Cefepime Dosing for Infections
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method. The new dosing method uses only doses that are available in normal care, but choosing between the different doses is based on more information about the patient's body including their kidney function. The primary purpose of this study is to test how easy it is for healthcare professionals to use the new dosing method and how best to conduct the trial. The study will also assess if the new dosing method helps patients recover faster and reduces side effects.
Who Is on the Research Team?
Erin Barreto, PharmD, PhD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for very sick patients with severe bacterial skin infections or sepsis, which is a dangerous body response to infection. Participants must have certain conditions like acute bacterial skin and skin structure infections or septic shock. The study excludes specific details not provided.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Cefepime
Trial Overview
The BLOOM trial compares usual antibiotic dosing with a new individualized method based on patient information such as kidney function. It aims to see if healthcare professionals can easily use the new method and how it affects patient recovery and side effects.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Clinical decision support to encourage use of an individualized cefepime dosing algorithm based on eGFRcr-cysC and weight.
The standard of care group will receive empiric dosing of cefepime, using an institutional antimicrobial guide based on four categories of eGFRcr.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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