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Ibuprofen vs Lodine

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Ibuprofen Details

Lodine Details

Comparative Analysis

Ibuprofen Prescription Information

Lodine Prescription Information

Ibuprofen Side Effects

Lodine Side Effects

Safety Information

Cost Analysis

Market Analysis



For individuals with conditions such as arthritis, musculoskeletal pain or inflammation, certain drugs that inhibit the production of compounds linked to inflammation and pain can help in managing these symptoms. Ibuprofen and Lodine are two such medications often prescribed for these purposes. They both impede the function of cyclooxygenase enzymes involved in producing prostaglandins - substances that cause inflammation, fever, and pain. Ibuprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID), affecting both COX-1 and COX-2 enzymes equally. Lodine, on the other hand, while still classified as an NSAID has more selective action against COX-2 enzyme which results in less gastrointestinal side effects compared to ibuprofen but requires careful monitoring due to potential kidney impact.

Ibuprofen vs Lodine Side By Side

AttributeAdvil motrinLodine
Brand NameAdvil, MotrinLodine
ContraindicationsGastrointestinal issues, recent use of anticoagulants, heart disease, high blood pressure, asthmaGastrointestinal issues, recent use of anticoagulants, heart disease, high blood pressure, asthma
CostApproximately $0.20/day for brand name, as low as $.04 to $.20 per day for genericAround $4–8/day for brand name, starting at roughly $.70/day for generic
Generic NameIbuprofenEtodolac
Most Serious Side EffectStomach or intestinal bleeding, kidney problems, liver issues, rapid heart rate, low red blood cellsHeart problems, liver problems, kidney issues, low red blood cells, allergic reactions
Severe Drug InteractionsAnticoagulantsAnticoagulants
Typical Dose200–800 mg every four to six hours, up to a maximum of 3200 mg/day for adults400–500 mg/day initially, up to 600-1000 mg/day, maximum recommended daily dose is 1200mg

What is Ibuprofen?

Ibuprofen (often sold under brand names such as Advil or Motrin) is a nonsteroidal anti-inflammatory drug (NSAID), which marked a significant development from the first class of pain relief drugs known as opioids. Ibuprofen was first approved by the FDA in 1974. It works by reducing hormones that cause inflammation and pain in the body, making it an effective treatment for various types of discomfort including headaches, minor injuries, toothaches, and menstrual cramps.

Lodine (generic name Etodolac), on the other hand, also belongs to NSAIDs but has been specifically designed for long-term management of arthritis-related symptoms. Approved by the FDA in 1991, Lodine not only helps reduce pain but also inflammation associated with osteoarthritis and rheumatoid arthritis. Compared to Ibuprofen's broad-spectrum application, Lodine offers focused therapy for people suffering from chronic joint conditions while having fewer gastrointestinal side effects than other NSAIDs due to its selective influence on COX-2 enzyme over COX-1.

What conditions is Ibuprofen approved to treat?

Ibuprofen is approved for the treatment of various painful conditions:

  • Mild to moderate pain, such as headaches, toothaches and backaches

  • Menstrual cramps

  • Minor injuries or arthritis

  • Fever reduction In contrast, Lodine (etodolac) is primarily used for managing moderate to severe acute and chronic pain associated with:

  • Osteoarthritis

  • Rheumatoid arthritis

How does Ibuprofen help with these illnesses?

Ibuprofen helps to manage pain and inflammation by inhibiting the production of prostaglandins, chemicals that cause inflammation within the body. It does this by blocking an enzyme known as cyclooxygenase (COX), which is vital for prostaglandin production. Prostaglandins play a significant role in responses like fever, inflammation, and perception of pain. By reducing their amounts in the body, ibuprofen can alleviate these symptoms and help patients manage conditions like arthritis or minor injuries more comfortably.

On the other hand, Lodine (etodolac) works similarly but selectively inhibits COX-2 over COX-1 enzymes. This selective inhibition reduces its gastrointestinal side effects compared to nonselective NSAIDs like Ibuprofen. However, both drugs effectively limit discomfort from inflammatory diseases or injury-induced pain while helping stabilize bodily reactions towards such conditions.

What is Lodine?

Lodine, a brand name for etodolac, is a non-steroidal anti-inflammatory drug (NSAID) that functions by inhibiting cyclooxygenase and reducing the synthesis of prostaglandins. Prostaglandins are compounds in the body that promote inflammation, pain, and fever. Therefore, by stopping their production, Lodine effectively relieves these symptoms. Unlike ibuprofen which can be easily obtained over-the-counter in various forms including tablets and liquids for oral use or topical gels or sprays for skin application, Lodine requires a prescription from your physician.

Etodolac was first approved by the FDA in January 1991. It does not belong to opioid analgesics so it doesn't lead to physical dependence or abuse potential like some pain relievers do. Its lack of opioid action means its side-effect profile is different than those drugs - less risk of addiction but also potentially less effective at managing severe pain compared to opioids. The effect on prostaglandin synthesis can be beneficial for treatment of arthritis-related conditions as well as general pain management especially in patients who don’t respond sufficiently to 'typical' over-the-counter NSAIDs such as ibuprofen.

What conditions is Lodine approved to treat?

Lodine, also known as etodolac, is FDA-approved for managing the following conditions:

  • Osteoarthritis and rheumatoid arthritis - to help manage signs and symptoms such as pain and inflammation.
  • Acute pain - as a powerful NSAID (nonsteroidal anti-inflammatory drug), Lodine can be used to address acute musculoskeletal discomfort or post-operative pain.

How does Lodine help with these illnesses?

Lodine, also known as etodolac, is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing levels of prostaglandins, chemicals responsible for pain and inflammation in the body. It plays roles in many processes such as managing pain and reducing fever or inflammation. Similar to ibuprofen, its action on the cyclooxygenase enzymes (COX-1 and COX-2) hinders these from producing prostaglandins which leads to less swelling and pain. Lodine however tends to cause fewer gastrointestinal side effects compared with other NSAIDs like ibuprofen due to its preferential inhibition of COX-2 over COX-1. Therefore it may be prescribed when patients do not respond well or have adverse reactions towards "typical" NSAIDS such as Ibuprofen.

How effective are both Ibuprofen and Lodine?

Both ibuprofen and etodolac (Lodine) have established histories of effectiveness in managing pain and inflammation due to various conditions, such as arthritis. They were first approved by the FDA within a decade of each other, with ibuprofen being introduced earlier. Since they act on similar pathways but have different chemical structures, they may be prescribed under different circumstances.

The efficacy of both drugs was directly compared in several clinical trials; results showed that ibuprofen and etodolac exhibited comparable efficacy in managing symptoms related to rheumatoid arthritis or osteoarthritis. In these studies, none of the parameters used to measure relief from pain or reduction in inflammation significantly differed between patients receiving ibuprofen and those receiving etodolac.

A review published in 2003 reported that ibuprofen is effective for providing short-term relief from acute pain starting from the first dose, its side effect profile is less severe than many older NSAIDs (non-steroidal anti-inflammatory drugs), and it's well-tolerated across a broad range of populations including children and the elderly. Ibuprofen has become one of the most widely-used over-the-counter medications worldwide for mild to moderate pain relief.

On the other hand, a meta-analysis conducted in 2016 indicated that etodolac seems more effective than placebo at treating chronic joint-related conditions like osteoarthritis or rheumatoid arthritis. It appears to be similar in efficacy when compared with other common NSAIDs. Due to its unique pharmacology - namely selective inhibition of cyclooxygenase-2 (COX-2) which leads less gastrointestinal side effects - Lodine may be an optimal choice for patients who require long-term management for chronic arthritic conditions or are at risk for peptic ulcer disease caused by non-selective NSAIDs.

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At what dose is Ibuprofen typically prescribed?

Oral dosages of Ibuprofen for adults typically range from 200–800 mg every four to six hours, depending on the severity of the pain. However, a lower dosage of 200-400mg can be sufficient for mild to moderate pain relief in most cases. For children and adolescents, the dosage is typically based on weight rather than age, with 10 mg/kg being advised. If there's no adequate response or if symptoms persist after a few days despite treatment, you should consult your doctor immediately. The maximum daily dose that should not be exceeded is 3200 mg/day for adults and depends on weight (40 mg/kg) for children.

On the other hand, Lodine (etodolac) has a typical starting dose in adults ranging from 400-500mg twice per day up to three times per day as required but studies have shown that around 600mg once per day or split into two doses (300mg each) may be enough for managing milder forms of osteoarthritis-related pain or rheumatoid arthritis in most people. Dosage adjustments are usually considered after several weeks if there is no satisfactory response to treatment without exceeding the maximum recommended daily dose which stands at 1000 mg/day.

At what dose is Lodine typically prescribed?

Lodine (etodolac) treatment is typically initiated at a dosage of 400–500 mg/day, taken orally. The dose can then be increased to 600-1000 mg/day, divided into two doses, spaced approximately 12 hours apart. The maximum recommended daily dose for Lodine is 1200mg and this may be considered if there is no adequate response to the initial treatment after several weeks. Similar to other NSAIDs such as ibuprofen or aspirin, Lodine has potential side effects including stomach upset and bleeding risks; therefore it should always be used under the guidance of a healthcare professional.

What are the most common side effects for Ibuprofen?

Common side effects of Ibuprofen compared to Lodine can include:

  • Upset stomach, mild heartburn, nausea or vomiting
  • Bloating, gas, diarrhea or constipation
  • Dizziness, nervousness or headache
  • Mild itching or rash
  • Ringing in your ears

While Lodine may cause similar side effects as ibuprofen such as upset stomach and dizziness. Other potential side effects unique to Lodine could be:

  • Dry mouth
  • Unusual tiredness
  • Swelling of hands/ankles/feet (edema)

It's worth noting that both drugs should be taken with caution if you have kidney disease, liver disease, heart disease or a history of stomach ulcers. Always remember it's essential to discuss any new medication with your healthcare provider who knows your medical history and other medications you are taking.

abstract image of a patient experiencing side effect

Are there any potential serious side effects for Ibuprofen?

While both ibuprofen and Lodine (etodolac) are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain, inflammation, and fever, they may have different side effects. Some potential adverse reactions include:

  • An allergic reaction that can cause hives; difficulty breathing; swelling of your face, lips, tongue or throat
  • Stomach or intestinal bleeding: signs could be bloody or tarry stools, coughing up blood or vomit that resembles coffee grounds
  • Kidney problems: little or no urination; painful or difficult urination; swelling in your feet or ankles
  • Liver issues: nausea; upper stomach pain; itching tiredness; flu-like symptoms loss of appetite dark urine clay-colored stools jaundice
  • Rapid heart rate with chest fluttering and possible feelings of dizziness as if you might faint
  • Low red blood cells causing fatigue pale skin light-headedness shortness of breath rapid heart rate trouble concentrating

If any such symptoms occur while taking either medication it is advised to discontinue use immediately and contact a healthcare professional.

What are the most common side effects for Lodine?

Common side effects of Lodine include:

  • Headache, dizziness
  • Upset stomach or throwing up
  • Stomach pain or cramps
  • Diarrhea or constipation
  • Indigestion or heartburn
  • Gas
  • Sweating a lot These symptoms are usually mild and short-lived. However, some people can experience severe reactions such as chest pain, unexplained weight gain, difficulty breathing and swallowing, swelling of the hands or feet. Always consult your healthcare provider if you experience any unusual side effects while taking Lodine.

Are there any potential serious side effects for Lodine?

Lodine, similar to other nonsteroidal anti-inflammatory drugs (NSAIDs), can potentially cause serious side effects in some instances. These adverse effects may include:

  • Signs of an allergic reaction such as hives, difficult breathing, swelling in your face or throat
  • Symptoms related to heart problems like chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech and shortness of breath
  • Liver problems that manifest as nausea, upper stomach pain, fatigue and jaundice (yellowing of the skin or eyes)
  • Kidney issues with symptoms including little or no urination; painful or difficult urination; swelling in your feet or ankles; feeling tired
  • Low red blood cells (anemia) resulting in pale skin, unusual tiredness and feeling light-headed If you experience any of these serious side effects while taking Lodine it's important that you consult a healthcare professional immediately.

Contraindications for Ibuprofen and Lodine?

Both ibuprofen and Lodine (etodolac), like other nonsteroidal anti-inflammatory drugs (NSAIDs), may exacerbate symptoms in individuals with gastrointestinal issues. If you notice your symptoms worsening, such as an increase in stomach pain, bloody stools, or changes in bowel habits, please seek immediate medical attention.

Neither ibuprofen nor Lodine should be taken if you are using or have recently used anticoagulants. Always inform your physician about any medications you're currently taking; anticoagulants will require a certain period to clear from the system to prevent dangerous interactions with ibuprofen and Lodine.

Additionally, people who suffer from heart disease or high blood pressure should use these drugs cautiously as they can cause fluid retention leading to edema and potentially worsening heart conditions. It's also important for patients with asthma to consult their healthcare provider before starting treatment as NSAIDs can trigger an attack.

How much do Ibuprofen and Lodine cost?

For the brand name versions of these drugs:

  • The price for 100 tablets of Lodine (400 mg) averages around $200, which works out to about $4–8/day depending on your dose.
  • The cost for a bottle of 50 Advil tablets (200 mg ibuprofen each) is typically about $10, which amounts to approximately $0.20/day.

If you are in the higher dosage range for Lodine (i.e., 1200 mg/day or higher), then branded ibuprofen such as Advil would be less expensive on a per-day treatment basis. However, keep in mind that cost should not be your primary consideration when deciding between these two medications.

For generic etodolac and ibuprofen, costs can be significantly lower:

  • Generic etodolac is available in packs from 30 up to 60 capsules (400 mg), with daily costs starting at roughly $.70/day if you take typical doses ranging from 600 to 1000mg/day.
  • Generic ibuprofen comes in various pack sizes with dosages ranging from 200mg up to an over-the-counter maximum of 800mg daily. Costs start as low as $.04 per day and do not exceed more than $.20 per day. These values may vary slightly based on location and store but generally stay within this range.

Popularity of Ibuprofen and Lodine

Ibuprofen, both in its generic form and under brand names such as Advil and Motrin, was prescribed to about 21 million people in the US in 2020. Ibuprofen accounted for just over 22% of NSAID (Non-Steroidal Anti-Inflammatory Drugs) prescriptions in the US. It is a widely used medication for its analgesic, anti-inflammatory, and antipyretic properties.

Etodolac, often known by the brand name Lodine, had significantly fewer prescriptions compared to ibuprofen with nearly 1 million scripts written in the USA during 2020. In terms of NSAIDs prescription counts within the United States market share it takes up around 2%. Etodolac is primarily used for pain associated with osteoarthritis or rheumatoid arthritis but has less common use due to potential side effects including stomach ulcers/bleeding. Despite this risk being common amongst most NSAIDs etodolac appears more liable than others like ibuprofen.


Both ibuprofen and Lodine (etodolac) have a long-standing record of usage in patients with inflammation, pain, and fever. They are well-supported by numerous clinical studies indicating that they are more effective than placebo treatments for these conditions. Both drugs belong to the class of non-steroidal anti-inflammatory drugs (NSAIDs), but their mechanisms differ slightly: ibuprofen inhibits both COX-1 and COX-2 enzymes involved in prostaglandin production, while etodolac is selective for COX-2.

Ibuprofen is generally considered first-line treatment due to its safety profile, wide availability over-the-counter, and lower cost. Etodolac would usually be considered as an alternative or add-on therapy when ibuprofen is not sufficient or if there's a particular need to reduce gastrointestinal side effects associated with NSAIDs.

Both drugs come in generic form which represents significant cost savings especially for patients who must pay out-of-pocket. As with any medication, it may take some time before the full therapeutic effects can be observed.

The side effect profiles between the two drugs are similar; however etodolac being a selective inhibitor of COX-2 might carry less risk of certain gastrointestinal side effects than ibuprofen. For both medications, patients should monitor for any adverse symptoms such as abdominal pain or blood in stools and seek medical help immediately if they occur.