Weight-Bearing CT Scans for Periprosthetic Fractures
Trial Summary
What is the purpose of this trial?
Total knee arthroplasty (TKA) is a surgical procedure commonly conducted for patients with end-stage knee osteoarthritis, often leading to improved pain relief and function. However, for patients that have suffered an associated periprosthetic fracture, a broken bone that occurs around the implant of a TKA, they may receive sub-optical care due to a lack of a trustworthy assessments for component fixation and fracture healing in the literature. The prevalence of TKA surgeries is increasing annually and is projected to rise further due to an ageing population and obesity issue. By extension to this primary surgery, more Canadians will require an invasive revision surgery that risks patient morbidity and mortality. Thus, it is imperative to set a standard for fixation and bone healing assessments to lessen revision burdens and improve patient outcomes. CT imaging can effectively visualize areas of incomplete bone ingrowth that may be hidden from overlapping anatomy on plain radiographs, which remains the go-to imaging modality for orthopaedic surgeons to assess periprosthetic fracture healing. The purpose of this prospective cross-sectional study is to examine the efficacy of weight-bearing CT as a diagnostic tool for 20 participants who experienced a distal femur periprosthetic fracture and underwent revision surgery using a fracture fixation plate and screws. Participants will be scanned under loaded and unloaded conditions. Radiographic outcomes will be evaluated, including bone segment displacement and its relation to participants' reports of pain.
Research Team
Matthew Teeter, PhD
Principal Investigator
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Brent Lanting, MD
Principal Investigator
Lawson Health Sciences Centre
Lyndsay Somerville, PhD
Principal Investigator
London Health Sciences Centre
Patrick J Mixa, MD
Principal Investigator
Western University
James Howard, MD
Principal Investigator
London Health Sciences Centre
Eligibility Criteria
This trial is for individuals who have had a total knee replacement and later suffered from a periprosthetic fracture near the implant. Participants should be those who underwent revision surgery with fixation plates and screws, willing to undergo CT scans under different conditions.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo weight-bearing and conventional CT scans to assess bone displacement under loading conditions
Follow-up
Participants are monitored for safety and effectiveness after CT scans, with outcome measures assessed through questionnaires
Treatment Details
Interventions
- Weight-Bearing CT
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Who Is Running the Clinical Trial?
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor