~26 spots leftby Mar 2026

Fisetin for Improved Vascular Function in Aging

SH
Overseen BySarah Haydu, MA
Age: 65+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 1 & 2
Recruiting
Sponsor: University of Colorado, Boulder
Must not be taking: Senolytics, Cardiovascular-acting, others
Disqualifiers: Active malignancy, Unstable CVD, others

Trial Summary

What is the purpose of this trial?

This trial tests if fisetin, a natural substance from fruits and vegetables, can improve blood vessel health and reduce artery stiffness in older adults. It works by making old cells act younger, reducing cell stress, and lowering inflammation. The study will also check if fisetin is safe and well-tolerated. Fisetin is a natural flavonoid found in various fruits and vegetables, known for its antioxidant, anti-inflammatory, and anti-carcinogenic properties.

Will I have to stop taking my current medications?

The trial does not specify if you must stop taking your current medications, but you cannot participate if you have started new cardiovascular medications within 3 months or certain dietary supplements within 1 month before the trial. If you are taking fisetin or similar compounds, you must stop 6 months before joining.

What data supports the effectiveness of the drug Fisetin for improving vascular function in aging?

Research shows that Fisetin can improve arterial function in old mice by reducing cell aging and inflammation, which helps increase the availability of nitric oxide (a molecule that helps blood vessels relax). This suggests Fisetin might help improve blood vessel health as we age.12345

Is fisetin safe for human use?

Fisetin, a natural compound found in fruits and vegetables, has been studied in animals and shows potential benefits for vascular health, but specific safety data in humans is limited. Animal studies suggest it may help improve blood circulation and reduce age-related arterial issues, but more research is needed to confirm its safety in humans.16789

How does the drug fisetin differ from other treatments for improving vascular function in aging?

Fisetin is unique because it acts as a senolytic, meaning it helps remove old, dysfunctional cells that contribute to aging-related issues in blood vessels. This process reduces inflammation and oxidative stress, improving the function of the cells lining the blood vessels and decreasing arterial stiffness, which is not a common mechanism in other treatments for vascular aging.1251011

Research Team

MJ

Matthew J Rossman, PhD

Principal Investigator

University of Colorado, Boulder

Eligibility Criteria

This trial is for people aged 65 or older, specifically postmenopausal women and men with a BMI under 40. Participants should not have had significant weight changes recently, must be free of serious chronic diseases like unstable heart conditions, and agree to not donate blood during the study.

Inclusion Criteria

I haven't donated blood in the last 8 weeks and won't donate during or for 8 weeks after the study.
I understand and can follow the study's procedures.
I don't have any serious, long-term health problems that are not under control.
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Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive intermittent treatment with fisetin or placebo, with two, three-day dosing periods separated by two weeks

4 weeks
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Fisetin (Flavonoid)
Trial OverviewThe trial is testing fisetin, a flavonoid compound thought to improve blood vessel function and reduce stiffness in arteries among older adults. It will compare fisetin's effects against a placebo while exploring how it might work by affecting oxidative stress and other aging-related factors.
Participant Groups
2Treatment groups
Active Control
Placebo Group
Group I: FisetinActive Control1 Intervention
Fisetin will be administered in an intermittent manner with two, three-day dosing periods at a dose of 2 mg/kg/day separated by two weeks.
Group II: PlaceboPlacebo Group1 Intervention
Placebo capsules identical in appearance to fistin capsules will be administered in an intermittent manner with two, three-day dosing periods separated by two weeks.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Boulder

Lead Sponsor

Trials
128
Recruited
29,600+

American Heart Association

Collaborator

Trials
352
Recruited
6,196,000+

Findings from Research

Fisetin, a natural compound, effectively reduces cellular senescence and inflammation in old mice, leading to improved arterial function and increased nitric oxide bioavailability.
The study demonstrated that fisetin lowers arterial stiffness and promotes favorable arterial wall remodeling, suggesting its potential as a therapy for age-related arterial dysfunction.
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.Mahoney, SA., Venkatasubramanian, R., Darrah, MA., et al.[2023]
Oral supplementation with apigenin significantly improved arterial function in aging mice by restoring endothelial-dependent dilation and increasing nitric oxide bioavailability, demonstrating its potential as a therapeutic for arterial aging.
Apigenin also mitigated age-related aortic stiffness and prevented foam cell formation, indicating its role in reversing key indicators of arterial dysfunction and reducing cardiovascular disease risk.
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging.Clayton, ZS., Hutton, DA., Brunt, VE., et al.[2022]
Total flavonoids of Flos Chrysanthemi (TFFC) were found to protect endothelial cells from oxidative stress, significantly improving vasorelaxation in rat mesenteric arteries that were impaired by superoxide anions.
TFFC not only induced vasodilation but also countered the negative effects of oxidative stress on calcium influx and membrane potential in endothelial cells, suggesting its potential as a therapeutic agent for cardiovascular diseases linked to oxidative damage.
Total flavonoids of Flos Chrysanthemi protect arterial endothelial cells against oxidative stress.He, D., Ru, X., Wen, L., et al.[2014]

References

Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. [2023]
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. [2022]
Total flavonoids of Flos Chrysanthemi protect arterial endothelial cells against oxidative stress. [2014]
Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease. [2020]
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. [2021]
Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility. [2020]
The Role of Potassium Channels in the Vasodilatation Induced by Resveratrol and Naringenin in Isolated Human Umbilical Vein. [2019]
Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites. [2022]
Heartwood extract of Rhus verniciflua Stokes and its active constituent fisetin attenuate vasoconstriction through calcium-dependent mechanism in rat aorta. [2021]
10.Czech Republicpubmed.ncbi.nlm.nih.gov
Age-related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products. [2016]
Aging and vascular responses to flavanol-rich cocoa. [2013]