Memory Retraining for Cognitive Impairment

Age: 65+
Sex: Any
Trial Phase: Academic
Sponsor: Kessler Foundation

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests memory retraining exercises to determine their effectiveness in improving memory for healthy older adults and those with mild cognitive impairment (MCI). Researchers aim to discover if these exercises can significantly impact daily life and brain activity. Participants will either engage in the memory exercises or perform similar activities without a memory focus for comparison. The trial seeks English-speaking individuals over 65 who do not have specific neurological or psychiatric conditions. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could enhance memory health for many.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the modified Story Memory Technique is safe for cognitive impairment?

Research has shown that memory retraining exercises, like those in this trial, are generally safe. Studies have found these exercises helpful and well-tolerated. For instance, one study discovered that brain training exercises can reduce the risk of memory problems and dementia, indicating their safety over time.

Moreover, similar brain training methods have been used without reports of serious side effects. Participants in the trial are unlikely to face major negative effects from the memory retraining exercises. However, individual experiences can differ. Always consult a healthcare provider before joining any clinical trial.12345

Why are researchers excited about this trial?

Researchers are excited about memory retraining exercises for cognitive impairment because they offer a fresh, non-drug approach to improving memory. Unlike traditional treatments that often rely on medications to manage symptoms, these exercises focus on enhancing cognitive function through targeted mental activities. This method is delivered digitally, making it accessible and easy to integrate into daily routines. By engaging the brain in structured exercises, there’s potential for significant improvement in cognitive abilities without the side effects associated with pharmaceuticals.

What evidence suggests that memory retraining exercises could be effective for cognitive impairment?

Research has shown that memory retraining exercises, which participants in this trial may receive, can improve memory in adults. A review of studies found that these exercises lead to noticeable improvements in memory. Another study suggested that these exercises might boost the production of brain chemicals related to memory and attention. These findings indicate that memory retraining exercises could benefit people with mild cognitive impairment (MCI). Overall, the evidence suggests that these exercises could positively affect memory and thinking skills.678910

Who Is on the Research Team?

ND

Nancy D Chiaravalloti, PhD

Principal Investigator

Kessler Foundation

Are You a Good Fit for This Trial?

This trial is for individuals over the age of 65 who primarily speak English. It's designed to help those experiencing mild cognitive impairment or general issues with memory and cognition due to aging.

Inclusion Criteria

primary language is English.
I am older than 65.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo baseline cognitive assessment to determine allocation to HA or MCI block

1 week
1 visit (in-person)

Treatment

Participants receive 10 sessions of mSMT or placebo memory exercises over 5 weeks

5 weeks
10 visits (virtual)

Immediate Post-Treatment Assessment

Assessment of new learning and memory abilities immediately after treatment

1 week
1 visit (in-person)

Follow-up

Participants are monitored for long-term impact on learning and memory abilities

6 years
Assessments at 6 months, 1 year, 2 years, and 6 years post-treatment

What Are the Treatments Tested in This Trial?

Interventions

  • Memory retraining exercises
  • Placebo control memory exercises
Trial Overview The study tests the modified Story Memory Technique (mSMT), a memory retraining exercise, against placebo control exercises. Participants will be randomly assigned to either group in a double-blind setup, meaning neither they nor the researchers know who's receiving which treatment.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Experimental GroupExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Kessler Foundation

Lead Sponsor

Trials
190
Recruited
11,300+

Citations

Brain function effects of exercise interventions for cognitive ...It is well reported that exercise (aerobic, resistance or tai-chi) can improve cognition in older adults with and without cognitive decline ( ...
Brain training game boosts chemical linked to memory and ...A new study finds that a cognitive training program may boost production of a brain chemical that plays a role in memory and attention.
Comparative efficacy of exercise interventions for cognitive ...Highlights. Resistance training was found to have the greatest impact on overall cognitive improvement and inhibitory control. Aerobic exercise showed the ...
Effectiveness of exercise interventions to improve long ...A growing body of literature reports that exercise and physical activity (EXPA) can slow down the onset of dementia and prevent problems ...
Cognitive and memory training in adults at risk of dementiaOur systematic review found that cognitive exercises can produce moderate-to-large beneficial effects on memory-related outcomes.
Memory support training and lifestyle modifications to ...Combining training in lifestyle modification and memory support strategies may confer synergistic benefits.
Making Physical Activity Accessible to Older Adults With ...Purpose: For individuals with mild cognitive impairment (MCI), memory loss may prevent successful engagement in exercise, a key factor in preventing additional ...
Can Brain Training Lower Your Risk of Dementia?After 10 years, people assigned to the speed-of-processing training had a 33 percent lower incidence of cognitive impairment and dementia than ...
Even Light Exercise Could Help Slow Cognitive Decline in ...Overall, the findings of both studies taken together suggest that exercise may be a promising, safe and feasible strategy to promote brain ...
Physical exercise attenuates cognitive decline and reduces ...Physical exercise can reduce global cognitive decline and lessen behavioural problems in people with MCI or dementia.
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