Zubsolv

Pain, Itching, Septic Shock + 7 more

Treatment

8 FDA approvals

20 Active Studies for Zubsolv

Treatment for

Pain

What is Zubsolv

Naloxone

The Generic name of this drug

Treatment Summary

Buprenorphine is a medication used to treat severe pain and opioid addiction. It is sold under the name Suboxone and is formulated with naloxone, a drug that blocks the effects of opioids if injected. Buprenorphine is taken sublingually (under the tongue) and works by binding to opioid receptors in the brain to reduce pain or withdrawal symptoms. It has a long-lasting effect and can be taken once a day, which reduces the risk of overdose or side effects. Buprenorphine is also used in Opioid Agonist Treatment (OAT) or Opioid Subst

Narcan

is the brand name

image of different drug pills on a surface

Zubsolv Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Narcan

Naloxone

1971

241

Approved as Treatment by the FDA

Naloxone, otherwise called Narcan, is approved by the FDA for 8 uses including Pain and Opioid Dependence .

Pain

Used to treat moderate Pain in combination with Pentazocine

Opioid Dependence

Used to treat Opioid Dependence in combination with Buprenorphine

Septic Shock

Pain

Used to treat Severe Pain in combination with Pentazocine

Opioid-Related Disorders

Used to treat Opioid Dependence in combination with Buprenorphine

Septic Shock

Opioids

Respiratory Insufficiency

Effectiveness

How Zubsolv Affects Patients

Buprenorphine is an opioid painkiller that works by binding to mu-receptors in the brain, spine, and other parts of the body. It can produce feelings of relaxation, euphoria, and drowsiness, as well as reduce coughs and shrink pupil size. Taking buprenorphine for a long period of time can lead to physical dependence, with withdrawal symptoms when it is stopped suddenly. It can also cause significant respiratory depression and even death if taken in large doses or when combined with other substances like benzodiazepines or alcohol. Buprenorphine can cause constipation, decreased sex drive

How Zubsolv works in the body

Buprenorphine is a drug that binds to the same nerve receptors as other opioids, like heroin, oxycodone and methadone. However, it doesn't activate these receptors as much as these other opioids, which means it has a slower onset and a "ceiling effect" - a point at which the effects of the drug stop increasing. This makes it less likely to cause overdose, and the lower activation of the receptors means it doesn't cause as much sedation or euphoria. Buprenorphine can cause a rapid withdrawal if taken by someone who's already dependent on opioids, so it's important that they

When to interrupt dosage

The measure of Zubsolv depends on the diagnosed affliction, including Pain, Pain and Opioid Dependence. The quantity of dosage likewise varies as indicated by the method of delivery (e.g. Tablet - Oral or Sublingual) specified in the table beneath.

Condition

Dosage

Administration

Opioids

, 0.4 mg/mL, 1.0 mg/mL, 0.5 mg, 2.0 mg, 0.4 mg, 40.0 mg/mL, 4.0 mg, 20.0 mg/mL, 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg, 1.0 mg, 3.0 mg, 2.9 mg, 0.36 mg, 0.71 mg, 1.4 mg, 2.1 mg, 0.18 mg, 0.7 mg, 0.3 mg, 4.0 mg/mL, 0.02 mg/mL, 1.8 mg, 80.0 mg/mL, 50.0 mg/mL

, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Parenteral, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Oral, Tablet, Tablet - Oral, Sublingual, Tablet - Sublingual, Film, soluble, Film, soluble - Sublingual, Intramuscular; Subcutaneous, Injection, solution - Intramuscular; Subcutaneous, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid, Solution - Intramuscular; Intravenous; Subcutaneous, Solution, Nasal, Spray, Spray - Nasal, Tablet, extended release, Tablet, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray, metered, Spray, metered - Nasal, Film, Film - Buccal, Buccal, Pill - Sublingual, Pill, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Intravenous, Injection - Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Parenteral; Topical, Inhalant, Inhalant - Nasal

Itching

Opioid-Related Disorders

Septic Shock

Respiratory Insufficiency

Opioids

Pain

Emergency Care

Opioids

Pain

Warnings

Zubsolv has twenty-two contraindications and should not be ingested when enduring any of the ailments outlined in the subsequent table.

Zubsolv Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Naloxone may interact with Pulse Frequency

There are 20 known major drug interactions with Zubsolv.

Common Zubsolv Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Naloxone.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Naloxone.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Naloxone.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Naloxone.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Naloxone.

Zubsolv Toxicity & Overdose Risk

Signs of an acute overdose of morphine include small pupils, drowsiness, low blood pressure, and difficulty breathing. If left untreated, it can lead to death.

image of a doctor in a lab doing drug, clinical research

Zubsolv Novel Uses: Which Conditions Have a Clinical Trial Featuring Zubsolv?

Currently, 21 active studies are assessing the potential of Zubsolv for treating Opioid Dependence, Pain and Palliative Care.

Condition

Clinical Trials

Trial Phases

Emergency Care

0 Actively Recruiting

Opioids

0 Actively Recruiting

Opioid-Related Disorders

0 Actively Recruiting

Septic Shock

0 Actively Recruiting

Respiratory Insufficiency

0 Actively Recruiting

Itching

2 Actively Recruiting

Phase 3, Not Applicable

Pain

0 Actively Recruiting

Opioids

7 Actively Recruiting

Phase 4, Not Applicable, Phase 2, Phase 1

Opioids

6 Actively Recruiting

Phase 2, Not Applicable, Early Phase 1, Phase 4

Pain

0 Actively Recruiting

Zubsolv Reviews: What are patients saying about Zubsolv?

Patient Review

4/6/2017

Zubsolv for Narcotic Addiction

Zubsolv has been a game-changer for me. I was on suboxone twice before and relapsed both times, but this third time feels different. Zubsolv doesn't make me feel as terrible as suboxone did, and I'm finally starting to see progress in my recovery.

Patient Review

4/7/2017

Zubsolv for Prevention of Opiate Drug Abuse

I feel like this drug has helped me more than any other I've tried. Zubsolv is definitely the way to go if you're looking to get off drugs.

Patient Review

7/30/2014

Zubsolv for Narcotic Addiction

I switched from Sub to Zub on 7/1/14 when my insurance stopped covering the former. I find Zub WAY more effective: it tastes better, dissolves faster, and gets into my bloodstream quickly. I was on 16mg Sub and now 10mg of Zub and can tell NO difference. The only downside is that it's hard to open the package.

Patient Review

5/1/2019

Zubsolv for Prevention of Opiate Drug Abuse

This medication has been integral in my sobriety. It curbs cravings and helps me feel more confident about my ability to stay clean. I highly recommend it to anyone who is addicted or trying to stay sober.

Patient Review

12/11/2019

Zubsolv for Narcotic Addiction

These pills have completely changed my life for the better. I highly recommend them to anyone struggling with addiction.

4.7

Patient Review

7/31/2015

Zubsolv for Narcotic Addiction

I've been on zubsolv for almost a year now and I much prefer it to sub. To me, it lasts longer and tastes better. Additionally, I get a bit of a rush from it unlike sub which made me incredibly tired. The only problem with zub is that my pharmacy isn't always well-stocked with it.

Patient Review

7/31/2017

Zubsolv for Narcotic Addiction

Suboxone is my preferred treatment, but Zubsolv works just as well. The only downside is that the tablets are not as easy to use as the strips.

1.7

Patient Review

11/11/2022

Zubsolv for Chronic Pain

Subutol was a terrible experience for me. It made my headaches and muscle pain in my legs worse, sapped all my energy, and made it hard to get out of bed or focus on anything. I got back on Suboxone and within two days felt one hundred percent better.

1.3

Patient Review

8/3/2015

Zubsolv for Chronic Pain

Suboxone was a huge disappointment. I experienced intense water retention, raw tongue and swelling, lethargy, lack of energy, withdrawal symptoms, no pain relief, vision problems, constipation, irritability, and difficulty opening the packaging.

Patient Review

1/18/2015

Zubsolv for Prevention of Opiate Drug Abuse

I was recently switched to Zubsolv because my insurance stopped covering name brand Suboxone films and then the generic Suboxone tablets. I hate the minty taste and i've been depressed since switching last week. I have been having trouble sleeping and for the first time in years i'm experiencing withdrawls again.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zubsolv

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Zubsolv?

"You may experience the following symptoms: dizziness, drowsiness, blurred vision, feeling drunk, trouble concentrating, withdrawal symptoms, tongue pain, redness or numbness inside your mouth, nausea, vomiting, constipation, headache, back pain, fast or pounding heartbeats, increased sweating, or sleep problems (insomnia)."

Answered by AI

How does Zubsolv make you feel?

"However, people taking buprenorphine in studies have reported some emotional side effects, such as anxiety, depression, and nervousness. Additionally, people going through withdrawal may also experience these emotions. withdrawal from buprenorphine can cause anxiety."

Answered by AI

What is Zubsolv used for?

"Naloxone reverses the effects of opioids and can cause withdrawal symptoms in people who take opioids.

This drug is a combination of two medicines, buprenorphine and naloxone, and is used to treat dependence or addiction to opioids. Buprenorphine is a drug that belongs to a class of mixed opioid agonist-antagonists, meaning that it helps to prevent withdrawal symptoms caused by quitting other opioids. Naloxone, on the other hand, reverses the effects of opioids and can actually cause withdrawal symptoms in people who take opioids regularly."

Answered by AI

Does Zubsolv have Narcan in it?

"Zubsolv contains two active drugs: buprenorphine and naloxone. Zubsolv comes in six strengths, which contain different amounts (in milligrams) of the drugs. The lowest strength contains 0.7 mg of buprenorphine and 0.18 mg of naloxone."

Answered by AI