Beetroot Juice for Microvascular Angina
(NO-ANOCA Trial)
Trial Summary
Do I have to stop taking my current medications for the trial?
The trial requires that you stop taking certain medications, specifically nitroglycerine, PDE-5 inhibitors (like Cialis or Viagra), and xanthine oxidase inhibitors (like Allopurinol).
What data supports the effectiveness of the treatment Nitrate Rich Beetroot Juice for Microvascular Angina?
Research shows that beetroot juice, which is rich in nitrates, can improve exercise performance and lower blood pressure in various groups, including those with chronic conditions like COPD and type 2 diabetes. This suggests it might also help with microvascular angina by improving blood flow and reducing heart strain.12345
Is beetroot juice safe for human consumption?
How does beetroot juice treatment for microvascular angina differ from other treatments?
Beetroot juice is unique for microvascular angina because it is rich in nitrates, which are converted in the body to nitric oxide, a molecule that helps improve blood flow and reduce blood pressure. This natural approach differs from standard medications by using dietary supplementation to enhance cardiovascular function.135910
What is the purpose of this trial?
The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD. The main questions it aims to answer are:AIM 1: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase cardiac perfusion and improve quality of life compared to placebo.AIM 2: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase physical fitness and reduce angina and dyspnea symptoms compared to placebo.Exploratory AIM 3: Test the hypothesis that fourteen days of nitrate rich beetroot juice will improve vascular health and function.Participants will:* Take study beverage for 4 weeks total.* Stress Cardiac magnetic resonance imaging and 12 lead electrocardiograms* Complete questionnaires* Cycling exercise test* Non invasive vascular testing* Blood draws
Research Team
Patricia Rodriguez-Lozano, MD
Principal Investigator
University of Virginia
Eligibility Criteria
This trial is for women with ANOCA and CMD, conditions affecting heart blood flow and muscle function. Participants will undergo various tests including cardiac imaging, ECGs, exercise testing, vascular assessments, and blood draws over a 4-week period.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either nitrate-rich beetroot juice or placebo for 14 days, followed by a 7-day washout, then the alternate treatment for another 14 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Nitrate Rich Beetroot Juice
- Placebo (Nitrate depleted beetroot juice)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Virginia
Lead Sponsor