What is Zubsolv
BuprenorphineThe Generic name of this drug
Treatment SummaryBuprenorphine is a medication used to treat severe pain and opioid addiction. It is sold under the name Suboxone and is formulated with naloxone, a drug that blocks the effects of opioids if injected. Buprenorphine is taken sublingually (under the tongue) and works by binding to opioid receptors in the brain to reduce pain or withdrawal symptoms. It has a long-lasting effect and can be taken once a day, which reduces the risk of overdose or side effects. Buprenorphine is also used in Opioid Agonist Treatment (OAT) or Opioid Subst
Buprenexis the brand name
Zubsolv Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261
Approved as Treatment by the FDA
Buprenorphine, commonly known as Buprenex, is approved by the FDA for 2 uses which include Psychosocial Treatment and Opioid Dependence .Psychosocial Treatment
Used to treat Psychosocial Treatment in combination with Naloxone
Opioid Dependence
Used to treat Opioid Dependence in combination with Naloxone
Effectiveness
How Zubsolv Affects PatientsBuprenorphine is an opioid painkiller that works by binding to mu-receptors in the brain, spine, and other parts of the body. It can produce feelings of relaxation, euphoria, and drowsiness, as well as reduce coughs and shrink pupil size. Taking buprenorphine for a long period of time can lead to physical dependence, with withdrawal symptoms when it is stopped suddenly. It can also cause significant respiratory depression and even death if taken in large doses or when combined with other substances like benzodiazepines or alcohol. Buprenorphine can cause constipation, decreased sex drive
How Zubsolv works in the bodyBuprenorphine is a drug that binds to the same nerve receptors as other opioids, like heroin, oxycodone and methadone. However, it doesn't activate these receptors as much as these other opioids, which means it has a slower onset and a "ceiling effect" - a point at which the effects of the drug stop increasing. This makes it less likely to cause overdose, and the lower activation of the receptors means it doesn't cause as much sedation or euphoria. Buprenorphine can cause a rapid withdrawal if taken by someone who's already dependent on opioids, so it's important that they
When to interrupt dosage
The measure of Zubsolv depends on the diagnosed affliction, including Pain, Pain and Opioid Dependence. The quantity of dosage likewise varies as indicated by the method of delivery (e.g. Tablet - Oral or Sublingual) specified in the table beneath.Condition
Dosage
Administration
Pain
16.0 mg, 0.0075 mg/hour, , 0.324 mg/mL, 0.45 mg, 0.6 mg, 0.3 mg/mL, 0.9 mg, 0.75 mg, 0.005 mg/hour, 0.01 mg/hour, 8.0 mg, 2.0 mg, 12.0 mg, 0.0025 mg/hour, 0.015 mg/hour, 11.4 mg, 4.0 mg, 1.4 mg, 5.7 mg, 8.6 mg, 0.7 mg, 2.9 mg, 24.0 mg, 0.02 mg/hour, 15.0 mg/hour, 300.0 mg/mL, 10.0 mg/hour, 7.5 mg/hour, 1000.0 mg/mL, 32.0 mg, 5.0 mg/hour, 20.0 mg/hour, 74.2 mg, 80.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 4.2 mg, 2.1 mg, 100.0 mg, 160.0 mg, 6.3 mg, 300.0 mg, 0.2 mg, 64.0 mg, 128.0 mg, 96.0 mg
Tablet - Oral, Sublingual, Tablet, Film, soluble - Buccal; Sublingual, , Patch, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Solution, gel forming, extended release - Subcutaneous, Subcutaneous, Tablet, orally disintegrating, Intramuscular; Intravenous, Transdermal, Tablet - Sublingual, Film, Implant - Subcutaneous, Patch, extended release, Injection, solution, Film, soluble - Buccal, Oral, Buccal, Film, soluble, Film, soluble - Sublingual, Patch - Transdermal, Patch, extended release - Transdermal, Injection - Intramuscular; Intravenous, Film - Buccal; Sublingual, Implant, Injection, Buccal; Sublingual, Solution, gel forming, extended release, Pill, Solution - Subcutaneous, Injection, solution - Intramuscular; Intravenous, Solution
Opioid Dependence
16.0 mg, 0.0075 mg/hour, , 0.324 mg/mL, 0.45 mg, 0.6 mg, 0.3 mg/mL, 0.9 mg, 0.75 mg, 0.005 mg/hour, 0.01 mg/hour, 8.0 mg, 2.0 mg, 12.0 mg, 0.0025 mg/hour, 0.015 mg/hour, 11.4 mg, 4.0 mg, 1.4 mg, 5.7 mg, 8.6 mg, 0.7 mg, 2.9 mg, 24.0 mg, 0.02 mg/hour, 15.0 mg/hour, 300.0 mg/mL, 10.0 mg/hour, 7.5 mg/hour, 1000.0 mg/mL, 32.0 mg, 5.0 mg/hour, 20.0 mg/hour, 74.2 mg, 80.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 4.2 mg, 2.1 mg, 100.0 mg, 160.0 mg, 6.3 mg, 300.0 mg, 0.2 mg, 64.0 mg, 128.0 mg, 96.0 mg
Tablet - Oral, Sublingual, Tablet, Film, soluble - Buccal; Sublingual, , Patch, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Solution, gel forming, extended release - Subcutaneous, Subcutaneous, Tablet, orally disintegrating, Intramuscular; Intravenous, Transdermal, Tablet - Sublingual, Film, Implant - Subcutaneous, Patch, extended release, Injection, solution, Film, soluble - Buccal, Oral, Buccal, Film, soluble, Film, soluble - Sublingual, Patch - Transdermal, Patch, extended release - Transdermal, Injection - Intramuscular; Intravenous, Film - Buccal; Sublingual, Implant, Injection, Buccal; Sublingual, Solution, gel forming, extended release, Pill, Solution - Subcutaneous, Injection, solution - Intramuscular; Intravenous, Solution
Pain
16.0 mg, 0.0075 mg/hour, , 0.324 mg/mL, 0.45 mg, 0.6 mg, 0.3 mg/mL, 0.9 mg, 0.75 mg, 0.005 mg/hour, 0.01 mg/hour, 8.0 mg, 2.0 mg, 12.0 mg, 0.0025 mg/hour, 0.015 mg/hour, 11.4 mg, 4.0 mg, 1.4 mg, 5.7 mg, 8.6 mg, 0.7 mg, 2.9 mg, 24.0 mg, 0.02 mg/hour, 15.0 mg/hour, 300.0 mg/mL, 10.0 mg/hour, 7.5 mg/hour, 1000.0 mg/mL, 32.0 mg, 5.0 mg/hour, 20.0 mg/hour, 74.2 mg, 80.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 4.2 mg, 2.1 mg, 100.0 mg, 160.0 mg, 6.3 mg, 300.0 mg, 0.2 mg, 64.0 mg, 128.0 mg, 96.0 mg
Tablet - Oral, Sublingual, Tablet, Film, soluble - Buccal; Sublingual, , Patch, Tablet, orally disintegrating - Sublingual, Film - Buccal, Pill - Sublingual, Solution, gel forming, extended release - Subcutaneous, Subcutaneous, Tablet, orally disintegrating, Intramuscular; Intravenous, Transdermal, Tablet - Sublingual, Film, Implant - Subcutaneous, Patch, extended release, Injection, solution, Film, soluble - Buccal, Oral, Buccal, Film, soluble, Film, soluble - Sublingual, Patch - Transdermal, Patch, extended release - Transdermal, Injection - Intramuscular; Intravenous, Film - Buccal; Sublingual, Implant, Injection, Buccal; Sublingual, Solution, gel forming, extended release, Pill, Solution - Subcutaneous, Injection, solution - Intramuscular; Intravenous, Solution
Warnings
Zubsolv has twenty-two contraindications and should not be ingested when enduring any of the ailments outlined in the subsequent table.Zubsolv ContraindicationsCondition
Risk Level
Notes
Gastrointestinal obstruction
Do Not Combine
opioid naive
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Oral Mucositis
Do Not Combine
Toxoplasma Infections
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Long QT Syndrome
Do Not Combine
Hypomagnesemia
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Hypokalemia
Do Not Combine
Hypocalcemia
Do Not Combine
Asthma
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
Asthma
Do Not Combine
Alcohol Withdrawal Delirium
Do Not Combine
Mental Depression
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Buprenorphine may interact with Toxoplasma Infections
Common Zubsolv Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Zubsolv Toxicity & Overdose RiskSigns of an acute overdose of morphine include small pupils, drowsiness, low blood pressure, and difficulty breathing. If left untreated, it can lead to death.
Zubsolv Novel Uses: Which Conditions Have a Clinical Trial Featuring Zubsolv?
Currently, 21 active studies are assessing the potential of Zubsolv for treating Opioid Dependence, Pain and Palliative Care.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Opioid Dependence
13 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Zubsolv Reviews: What are patients saying about Zubsolv?
5Patient Review
4/6/2017 Zubsolv has been a game-changer for me. I was on suboxone twice before and relapsed both times, but this third time feels different. Zubsolv doesn't make me feel as terrible as suboxone did, and I'm finally starting to see progress in my recovery.
5Patient Review
4/7/2017 I feel like this drug has helped me more than any other I've tried. Zubsolv is definitely the way to go if you're looking to get off drugs.
5Patient Review
7/30/2014 I switched from Sub to Zub on 7/1/14 when my insurance stopped covering the former. I find Zub WAY more effective: it tastes better, dissolves faster, and gets into my bloodstream quickly. I was on 16mg Sub and now 10mg of Zub and can tell NO difference. The only downside is that it's hard to open the package.
5Patient Review
5/1/2019 This medication has been integral in my sobriety. It curbs cravings and helps me feel more confident about my ability to stay clean. I highly recommend it to anyone who is addicted or trying to stay sober.
5Patient Review
12/11/2019 These pills have completely changed my life for the better. I highly recommend them to anyone struggling with addiction.
4.7Patient Review
7/31/2015 I've been on zubsolv for almost a year now and I much prefer it to sub. To me, it lasts longer and tastes better. Additionally, I get a bit of a rush from it unlike sub which made me incredibly tired. The only problem with zub is that my pharmacy isn't always well-stocked with it.
4Patient Review
7/31/2017 Suboxone is my preferred treatment, but Zubsolv works just as well. The only downside is that the tablets are not as easy to use as the strips.
1.7Patient Review
11/11/2022 Subutol was a terrible experience for me. It made my headaches and muscle pain in my legs worse, sapped all my energy, and made it hard to get out of bed or focus on anything. I got back on Suboxone and within two days felt one hundred percent better.
1.3Patient Review
8/3/2015 Suboxone was a huge disappointment. I experienced intense water retention, raw tongue and swelling, lethargy, lack of energy, withdrawal symptoms, no pain relief, vision problems, constipation, irritability, and difficulty opening the packaging.
1Patient Review
1/18/2015 I was recently switched to Zubsolv because my insurance stopped covering name brand Suboxone films and then the generic Suboxone tablets. I hate the minty taste and i've been depressed since switching last week. I have been having trouble sleeping and for the first time in years i'm experiencing withdrawls again.
Patient Q&A Section about zubsolv
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Zubsolv?
"You may experience the following symptoms: dizziness, drowsiness, blurred vision, feeling drunk, trouble concentrating, withdrawal symptoms, tongue pain, redness or numbness inside your mouth, nausea, vomiting, constipation, headache, back pain, fast or pounding heartbeats, increased sweating, or sleep problems (insomnia)."
Answered by AI
How does Zubsolv make you feel?
"However, people taking buprenorphine in studies have reported some emotional side effects, such as anxiety, depression, and nervousness. Additionally, people going through withdrawal may also experience these emotions. withdrawal from buprenorphine can cause anxiety."
Answered by AI
What is Zubsolv used for?
"Naloxone reverses the effects of opioids and can cause withdrawal symptoms in people who take opioids.
This drug is a combination of two medicines, buprenorphine and naloxone, and is used to treat dependence or addiction to opioids. Buprenorphine is a drug that belongs to a class of mixed opioid agonist-antagonists, meaning that it helps to prevent withdrawal symptoms caused by quitting other opioids. Naloxone, on the other hand, reverses the effects of opioids and can actually cause withdrawal symptoms in people who take opioids regularly."
Answered by AI
Does Zubsolv have Narcan in it?
"Zubsolv contains two active drugs: buprenorphine and naloxone. Zubsolv comes in six strengths, which contain different amounts (in milligrams) of the drugs. The lowest strength contains 0.7 mg of buprenorphine and 0.18 mg of naloxone."
Answered by AI