← Back to Search

Probiotic

Probiotics for Vascular Aging

N/A

Recruiting

Led By Michael E Widlansky, MD

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

For women: 12 months or more since last menstruation

Ages 50-99 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 weeks

Awards & highlights

Study Summary

This trial will test whether a probiotic can help reverse vascular aging in healthy older adults.

Who is the study for?

This trial is for healthy older adults aged 50-99 who have not had a menstrual period in at least 12 months (if female), do not smoke, and are free from diabetes, high cholesterol, cognitive impairments, hypertension treatments, excessive alcohol use, and certain chronic diseases. They should also be inactive (averaging less than 7500 steps per day).Check my eligibility

What is being tested?

The study tests if Lactobacillus Plantarum 299v in a fermented oat drink can reverse signs of vascular aging compared to a placebo control drink. It's aimed at older adults without cardiovascular disease or risk factors.See study design

What are the potential side effects?

While the side effects aren't detailed here, probiotics like Lp299v may cause digestive discomfort such as gas or bloating initially. Long-term side effects are unknown which is part of what the study aims to discover.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have not had a period in the last 12 months or more.

Select...

I am between 50 and 99 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brachial Artery Flow Mediated Dilation (FMD%

Secondary outcome measures

Brachial Artery Resting Diameter

Carotid-Femoral Pulse Wave Velocity (cfPWV)

Hyperemic Flow Velocity

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Lp299vExperimental Treatment1 Intervention

Subjects will consume 20 billion colony forming units of Lp299v (1 serving of GoodBelly fermented oat drink) once daily for 6 weeks

Group II: Heat-killed placebo controlPlacebo Group1 Intervention

Subjects will consume 1 serving of GoodBelly fermented oat drink that has been treated to heat kill all Lp299v once daily for 6 weeks

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor

609 Previous Clinical Trials

1,162,563 Total Patients Enrolled

Michael E Widlansky, MDPrincipal InvestigatorMedical College of Wisconsin

2 Previous Clinical Trials

41 Total Patients Enrolled

Media Library

Lactobacillus Plantarum 299v in fermented oat drink (Probiotic) Clinical Trial Eligibility Overview. Trial Name: NCT05296395 — N/A

Vascular Aging Research Study Groups: Lp299v, Heat-killed placebo control

Vascular Aging Clinical Trial 2023: Lactobacillus Plantarum 299v in fermented oat drink Highlights & Side Effects. Trial Name: NCT05296395 — N/A

Lactobacillus Plantarum 299v in fermented oat drink (Probiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05296395 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is eligibility for this research restricted to seniors aged 85 or younger?

"This clinical trial is designed specifically for individuals aged 50 to 99. There are additional trials available outside of this range, with one option focussing on minors and another catering towards seniors."

Answered by AI

What type of participants are best suited for this experiment?

"A total of 20 individuals with vascular aging aged between 50 and 99 years old may be enrolled in this study. Notably, female participants must not have had a menstrual period within the last 12 months."

Answered by AI

Are researchers currently enrolling volunteers for this investigation?

"According to clinicaltrials.gov, this trial has not been actively seeking participants since October 11th 2022, when the most recent update was posted. Nevertheless, there are two other trials that urgently need volunteers right now."

Answered by AI

Recent research and studies

CellJournal

Mining the Human Gut Microbiota for Immunomodulatory Organisms

Geva-Zatorsky, Naama, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, et al.. 2017. “Mining the Human Gut Microbiota for Immunomodulatory Organisms”. Cell. Elsevier BV. doi:10.1016/j.cell.2017.01.022.

The Journal of ImmunologyJournal

Leptin-induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-kinase, Akt, Nf-κb, and P300 Pathway in Microglia

Tang, Chih-Hsin, Da-Yuu Lu, Rong-Sen Yang, Huei-Yann Tsai, Ming-Ching Kao, Wen-Mei Fu, and Yuh-Fung Chen. 2007. “Leptin-induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-kinase, Akt, Nf-κb, and P300 Pathway in Microglia”. The Journal of Immunology. The American Association of Immunologists. doi:10.4049/jimmunol.179.2.1292.

CellJournal

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Schirmer, Melanie, Sanne P. Smeekens, Hera Vlamakis, Martin Jaeger, Marije Oosting, Eric A. Franzosa, Rob ter Horst, et al.. 2016. “Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity”. Cell. Elsevier BV. doi:10.1016/j.cell.2016.10.020.

DiabetesJournal