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Radiation

Stereotactic Radiosurgery for Brain Aneurysm (BLAST Trial)

N/A

Recruiting

Led By David Mathieu, MD FRCS(C)

Research Sponsored by Dr David Mathieu

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Medical imaging (CTA, MRA or digital subtraction angiography) reveals the existence of an asymptomatic unruptured saccular anterior circulation intracranial aneurysm under 7 mm

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

BLAST Trial Summary

This trial tests if radiosurgery is safe and effective for low-risk brain aneurysms in humans. Participants will be monitored for 3 years to confirm safety.

Who is the study for?

This trial is for people with small, unruptured brain aneurysms in the front part of the brain who've been advised to just watch it instead of getting surgery. They shouldn't have symptoms from the aneurysm, previous treatments on it, or conditions that make follow-ups hard.Check my eligibility

What is being tested?

The study tests if using Stereotactic RadioSurgery (SRS) on these low-risk aneurysms is safe and doesn't increase rupture risk compared to just watching them. Participants can choose SRS or observation and are followed up for three years with scans and questionnaires.See study design

What are the potential side effects?

Potential side effects aren't detailed here but could include typical risks associated with radiosurgery such as localized pain, swelling, skin redness, fatigue, headaches or changes in brain function depending on treatment area.

BLAST Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have a small, unruptured brain aneurysm detected by imaging.

BLAST Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Between group difference in the incidence of aneurysm rupture during the study period

Secondary outcome measures

Aneurysm occlusion confirmed by CT-angiography (CTA)

Change in aneurysm shape indices relative to baseline

Change in aneurysm volume relative to baseline

+2 more

BLAST Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: SRS groupExperimental Treatment1 Intervention

Participants in the SRS group will receive the intervention described earlier, consisting of a Gamma Knife radiosurgery, and undergo the same follow-up exams (radiological and clinical) as participants of the control group.

Group II: Control groupActive Control1 Intervention

The medical care will consist of observation for any element that may indicate an increased risk of rupture, like aneurysm growth or instability in shape.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Université de SherbrookeOTHER

293 Previous Clinical Trials

69,475 Total Patients Enrolled

Dr David MathieuLead Sponsor

Centre de recherche du Centre hospitalier universitaire de SherbrookeOTHER

58 Previous Clinical Trials

31,125 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals who are younger than 40 years old authorized to join this research?

"Qualified participants for this trial must be between 18 and 75 years of age."

Answered by AI

Am I eligible to register for this experiment?

"This medical trial is looking to recruit 40 patients with brain aneurysm who are aged between 18 and 75."

Answered by AI

What is the approximate number of research participants being accepted into this trial?

"Affirmative. As evidenced on clinicaltrials.gov, this medical investigation is currently recruiting participants - a process which began on 10th January 2023 and was recently updated on 15th September 2023. The research necessitates 40 volunteers from one facility."

Answered by AI

Is this investigation actively seeking new participants?

"Affirmative, according to the information on clinicaltrials.gov this investigation is actively seeking participants. The trial was published on October 1st 2023 and its most recent update was September 15th 2023. 40 individuals are needed at a single medical establishment for the study's completion."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial

Dr David Mathieu 2023. "Brain Low-risk Aneurysm Stereotactic Radiosurgical Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06047951.