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What is Zocor
SimvastatinThe Generic name of this drug
Treatment SummarySimvastatin, also known as the brand name product Zocor, is a medication used to lower cholesterol levels and reduce the risk of cardiovascular disease. It belongs to a class of drugs called statins, which work by blocking the production of cholesterol in the liver. Simvastatin and other statin drugs are prescribed to people with a moderate to high risk of developing cardiovascular disease, such as those with type 2 diabetes. These drugs have been shown to significantly lower bad cholesterol (LDL) levels and reduce the risk of cardiovascular disease and death. Rosuvastatin is the most potent statin drug, and simvast
Zocoris the brand name
Zocor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zocor
Simvastatin
1991
620
Approved as Treatment by the FDA
Simvastatin, otherwise called Zocor, is approved by the FDA for 13 uses like Diabetes and Coronary heart disease .Diabetes
Coronary heart disease
Hypercholesterolemia
Used to treat Heterozygous Familial Hypercholesterolemia (HeFH) in combination with Ezetimibe
Peripheral Vascular Disease
Lipid-Lowering Therapy
Used to treat Lipid-Lowering Therapy in combination with Ezetimibe
Homozygous Familial Hypercholesterolemia
Used to treat Homozygous Familial Hypercholesterolaemia (HoFH) in combination with Ezetimibe
cholesterol
Helps manage High Cholesterol
Cerebrovascular Disorders
prophylaxis of cardiovascular event
Diet
Used to treat Diet in combination with Ezetimibe
Physical Activity
Used to treat Exercise in combination with Ezetimibe
Mixed Hyperlipidemia
Used to treat Mixed Hyperlipidemia in combination with Ezetimibe
Cardiovascular Events
Effectiveness
How Zocor Affects PatientsSimvastatin is a medication used to lower cholesterol levels, specifically LDL (low density lipoprotein) cholesterol. Research has shown that high LDL levels are associated with an increased risk of developing cardiovascular disease. Taking simvastatin can reduce the risk of cardiovascular morbidity and mortality, even for those with a low risk of having a major vascular event within 5 years. Short-term side effects of simvastatin may include muscle pain, tenderness or weakness, and increases in HbA1c and fasting serum glucose levels. Long-term use of this medication may cause liver enzyme abnormalities and may interact with certain other drugs
How Zocor works in the bodySimvastatin is a drug that works to reduce cholesterol levels in your body. It does this by competing with another molecule called HMG-CoA for a particular enzyme found in the liver. When simvastatin binds to this enzyme, it prevents HMG-CoA from being converted into cholesterol, leading to lower cholesterol levels. Simvastatin also has additional effects outside of cholesterol reduction, such as preventing the buildup of potentially toxic sterols and promoting better blood vessel health. It also binds to a molecule called LFA-1 which helps to regulate the body's immune response.
When to interrupt dosage
The suggested amount of Zocor is contingent on the diagnosed condition, including Hypercholesterolemia, Diet and Type 2 Diabetes. The dosage is contingent on the delivery technique portrayed in the accompanying table.Condition
Dosage
Administration
Homozygous Familial Hypercholesterolemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Coronary heart disease
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
prophylaxis of cardiovascular event
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Diabetes
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Cardiovascular Events
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Lipid-Lowering Therapy
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Physical Activity
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Type 2 Diabetes
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
cholesterol
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Mixed Hyperlipidemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Diet
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Hypercholesterolemia
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Peripheral Vascular Disease
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Cerebrovascular Disorders
, 80.0 mg, 10.0 mg, 20.0 mg, 40.0 mg, 5.0 mg, 20.0 mg/mL, 40.0 mg/mL, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Tablet, coated, Tablet, coated - Oral, Periarticular, Tablet, film coated - Periarticular
Warnings
Zocor ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
active liver disease
Do Not Combine
Common Zocor Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Simvastatin.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Simvastatin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Simvastatin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Simvastatin.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Simvastatin.
Zocor Novel Uses: Which Conditions Have a Clinical Trial Featuring Zocor?
Presently, 756 active trials are examining the potential of Zocor to alleviate Cerebrovascular Disorders, Type 2 Diabetes and Physical Activity.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
cholesterol
6 Actively Recruiting
Phase 3, Not Applicable
Hypercholesterolemia
2 Actively Recruiting
Phase 3, Not Applicable
Mixed Hyperlipidemia
0 Actively Recruiting
Cerebrovascular Disorders
0 Actively Recruiting
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable
Coronary heart disease
0 Actively Recruiting
Lipid-Lowering Therapy
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Diabetes
540 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Peripheral Vascular Disease
8 Actively Recruiting
Phase 1, Not Applicable, Phase 3
Zocor Reviews: What are patients saying about Zocor?
5Patient Review
2/5/2015 In just six months, this medication lowered my numbers by 100 points. Now they're at a healthy level!
4.3Patient Review
4/19/2014 Unfortunately, I developed liver failure as a result of this treatment.
3.7Patient Review
3/17/20143.3Patient Review
7/11/2016 After years of taking this drug, I started experiencing muscle aches. Prior to that, I had unexplained peripheral neuropathy which several neurological tests and MRI/MRAs couldn't explain. Once I stopped taking the medication, though, those feelings went away.
3.3Patient Review
1/26/2017 This treatment alleviated my pain somewhat, but it didn't completely get rid of it. I experienced the most relief in my back and legs.
3Patient Review
9/4/2014 I'm on the fence about whether or not to continue this treatment. My doctor says it's indefinite, but if I make some lifestyle changes I may not need it. Additionally, there are a lot of side effects that concern me like weight loss, memory problems, and depletion of CO Q 10.
2.3Patient Review
6/12/2017 I stopped taking this after three weeks because I started experiencing intense pain in my legs. Based on other reviews, it seems like I'm not the only one who had this reaction.
2.3Patient Review
10/7/2014 I experienced some muscle pain and fatigue as side effects of this medication.
1.7Patient Review
6/24/2014 I noticed significant hair loss, terrible headaches, and muscle pain within two weeks of starting this medication. I'm going back to red yeast rice and COQ10. The former is a statin, but I think it's safer—at least with it I didn't have any adverse effects on my hair.
1.7Patient Review
10/15/2014 I've been taking this medication for three years now and my cholesterol levels have not budged.
1Patient Review
8/15/2017 I have lipo protine "a". Dr's want my good cholesterols very high. They put me on Zocor after several months on it I landed in the hospital with liver enzymesoff the charts. They got the good cholesterol number they wanted took over 3 years to get liver enzymes back in check.
Patient Q&A Section about zocor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are side effects of Zocor?
"and vomiting
The text lists a number of digestive problems, including heartburn, gas, bloating, stomach pain, indigestion, nausea, constipation, diarrhea, and vomiting."
Answered by AI
Is Zocor the same as Lipitor?
"The drugs studied have shown to have positive effects on levels of "good cholesterol" (HDL or high-density lipoprotein). One study in particular showed that while both Lipitor and Zocor are effective in lowering LDL levels, Zocor is slightly more effective in increasing HDL and has fewer side effects when it comes to gastrointestinal issues."
Answered by AI
What is the drug Zocor used for?
"Simvastatin is a drug that helps lower bad cholesterol and fats and raise good cholesterol in the blood. It belongs to a group of drugs known as statins and works by reducing the amount of cholesterol made by the liver."
Answered by AI
Is Zocor or Crestor better?
"Crestor is a newer and more potent drug for lowering cholesterol than Zocor. Both drugs may cause similar side effects including headache, nausea, vomiting, diarrhea, and muscle pain. However, rare side effects for both drugs may also include damage to the liver, muscle, and kidney."
Answered by AI