect the heart, and monitoring the patient's heart. There is not enough data available to determine the exact toxicity level for salmeterol.

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Advair Hfa Novel Uses: Which Conditions Have a Clinical Trial Featuring Advair Hfa?

244 active trials are currently being conducted to assess the efficacy of Advair Hfa in alleviating Exercise-Induced Bronchospasm, Bronchospasm, Exercise-Induced Bronchospasm and Chronic Obstructive Pulmonary Disease (COPD).

Condition

Clinical Trials

Trial Phases

Asthma

89 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Chronic Obstructive Pulmonary Disease

85 Actively Recruiting

Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4

Bronchospasm, Exercise-Induced

0 Actively Recruiting

Asthma, Exercise-Induced

1 Actively Recruiting

Not Applicable

Advair Hfa Reviews: What are patients saying about Advair Hfa?

5Patient Review

3/28/2010

Advair Hfa for Asthma

While this medication did improve my breathing, it unfortunately also caused a drastic and dangerous increase in blood pressure. This made asthma a double-edged sword-- do I die from not being able to breathe or from a stroke? Either way, the high blood pressure prevented me from living a normal life. Other side effects included weight gain, irritability, sudden crying episodes, and overall feelings of sickness.

5Patient Review

10/12/2009

Advair Hfa for Asthma

5Patient Review

8/11/2010

Advair Hfa for Chronic Obstructive Lung Disease

While this medication does work well for me, I have experienced some terrible leg cramps as a result.

5Patient Review

3/1/2013

Advair Hfa for Asthma

This medication has helped me breathe better.

4.3Patient Review

11/5/2010

Advair Hfa for Allergic Asthma

This treatment is really effective. I've tried a lot of different treatments, and this one is by far the best.

View All Reviews

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Patient Q&A Section about advair hfa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Advair HFA the same as albuterol?

"Fluticasone/salmeterol (Advair) is used to treat asthma and make it easier to breathe. Albuterol (ProAir HFA) is used to quickly stop asthma attacks and help you breathe easier, but it is not for long-term treatment or prevention of asthma since the effects don't last long."

Answered by AI

What is the difference between Advair and Advair HFA?

"ADVAIR DISKUS is a prescription medicine that is used to treat asthma in patients who are four years of age or older. ADVAIR HFA is a prescription medicine that is used to treat asthma in patients who are twelve years of age or older."

Answered by AI

Is Advair HFA a steroid inhaler?

"Yes, Advair is a type of steroid. It is a mixture of a steroid (fluticasone) and a long-acting bronchodilator (salmeterol). Advair is used to treat asthma and COPD."

Answered by AI

How long does it take Advair HFA to work?

"You may not see the full effects of this drug for a week or longer. Tell your doctor if your symptoms don't improve or get worse."

Answered by AI

Clinical Trials for Advair Hfa

Have you considered Advair Hfa clinical trials? We made a collection of clinical trials featuring Advair Hfa, we think they might fit your search criteria.

Have you considered Advair Hfa clinical trials? We made a collection of clinical trials featuring Advair Hfa, we think they might fit your search criteria.