8 Participants Needed

Beetroot Juice for Microvascular Angina

(NO-ANOCA Trial)

SW
Overseen ByShuo Wang
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Do I have to stop taking my current medications for the trial?

The trial requires that you stop taking certain medications, specifically nitroglycerine, PDE-5 inhibitors (like Cialis or Viagra), and xanthine oxidase inhibitors (like Allopurinol).

What data supports the effectiveness of the treatment Nitrate Rich Beetroot Juice for Microvascular Angina?

Research shows that beetroot juice, which is rich in nitrates, can improve exercise performance and lower blood pressure in various groups, including those with chronic conditions like COPD and type 2 diabetes. This suggests it might also help with microvascular angina by improving blood flow and reducing heart strain.12345

Is beetroot juice safe for human consumption?

Beetroot juice, which is rich in nitrates, has been shown to be generally safe for human consumption. Studies have reported that it can lower blood pressure and improve exercise performance without significant adverse effects.13678

How does beetroot juice treatment for microvascular angina differ from other treatments?

Beetroot juice is unique for microvascular angina because it is rich in nitrates, which are converted in the body to nitric oxide, a molecule that helps improve blood flow and reduce blood pressure. This natural approach differs from standard medications by using dietary supplementation to enhance cardiovascular function.135910

What is the purpose of this trial?

The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD. The main questions it aims to answer are:AIM 1: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase cardiac perfusion and improve quality of life compared to placebo.AIM 2: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase physical fitness and reduce angina and dyspnea symptoms compared to placebo.Exploratory AIM 3: Test the hypothesis that fourteen days of nitrate rich beetroot juice will improve vascular health and function.Participants will:* Take study beverage for 4 weeks total.* Stress Cardiac magnetic resonance imaging and 12 lead electrocardiograms* Complete questionnaires* Cycling exercise test* Non invasive vascular testing* Blood draws

Research Team

PR

Patricia Rodriguez-Lozano, MD

Principal Investigator

University of Virginia

Eligibility Criteria

This trial is for women with ANOCA and CMD, conditions affecting heart blood flow and muscle function. Participants will undergo various tests including cardiac imaging, ECGs, exercise testing, vascular assessments, and blood draws over a 4-week period.

Inclusion Criteria

Willing and able to provide written informed consent
I am female.
I was referred for a heart check-up due to suspected blockage within the last 2 years.
See 3 more

Exclusion Criteria

History of reaction to iodinated contrast agents
Pregnancy or women who are breast-feeding
Greater than first degree heart block
See 23 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive either nitrate-rich beetroot juice or placebo for 14 days, followed by a 7-day washout, then the alternate treatment for another 14 days

5 weeks
Baseline and end of each treatment period visits

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Nitrate Rich Beetroot Juice
  • Placebo (Nitrate depleted beetroot juice)
Trial Overview The study is examining if drinking nitrate-rich beetroot juice can improve heart blood flow, physical fitness, quality of life, reduce chest pain (angina), shortness of breath (dyspnea), and enhance vascular health compared to a placebo beetroot juice.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Placebo followed by Beetroot juiceExperimental Treatment1 Intervention
Placebo (70 mL nitrate depleted beetroot juice) for 14 days followed by Nitrate rich Beetroot juice for 14 days
Group II: Beetroot juice followed by placeboExperimental Treatment1 Intervention
70mL Nitrate Rich Beetroot Juice for 14 days followed by placebo (70mL nitrate depleted beetroot juice) for 14 days

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Virginia

Lead Sponsor

Trials
802
Recruited
1,342,000+

Findings from Research

In a study involving 15 COPD patients, acute ingestion of beetroot juice significantly improved exercise capacity, allowing patients to exercise longer at a submaximal workload compared to a placebo.
Beetroot juice also led to notable reductions in both resting and exercise-induced blood pressure, indicating potential cardiovascular benefits alongside improved exercise performance.
Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients.Berry, MJ., Justus, NW., Hauser, JI., et al.[2018]
In a study involving 12 healthy young African-American females, beetroot juice significantly increased plasma nitric oxide (NO) levels, which is linked to improved cardiovascular function during exercise.
The consumption of beetroot juice led to decreased oxygen consumption, systolic blood pressure, and heart rate during exercise, suggesting it may reduce cardiac workload and improve efficiency in healthy individuals.
Cardiorespiratory function associated with dietary nitrate supplementation.Bond, V., Curry, BH., Adams, RG., et al.[2021]
Ingesting beetroot juice rich in nitrate (NO3-) significantly increases plasma levels of both nitrate and nitrite (NO2-), which can positively affect cardiovascular measures like mean arterial pressure (MAP).
While both NO3- and NO2- have the potential to lower MAP, the expected reduction in systolic and diastolic blood pressure was not observed, suggesting that the role of NO2- in blood pressure regulation alongside NO3- needs further investigation.
Pharmacokinetics of Nitrate and Nitrite Following Beetroot Juice Drink Consumption.Jakubcik, EM., Rutherfurd-Markwick, K., Chabert, M., et al.[2021]

References

Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. [2018]
Cardiorespiratory function associated with dietary nitrate supplementation. [2021]
Pharmacokinetics of Nitrate and Nitrite Following Beetroot Juice Drink Consumption. [2021]
Dietary Inorganic Nitrate/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in Patients With Type 2 Diabetes Mellitus. [2023]
Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial. [2023]
What's in Your Beet Juice? Nitrate and Nitrite Content of Beet Juice Products Marketed to Athletes. [2021]
Efficacy and Variability in Plasma Nitrite Levels during Long-Term Supplementation with Nitrate Containing Beetroot Juice. [2023]
The effect of nitrate supplementation on muscle contraction in healthy adults. [2015]
Dietary nitrate load lowers blood pressure and renal resistive index in patients with chronic kidney disease: A pilot study. [2018]
10.United Statespubmed.ncbi.nlm.nih.gov
Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. [2022]
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