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What is Advair Hfa
SalmeterolThe Generic name of this drug
Treatment SummarySalmeterol is a long-acting medication used to treat asthma and COPD. It works by activating the beta-2 adrenergic receptors and has a longer duration of action than other similar medications. It was first introduced in 1988 and was approved by the FDA in 1994. Salmeterol’s structure is similar to another medication called salbutamol, but it has an aralkyloxy-alkyl substitution on its amine.
Serevent Diskusis the brand name
Advair Hfa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Serevent Diskus
Salmeterol
1997
77
Approved as Treatment by the FDA
Salmeterol, otherwise called Serevent Diskus, is approved by the FDA for 4 uses including Chronic Obstructive Pulmonary Disease and Asthma .Chronic Obstructive Pulmonary Disease
Helps manage Chronic Obstructive Pulmonary Disease (COPD)
Asthma
Used to treat Asthma in combination with Fluticasone propionate
Exercise-Induced Bronchospasm
Bronchospasm, Exercise-Induced
Effectiveness
How Advair Hfa Affects PatientsSalmeterol is a long-lasting medicine that works to relax the muscles around the airways. It is more effective than other similar drugs, like salbutamol. Patients should be aware of the risks of taking salmeterol, including low levels of potassium or sugar in the blood, and not taking this drug with another long-acting beta agonist.
How Advair Hfa works in the bodySalmeterol works by binding to two sites on the beta-2 adrenoceptor, a receptor in the lungs. It is hypothesized that the saligenin part binds to the active site of the receptor, while the hydrophilic tail binds to leucine residues in the exo-site, which allows it to persist in the active site for a longer period of time. Another hypothesis is that the drug diffuses into the cells of the lungs and provides a depot of drug to the cells over a longer period of time. This helps relax the muscles in the lungs and increases airflow.
When to interrupt dosage
The suggested portion of Advair Hfa is contingent upon the determined condition, such as Exercise-Induced Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD) and Bronchospasm, Exercise-Induced. The amount of dosage changes in view of the approach of application detailed in the table below.Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Asthma
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Bronchospasm, Exercise-Induced
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Exercise-Induced Bronchospasm
, 0.05 mg, 0.021 mg, 0.014 mg, 0.05 mg/pump actuation, 0.014 mg/pump actuation, 0.025 mg/pump actuation, 0.01275 mg
, Oral; Respiratory (inhalation), Powder, metered, Powder, metered - Oral; Respiratory (inhalation), Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Powder - Oral; Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation)
Warnings
Advair Hfa has five contraindications, thus it should not be taken if one is suffering from any of the conditions in the below table.Advair Hfa ContraindicationsCondition
Risk Level
Notes
primary treatment of status asthmaticus
Do Not Combine
Chronic Obstructive Airway Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Salmeterol may interact with Pulse Frequency
Not being treated with an inhaled corticosteroid
Do Not Combine
Asthma
Do Not Combine
Common Advair Hfa Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Salmeterol.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Salmeterol.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Salmeterol.
Aminophenazone
Major
The metabolism of Aminophenazone can be decreased when combined with Salmeterol.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Salmeterol.
Advair Hfa Toxicity & Overdose RiskOverdosing on salmeterol can cause acid buildup in the body, increased lactic acid levels, anxiety, rapid heartbeat, changes in heart rhythm, low potassium levels, and low phosphorus levels. Other symptoms may include seizures, chest pain, high or low blood pressure, irregular heartbeat, headache, muscle cramps, dry mouth, nausea, dizziness, fatigue, and high blood sugar. Treatment may involve intravenous fluids, potassium supplements, a type of medication to protect the heart, and monitoring the patient's heart. There is not enough data available to determine the exact toxicity level for salmeterol.
Advair Hfa Novel Uses: Which Conditions Have a Clinical Trial Featuring Advair Hfa?
244 active trials are currently being conducted to assess the efficacy of Advair Hfa in alleviating Exercise-Induced Bronchospasm, Bronchospasm, Exercise-Induced Bronchospasm and Chronic Obstructive Pulmonary Disease (COPD).Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
99 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4
Bronchospasm, Exercise-Induced
0 Actively Recruiting
Exercise-Induced Bronchospasm
1 Actively Recruiting
Phase 2
Asthma
160 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Advair Hfa Reviews: What are patients saying about Advair Hfa?
5Patient Review
3/28/2010 While this medication did improve my breathing, it unfortunately also caused a drastic and dangerous increase in blood pressure. This made asthma a double-edged sword-- do I die from not being able to breathe or from a stroke? Either way, the high blood pressure prevented me from living a normal life. Other side effects included weight gain, irritability, sudden crying episodes, and overall feelings of sickness.
5Patient Review
10/12/20095Patient Review
8/11/2010 While this medication does work well for me, I have experienced some terrible leg cramps as a result.
5Patient Review
3/1/2013 This medication has helped me breathe better.
4.3Patient Review
11/5/2010 This treatment is really effective. I've tried a lot of different treatments, and this one is by far the best.
4Patient Review
12/4/2012 I needed to use my rescue inhaler a few times soon after taking this drug. I also think it had an effect on my heart rate, which would fluctuate between 40 and 90 beats per minute within a very short period of time.
3.3Patient Review
7/4/2013 I visited a pulmonologist for my shortness of breath and was diagnosed with asthma. He gave me Advair to use, however, the side effects (scratchy throat, muscle aches, coughing) led me to discontinue using it. I then tried Symbicort but experienced a loss of vision in my left eye for 15 minutes; needless to say, that was scary.
3Patient Review
4/27/2011 At first, this treatment worked. But after three days, my throat started to swell gradually. On the fourth day, my tongue and epiglottis muscle (the part that hangs in back of your throat like a pendulum) also swelled. So I stopped using it. Be careful with this drug--it's not subtle at all.
3Patient Review
1/20/2016 While this drug did help me to breathe better, I didn't like the side effects of hoarseness and throat irritation. Three days after discontinuing use, I'm still experiencing these problems.
3Patient Review
6/6/2011 I'm not sure yet, as I've only just started using it.
2.7Patient Review
5/1/2012 I had some serious side effects from this medication, including headaches and muscle cramps. My doctor took me off of it after a short while because the Symbicort was about the same in terms of effectiveness but with far more intense side effects.
2.7Patient Review
3/5/2010 I found that the diskus really aggravated my oral health, to the point where I had to change my diet. Additionally, the dry powder bothered my vocal cords which was a huge issue for me as a singer. The Hfa version is much better in my opinion--the only downside is that you have to take two puffs instead of one.
1.7Patient Review
4/6/2011 While this drug has helped my asthma and COPD, the side effects have been pretty tough to deal with. I've had headaches and problems with my voice box, but they've gotten better since I started taking it regularly.
1.7Patient Review
4/20/2011 Inhalers can be tricky to use, and I often worry that the medication isn't making it to my lungs.
1.7Patient Review
8/16/2012 Unfortunately, this medication caused me some serious vision problems. I had to stop taking it as a result.
Patient Q&A Section about advair hfa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Advair HFA the same as albuterol?
"Fluticasone/salmeterol (Advair) is used to treat asthma and make it easier to breathe. Albuterol (ProAir HFA) is used to quickly stop asthma attacks and help you breathe easier, but it is not for long-term treatment or prevention of asthma since the effects don't last long."
Answered by AI
What is the difference between Advair and Advair HFA?
"ADVAIR DISKUS is a prescription medicine that is used to treat asthma in patients who are four years of age or older. ADVAIR HFA is a prescription medicine that is used to treat asthma in patients who are twelve years of age or older."
Answered by AI
How long does it take Advair HFA to work?
"You may not see the full effects of this drug for a week or longer. Tell your doctor if your symptoms don't improve or get worse."
Answered by AI