Xenon MRI for Lung Cancer
((XeRTLC) Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if xenon-enhanced MRI scans can improve radiation therapy planning for lung cancer patients. By highlighting well-functioning lung areas, the scans may help direct treatment away from these regions, potentially preserving lung function. Lung cancer patients planning to undergo standard stereotactic body radiation therapy (a focused radiation treatment) are suitable candidates for this study. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to advancements in lung cancer care.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. However, if you are receiving cancer treatment with certain agents like immunotherapy or chemotherapy, you may not be eligible to participate.
What prior data suggests that Xenon MRI is safe for lung cancer patients?
Research has shown that Xenon MRI safely and effectively examines lung function. This imaging method assesses lung performance and gas exchange. In studies with patients who had lung diseases, Xenon MRI caused no serious side effects or harm. This makes it a promising tool for guiding lung cancer treatment without adding extra risk.12345
Why are researchers excited about this trial?
Researchers are excited about using Xenon MRI for lung cancer treatment because it offers a new way to visualize lung function, which could lead to more precise radiation therapy. Unlike traditional imaging techniques, Xenon MRI allows doctors to see how different parts of the lung are functioning, not just what they look like. This means treatments can be adapted to avoid highly functional lung areas, potentially reducing damage to healthy tissue. By tailoring radiation plans more accurately, this approach could improve outcomes and quality of life for lung cancer patients.
What evidence suggests that xenon MRI is effective for lung cancer?
Research has shown that xenon MRI is a promising tool for assessing lung function. It is safe and effectively measures how well the lungs breathe, exchange gases, and their structure. It has been successfully used in patients with lung conditions like asthma and COPD (chronic obstructive pulmonary disease). In lung diseases, it aids in understanding the condition and monitoring treatment effectiveness. In this trial, xenon MRI will guide radiation therapy in lung cancer patients. Participants in the Technical Development Arm will undergo standard-of-care stereotactic body radiation therapy (SBRT), while those in the Implementation Arm will receive SBRT plans functionally adapted to avoid highly functioning lung areas based on xenon MRI. This approach could potentially improve treatment results for lung cancer patients.34678
Who Is on the Research Team?
Sean Fain, PhD
Principal Investigator
University of Iowa
Are You a Good Fit for This Trial?
This trial is for individuals with a clinical diagnosis of lung cancer, intending to undergo stereotactic body radiation therapy. Participants must be able and willing to give informed consent and follow the study's schedule.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation Therapy
Participants undergo stereotactic body radiation therapy (SBRT) with functional adaptation using Xe MRI to avoid highly functioning lung regions
Follow-up
Participants are monitored for safety and effectiveness after treatment, including lung function changes and radiation pneumonitis
What Are the Treatments Tested in This Trial?
Interventions
- Xenon MRI
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sean Fain
Lead Sponsor